Reference

Microbial production of S-(+)-(2-nitroalkyl)benzene

Microbial production of S-(+)-(2-nitroalkyl)benzene. (Sagami Chemical Research Center, Japan). Jpn. Kokai Tokkyo Koho JP 59132895 A2 31 Jul 1984 Showa, 7 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C12P013-00; C07C079-02; C07C079-35. ICI: C12P013-00, C12R001-32; C12P013-00, C12R001-365. APPLICATION: JP 83-6665 20 Jan 1983. DOCUMENT TYPE: Patent CA Section: 16 (Fermentation and Bioindustrial Chemistry) S-(+)-(2-Nitroalkyl)benzene (I; R=lower alkyl; R1=H, OH, Cl, trifluoromethyl, lower alkoxy, lower alkyl) were prepd. by stereoselective redn. of the corresponding 2-nitro-1-phenylalkene with Mycobacterium or Nocardia. Thus, Nocardia corallina was inoculated into 100 mL medium (pH 7) contg. glucose 10, peptone 7, yeast ext. 5, and K2HPO4 5 g/L and shake-cultured at 30° for 2 days. To this culture (pH 6), 100 mg 2-nitro-1-phenyl-1-propene [705-60-2] dissolved in 1 mL acetone was added and the incubation was continued for 2 days. The broth was brought to pH 1.5-2 with H2SO4, extd. with EtOAc and the ext. dried and chromatographed on silica gel to give a 85% yield of S-(+)-(2-nitropropyl)benzene [92998-95-3]. Similarly prepd. was S-(+)-4-hydroxy-1-(2-nitropropyl) benzene [92915-65-6].

Some natural synthetic growth inhibiting substances detected with a "Jerusalem artichoke slice test"

Some natural synthetic growth inhibiting substances detected with a "Jerusalem artichoke slice test". Chenieux, J. C.; Rideau, M.; Peron, A. (Lab. Biol. Veg. Cellulaire, Fac. Pharm., Tours, Fr.). C. R. Seances Soc. Biol. Ses Fil., 171(1), 233-40 (French) 1977. CODEN: CRSBAW. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemicals) The modified Jerusalem artichoke (Helianthus tuberosus) disk test (Adamson, D., et al., 1972) was verified using a large no. of plant-growth regulation and antimitotic agents. For growth inhibitors, the test was less sensitive than the Jerusalem artichoke tissue culture test. Teree new cytotoxic agents, i.e. .beta.-methyl-.beta.-nitrostyrene [705-60-2] (Viel, C. and Dore, J. C., 1972), balfourodinium chloride [39057-14-2] and a ptelefolonium salt (Chemieux, J. C., et al., 1976) caused 50% disk growth inhibition at 2.5 .times. 10-4, 3 .times. 10-4, and 4 .times. 10-4M, resp. Disk growth stimulation by 2,4-D was parallelled by a continuous increase in the level of nucleic acids, in the case of growth inhibition by balfourodinium chloride, however, the nucleic acids started to decrease only after a 24-h lap period.