Reference

Toxicology and carcinogenesis studies of methyl carbamate (CAS No

Toxicology and carcinogenesis studies of methyl carbamate (CAS No. 598-55-0) in F344/N rats and B6C3F1 mice. (Gavage studies). (National Toxicology Program, Research Triangle Park, NC 27709, USA). Natl. Toxicol. Program Tech. Rep. Ser., 328, 176 pp. (English) 1987. CODEN: NTPSE3. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) Toxicol. and carcinogenesis studies of Me carbamate (98% pure) were conducted by exposing groups of rats and mice by gavage in water in a single dose and by repeated administration for 16 days, 13 wk, 6 mo, 12 mo, 18 mo, and 2 yr. In addn., short-term mutagenicity studies in bacteria, mammalian cells, and Drosophila and of unscheduled DNA synthesis in rat liver cells were conducted. In the single-administration studies, 5/5 male and 5/5 female rats that received 8000 mg/kg Me carbamate and 2/5 males and 5/5 females that received 4000 mg/kg died before the end of the 15-day observation period. Five of 5 male and 5/5 female mice that received 8000 mg/kg and 1/5 males and 1/5 females that received 4000 mg/kg died before the end of the 15-day observation period. No compd.-related morphol. effects were obsd. in rats or mice that received 2000 mg/kg. In the 16-day studies, all rats dosed at 2000 or 4000 mg/kg died, and 3/5 male rats that received 1000 mg/kg died. Male mice that received 2000 or 4000 mg/kg, female mice that received 4000 mg/kg, and 1/5 female mice that received 2000 mg/kg died. No compd.-related gross pathol. or histopathol. effects were seen in male or female rats (groups of 5 each) that received 500 mg/kg or in mice that received 1000 mg/kg. In the 13-wk studies, groups of 10 male and 10 female rats and mice received up to 800 mg/kg (male rats), 1000 mg/kg (female rats), 1500 mg/kg (male mice), or 2000 mg/kg (female mice). Four of 10 male rats that received 800 mg/kg and 1/10 female rats that received 1000 mg/kg died of compd.-related causes before the end of the studies. Toxic hepatitis, splenic pigmentation, bone marrow atrophy, and testicular atrophy were obsd. in the 2 highest dose groups of rats. One of the female mice that received 2000 mg/kg died. The dosed female mice had significantly greater relative liver wts. than did the vehicle controls. Me carbamate was not mutagenic in Salmonella typhimurium strains TA97, TA98, TA100, or TA1535 when tested with or without metabolic activation in a preincubation protocol at doses up to 10 mg/plate. Me carbamate did not induce forward mutations in the mouse L5178Y/TK+/- lymphoma assay with or without metabolic activation at doses up to 5 mg/mL. Unscheduled DNA synthesis was not detected in rat hepatocytes after in vitro treatment with Me carbamate at concns. of 1.0-1000 mg/mL. When tested in Drosophila at doses of 25,000-50,000 ppm, Me carbamate did not induce sex-linked recessive lethal mutations. Results of tests for induction of chromosomal aberrations and sister chromatid exchanges by Me carbamate in cultured Chinese hamster ovary cells were also neg. at doses up to 5 mg/mL. Under the conditions of 6-, 12-, and 18-mo and 2-yr gavage studies, there was clear evidence of carcinogenic activity for male and female rats given Me carbamate as indicated by increased incidences of hepatocellular neoplastic nodules and hepatocellular carcinomas. There was no evidence of carcinogenic activity for male and female mice given Me carbamate at doses of 500 or 1000 mg/kg. Me carbamate also induced inflammation of the Harderian gland in male and female rats and adenomatous hyperplasia and histiocytosis of the lung in male and female mice.

Durable-press low formaldehyde release cellulosic textiles

Durable-press low formaldehyde release cellulosic textiles. Andrews, Bethlehem K.; Reinhardt, Robert M. (United States Dept. of Agriculture, USA). U. S. Pat. Appl. US 638827 A0 4 Jan 1985, 45 pp. Avail.Chemical with cas number 50-00-0 also plays role. NTIS Order No. PAT-APPL-6-638 827 (English). (United States of America). CODEN: XAXXAV. APPLICATION: US 84-638827 8 Aug 1984. DOCUMENT TYPE: Patent CA Section: 40 (Textiles) Etherified hydroxymethylated carbamates, prepd. by treating hydroxymethylated org. carbamates with water-sol. alcs., produce low-HCHO-release durable-press finishes on cellulosic textiles. Thus, 331.6 g 36.2% formalin [50-00-0] was added to a soln. of 174.2 g Me carbamate [598-55-0] in 40.0 g water, and the pH of the soln. was adjusted to 9 with dil. NaOH. The soln. was heated for 30 min at 60° to give a reaction mixt. contg. Me bis(hydroxymethyl)carbamate [4913-31-9]. The pH of 54.4 g reaction mixt. was adjusted to 2 with HCl and ethylene glycol [107-21-1] added before heating for 45 min at 70°. Adjustment of the pH to 6 gave a mixt. contg.Several substances like 50-00-0 may be metioned in this study. Me bis(hydroxyethoxymethyl)carbamate [92506-11-1]. Then 15 g above reaction mixt. was dild. with 53.4 g water to give a 9% solids concn. Addn. of 2.7% acidified MgCl2.6H2O and 0.1% Triton X-100 wetting agent produced a padding soln. that was applied to cotton print cloth at a pickup of 90-95%. The fabric was dried at original dimensions for 7 min at 60° and cured for 3 min at 160°. The finished fabric displayed wrinkle recovery angle 236° and HCHO release 80 and 19 mg/g before and after washing, resp. ..