Reference

The effect of sulfhydryl block on the binding of H1-antagonists to the muscarinic receptor

The effect of sulfhydryl block on the binding of H1-antagonists to the muscarinic receptor. Burgen, A. S. V.; Harbird, C. J. (Dep. 91-84-9 and 41149-66-0 are cas registry numbers. These chemicals are also mentioned in this article. Pharmacol., Univ. Cambridge, Cambridge, UK). Br. J. Pharmacol., 80(4), 600-1 (English) 1983. CODEN: BJPCBM. ISSN: 0007-1188. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The treatment of brain muscarinic receptors with the sulfhydryl blocker p-chlormercuribenzoate (I) [138-85-2] reduced the binding affinity of the 6 H1-antagonists tested; the redn. ranged from a factor of 2.4 for mepyramine [91-84-9] to 15.8 for diphenhydramine [58-73-1]. However, there appeared to be no significant correlation between the affinity of these drugs for the muscarinic receptor and the change produced by I nor any correlation with the reported affinity for the H1 receptor. .

The effect of antihistaminics on cataleptogenic action of analgesics and haloperidol

The effect of antihistaminics on cataleptogenic action of analgesics and haloperidol. Malec, Danuta; Langwinski, Romuald (Inst. Clin. Pathol., Med. Acad., Lublin 20-081, Pol.). Pol. J. Pharmacol. Pharm., 35(4), 293-300 (English) 1983. CODEN: PJPPAA. ISSN: 0301-0244. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect of benzhydramine [58-73-1], thenalidine tartrate [2784-55-6], mepyramine maleate [59-33-6] (H1 receptor antagonists) and cimetidine [51481-61-9] (H2 receptor antagonist) on the cataleptogenic action of morphine [57-27-2], codeine [76-57-3], fentanyl [437-38-7], and haloperidol [52-86-8] was studied in rats. Benzhydramine antagonized the catalepsy induced by the analgesics (particularly by codeine). The antagonistic effect of thenalidine was weaker (but also very prominent on codeine catalepsy).There are some commonly used reagents with their cas registry numbers 76-57-3 and 437-38-7 in this article. Mepyramine did not affect the catalepsy induced by the analgesics. All 3 H1 receptor antagonists attenuated the catalepsy induced by haloperidol. Cimetidine (intraventricularly) did not affect the catalepsy induced either by the analgesics or by haloperidol. Apparently, the antagonistic action of benzhydramine and thenalidine against analgesic catalepsy is related to their antiserotonin properties; the anticataleptic activity of all 3 H1 receptor antagonists against haloperidol catalepsy is caused by their anticholinergic and antiserotonin properties. .