CAS No.600-21-5,N-Methyl-DL-alanine Suppliers

Detail of "600-21-5"

CAS Number:

600-21-5

Name:

N-Methyl-DL-alanine

Molecular Structure:

Formula:

C₄H₉NO₂

Molecular Weight:

103.12

Synonyms:

Methylalanine, dl-;N-Methylalanine;

Density:

1.048 g/cm³

Melting Point:

317 °C

Boiling Point:

190.1 °C at 760 mmHg

Flash Point:

68.8 °C

Appearance:

white crystalline powder

Reference

Red-cell amino acid transport: Red-cell amino acid transport. Evidence for the presence of system ASC in mature human red blood cells. Young, James D.; Wolowyk, Michael W.; Jones, Sian M.; Ellory, J. Clive (Fac. Med., Chin. Univ. Hong Kong, Shatin, Hong Kong). Biochem. J., 216(2), 349-57 (English) 1983. CODEN: BIJOAK. ISSN: 0306-3275. DOCUMENT TYPE: Journal CA Section: 13 (Mammalian Biochemistry) The properties of Na+-dependent L-alanine transport in human erythrocytes were investigated using K+ as the Na+ substitute. Initial rates of Na+-dependent L-alanine uptake (0.2 mM extracellular amino acid) for erythrocytes from donors ranged 40-180 mmol/L cells/h at 37°.Several reagents with their cas registry numbers 6600-40-4 and 600-21-5 are used here. Amino acid uptake over the concn. range 0.1-8 mM was consistent with a single saturable component of Na+-dependent L-alanine transport. Apparent Km and Vmax values at 37° and 5° measured in erythrocytes from the same donor were 0.27 and 0.085 mM, resp., and 270 and 8.5 mmol/L cells/h, resp. The transporter responsible for this uptake was identified as system ASC on the basis of cross-inhibition studies with a series of 42 amino acids and amino acid analogs. Apparent Ki values for glycine, L-a-amino-n-butyrate, L-serine, and L-leucine as inhibitors of Na+-dependent L-alanine uptake at 37° were 4.2, 0.12, 0.16, and 0.70 mM, resp. Reticulocytes from a patient with inherited pyruvate kinase deficiency had a 10-fold elevated activity of Na+-dependent L-alanine uptake compared with erythrocytes from normal donors. Sepn. of erythrocytes according to cell d. (cell age) established that even the oldest mature erythrocytes retained significant Na+-dependent L-alanine transport activity. Amino acid transport was, however, a more sensitive indicator of cell age than was acetylcholinesterase activity. Erythrocytes accumulated L-alanine against its concn. gradient (distribution ratio ~1.5 after 4-h incubation), an effect that was abolished in Na+-free media. Na+-dependent L-alanine uptake was assocd. with L-alanine-dependent Na+ influx, the measured coupling ratio being 1:1. .

Detail of "600-21-5"

N-Methyl-DL-alanine

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CAS No.600-21-5 N-Methyl-DL-alanine

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CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

CAS No.600-21-5 N-Methyl-DL-alanine

Reference