CAS No.672-15-1,L-Homoserine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	672-15-1
Name:	L-Homoserine
Article Data:	45

Formula:	C₄H₉NO₃
Molecular Weight:	119.12
Synonyms:	Butyric acid, 2-amino-4-hydroxy-, L- (8CI);Butanoic acid, 2-amino-4-hydroxy-, (S)-;2-amino-4-hydroxy-butanoic acid;2-Amino-4-hydroxybutyric acid;Butyric acid, 2-amino-4-hydroxy-, L-;(2S)-2-amino-4-hydroxy-butanoic acid;Homoserine (VAN);H-Homoserine;H-Hse-OH;L-Homo-serine;H-HoSer-OH;
EINECS:	211-590-6
Density:	1.3126 (rough estimate)
Melting Point:	203 °C
Boiling Point:	368.7 °C at 760 mmHg
Flash Point:	176.8 °C
Solubility:	1100 g/L (30 °C) in water
Appearance:	white to light yellow crystalline powder
Risk Codes:	36/37/38
Safety:	24/25
PSA:	83.55000
LogP:	-0.51900

Synthetic route

: 159487-41-9
Isopropyl (2S)-N-(trifluoroacetyl)homoserine

: 672-15-1
L-homoserine

Conditions

Conditions	Yield
With ethanol	95%
With potassium hydroxide In ethanol for 2h;	95%

: 3493-11-6
(3S)-(3-amino-3-carboxypropyl)dimethylsulfonium iodide

: 672-15-1
L-homoserine

Conditions

Conditions	Yield
With water; sodium hydrogencarbonate pH=2 - 5; Reflux;	92%
With sodium hydrogencarbonate In water pH=3 - 6; Inert atmosphere; Schlenk technique; Reflux;	92%
With sodium hydrogencarbonate In water at 140℃; for 0.5h;	69%

: 2185-03-7
L-homoserine lactone hydrochloride

: 672-15-1
L-homoserine

Conditions

Conditions	Yield
With triethylamine In water for 2h; Ambient temperature;	82%

: 29625-73-8
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-N-(4-L-aspartoyl)-2-deoxy-β-D-glucopyranosylamine

A: 672-15-1
L-homoserine

B: 102039-77-0
N,N'-diacetylchitobiosamine

C: 118943-00-3
1-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-amino-1,2-dideoxy-D-glucitol

D: 119009-35-7
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-amino-1,2-dideoxy-D-glucitol

Conditions

Conditions	Yield
With lithium hydroxide; lithium borohydride; trilithium citrate In water; tert-butyl alcohol at 45℃; for 5h; Yield given;	A 80% B 72% C n/a D n/a

...Expand

: 29625-73-8
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-N-(4-L-aspartoyl)-2-deoxy-β-D-glucopyranosylamine

A: 672-15-1
L-homoserine

B: 102039-77-0
N,N'-diacetylchitobiosamine

C: 118943-00-3
1-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-2-amino-1,2-dideoxy-D-glucitol

D: 119009-35-7
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-amino-1,2-dideoxy-D-glucitol

E: 29886-32-6
β-D-GlcpNAc(1->4)-D-GlcNAc-ol

Conditions

Conditions	Yield
With lithium hydroxide; lithium borohydride; trilithium citrate In water; tert-butyl alcohol at 45℃; for 5h; Product distribution;	A 80% B 72% C n/a D n/a E 5%

...Expand

: 29625-73-8
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-N-(4-L-aspartoyl)-2-deoxy-β-D-glucopyranosylamine

A: 672-15-1
L-homoserine

B: 102039-77-0
N,N'-diacetylchitobiosamine

C: 119009-35-7
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-amino-1,2-dideoxy-D-glucitol

D: 29886-32-6
β-D-GlcpNAc(1->4)-D-GlcNAc-ol

Conditions

Conditions	Yield
With lithium hydroxide; lithium borohydride; trilithium citrate In water; tert-butyl alcohol at 45℃; for 5h;	A 80% B 72% C n/a D 5%

...Expand

: 63-68-3
L-methionine

: 672-15-1
L-homoserine

Conditions

Conditions	Yield
With water; methyl iodide at 20℃; for 24h; Inert atmosphere; Reflux;	74%
Stage #1: L-methionine With methyl iodide In water for 24h; Inert atmosphere; Stage #2: With potassium hydrogencarbonate for 10h; pH=3 - 6; Reflux; Stage #3: With hydrogenchloride In water pH=5 - 6;	74%
Stage #1: L-methionine With methyl iodide In methanol; water for 48h; Stage #2: With sodium hydrogencarbonate In methanol; water for 15h; Reflux;	62%
With sodium hydrogencarbonate; methyl iodide In methanol; water for 12h; Reflux;

: 1149755-80-5
(S)-tert-butyl 1-(furan-2-yl)-3-hydroxypropylcarbamate

: 672-15-1
L-homoserine

Conditions

Conditions	Yield
Stage #1: (S)-tert-butyl 1-(furan-2-yl)-3-hydroxypropylcarbamate With ozone In methanol at -78℃; for 0.166667h; Stage #2: With dimethylsulfide In methanol at 20℃; for 12h; Stage #3: With hydrogenchloride In 1,4-dioxane at 0 - 20℃;	62%

: 63-68-3
L-methionine

: 87625-62-5
ptaquiloside

A: 672-15-1
L-homoserine

B: 34175-96-7
2(R)-pterosin B

C: 114751-11-0
(R)-2,5,7-Trimethyl-6-(2-methylsulfanyl-ethyl)-indan-1-one

D: 114751-12-1
(S)-2-Amino-4-methylsulfanyl-butyric acid 2-((R)-2,4,6-trimethyl-3-oxo-indan-5-yl)-ethyl ester

Conditions

Conditions	Yield
With sodium hydroxide; Amberlite CG 50 (H form) In water; acetone at 37℃; for 12h; 1.) pH: 9.2;	A 10% B 26% C 12% D 4%

...Expand

: 29625-73-8
2-acetamido-4-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-1-N-(4-L-aspartoyl)-2-deoxy-β-D-glucopyranosylamine

A: 672-15-1
L-homoserine

B: 56-84-8
L-Aspartic acid

C: 29886-32-6
β-D-GlcpNAc(1->4)-D-GlcNAc-ol

Conditions

Conditions	Yield
With sodium hydroxide; sodium tetrahydroborate	A 15% B 3% C 20%

...Expand

Raw Materials

64-18-6

56-40-6

50-00-0

16856-13-6

Downstream Products

56-84-8

63-68-3

Total:127 Page 1 of 4 1 2 3 4 Next>>

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Chemistry

IUPAC Name: 2-Amino-4-hydroxybutanoic acid
Synonyms of L-Homoserine (CAS NO.672-15-1): Butanoic acid, 2-amino-4-hydroxy-, (S)- ; Homoserine (VAN) ; Butyric acid, 2-amino-4-hydroxy-, L- (8CI)
CAS NO: 672-15-1
Molecular Formula: C₄H₉NO₃
Molecular Weight: 119.12
Molecular Structure:
EINECS: 211-590-6
H bond acceptors: 4
H bond donors: 4
Freely Rotating Bonds: 5
Polar Surface Area: 38.77 Å²
Index of Refraction: 1.51
Molar Refractivity: 27.17 cm³
Molar Volume: 90.7 cm³
Surface Tension: 63.5 dyne/cm
Density: 1.312 g/cm³
Flash Point: 176.8 °C
Enthalpy of Vaporization: 71.22 kJ/mol
Boiling Point: 368.7 °C at 760 mmHg
Vapour Pressure: 6.16E-07 mmHg at 25°C
Melting Point: 203 °C (dec.)(lit.)
Alpha: -8.5 º (c=2, H₂O 22 ºC)
Storage temp: Store at RT.
Water Solubility: 1100 g/L (30 °C)
Appearance: white to light yellow crystalline powder
Product Categories of L-Homoserine (CAS NO.672-15-1): Serine [Ser, S];Unusual Amino Acids;Amino Acids;Amino Acids & Derivatives

Uses

L-Homoserine (CAS NO.672-15-1) is an intermediate in the biosynthesis of three essential amino acids: methionine, threonine (an isomer of homoserine), and isoleucine.

Safety Profile

Safety Information about L-Homoserine (CAS NO.672-15-1):
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 3
F: 10
HS Code: 29225000

Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container. Keep refrigerated. (Store below 4°C/39°F.)