Reference

Analgesic and antiinflammatory agents

Analgesic and antiinflammatory agents. Tsukada, Wataru; Nomura, Mamoru; Shiotani, Tadashi (Daiichi Seiyaku Co., Ltd., Japan). Japan. Kokai JP 51062839 5 Jun 1978 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A61K031-505. APPLICATION: JP 76-135517 11 Nov 1976. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Antiinflammatory and analgesic compns. contain the nonsteroid compds. ketoprofen [22071-15-4], naproxen [22204-53-1], tiaramide [32527-55-2], benzidamine [642-72-8], aspirin [50-78-2] or indomethacin [53-86-1] and mepirizole [18694-40-1] as active ingredients. The prepns. show synergistic effects and are almost free of side effects. The compns. can be made into capsules, tablets, injections, etc. E.g., antiinflammatory ID50 value (dose for 50% inhibition of inflammation) was 64.4 mg/kg for mepirizole alone, but was only 19.7 mg/kg for mepirizole in the presence of naproxen when tested in carrageenan-induced inflammation in rats.

Dose-dependent inhibition of sensory nerve activity in the feline dental pulp by anti-inflammatory drugs

Dose-dependent inhibition of sensory nerve activity in the feline dental pulp by anti-inflammatory drugs. Ahlberg, Karin Forssell (Dep. Pharmacol., Karolinska Inst., Stockholm, Swed.). Acta Physiol. Scand., 102(4), 434-40 (English) 1978. CODEN: APSCAX. ISSN: 0001-6772. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 14 Whether substances known to antagonize algogenic agents can block an exptl. induced increased sensory nerve activity in the dental pulp of the cat was studied. Increased neural activity following repeated brief heat stimulation was shown to be characteristic of the individual cat and could be utilized for intraindividual comparative studies on such increased activity. When indomethacin (I) [53-86-1], diclofenac sodium [15307-79-6], or naproxen [22204-53-1] were given i.v. as a pretreatment prior to stimulation, a consistent blocking effect on expected impulse activity as compared to the impulse activity in the control teeth was produced. I produced a dose-dependent inhibition (ID50 0.04-0.2 mg/kg). Diclofenac sodium (5 mg/kg) inhibited nerve activity by 51-91% and naproxen (15 mg/kg) by 92-95%. Methysergide [361-37-5] (0.02-0.08 mg/kg) did not show such a blocking effect. When the drugs were administered during a state of established increased neural activity there was no effect on the current impulse activity. Thus prostaglandins may be involved in certain stages of heat induced pulp inflammation and act as mediators of increased intradental sensory nerve excitability.