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CAS No.: | 7447-39-4 |
---|---|
Name: | Copper(II) chloride |
Article Data: | 3 |
Molecular Structure: | |
Formula: | CuCl2 |
Molecular Weight: | 134.452 |
Synonyms: | Copperbichloride;Copper(II) chloride;Copper dichloride;Copper(2+) chloride;Copper(II)chloride;Cupric chloride anhydrous;Cupric dichloride;GBC 4L;NSC 165706; |
EINECS: | 231-210-2 |
Density: | 3.386 g/cm3 |
Melting Point: | 498 °C |
Boiling Point: | 993 °C |
Solubility: | in water: 706 g/L (0 °C), 757 g/L (25 °C) |
Appearance: | Brownish yellow crystalline powder |
Hazard Symbols: | T, N |
Risk Codes: | 25-36/37/38-50/53 |
Safety: | 26-29-37/39-45-57 |
Transport Information: | UN 2802 8/PG 3 |
PSA: | 0.00000 |
LogP: | -5.99450 |
Conditions | Yield |
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In gaseous matrix passing of Cl2 in Ar gas (5%) over solid Cu(I)Cl (650°C, alumina crucible, backing pressure 1.5 atm); |
chlorine
copper
copper(II) chloride
Conditions | Yield |
---|---|
In neat (no solvent) copper wire was heated in a small excess of Cl2 in a sealed cell;; | |
In gaseous matrix passing of Cl2 in Ar gas (5%) over Cu powder (850°C, alumina crucible, backing pressure 1.5 atm); | |
In neat (no solvent) reaction of Cu powder with Cl2 gas at 750°C; laser induced fluorescence; |
1-Decene
magnesium sulfate
copper(II) chloride
2-methyl decanoic acid
Conditions | Yield |
---|---|
With hydrogenchloride; carbon monoxide In tetrahydrofuran; sodium hydroxide; water | 100% |
copper(II) chloride
3-chloro-1-isothiocyanato-1-propene
Conditions | Yield |
---|---|
In 5,5-dimethyl-1,3-cyclohexadiene | 90.7% |
3-chloro-1-hexene
copper(II) chloride
1,3-chlorobromopropane
6-chloronon-1-ene
Conditions | Yield |
---|---|
With lithium chloride In tetrahydrofuran | 84% |
4-bromo-2-iodoaniline
copper(II) chloride
4-bromo-1-chloro-2-iodobenzene
Conditions | Yield |
---|---|
With tert.-butylnitrite In acetonitrile | 76% |
tert.-butylnitrite
4-bromo-3-methyl-5-nitroaniline
copper(II) chloride
2-bromo-5-chloro-1-methyl-3-nitro-benzene
Conditions | Yield |
---|---|
In acetonitrile | 72% |
3-bromo-4-fluoroaniline
copper(II) chloride
3-bromo-4-fluorobenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride; sulfur dioxide In methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran | 59% |
tert.-butylnitrite
5-nitropyrimidin-2-amine
copper(II) chloride
2-Chloro-5-nitropyrimidine
Conditions | Yield |
---|---|
With magnesium sulfate In diethyl ether; acetonitrile | 50% |
tert.-butylnitrite
5-Amino-4-(2'-methyl-biphenyl-3-sulfonyl)-thiophene-2-carboxylic acid methyl ester
copper(II) chloride
5-chloro-4-(2'-methyl-biphenyl-3-sulfonyl)-thiophene-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
In ethyl acetate; acetonitrile | 34% |
Copper and its compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory.
ACGIH TLV: TWA (fume) 0.2 mg/m3; (dust, mist) 1 mg(Cu)/m3
DOT Classification: 8; Label: Corrosive
Cupric chloride anhydrous, with the CAS register number 7447-39-4, is also called as Copper dichloride. The substance is a yellow-brown solid with the chemical formula CuCl2. Its EINECS register number is 231-210-2. Cupric chloride anhydrous is stable, but reacts violently with potassium and sodium. If contacts with acetylene may form explosive acetylides. Hygroscopic. This is a light brown solid, which slowly absorbs moisture to form a blue-green dihydrate.
Properties: Cupric chloride anhydrous reacts with hydrochloric acid or other chloride sources to form complex ions: the red CuCl3-, and the yellow CuCl42-. Using sulfur dioxide as the reductant, copper(II) chloride can be reduced into copper(I) derivatives.
2 CuCl2 + SO2 + 2 H2O → 2 CuCl + 2 HCl + H2SO4
Cupric chloride anhydrous will decompose to CuCl and Cl2 at 1000 °C:
2 CuCl2 → 2 CuCl + Cl2
Cupric chloride anhydrous also can form a variety of coordination complexes with ligands such as pyridine and triphenylphosphine oxide:
CuCl2 + 2 C5H5N → [CuCl2(C5H5N)2] (tetragonal)
CuCl2 + 2 (C6H5)3P=O → [CuCl2((C6H5)3P=O)2] (tetrahedral)
Preparation: Cupric chloride anhydrous may be prepared directly by union of the elements, copper and chlorine. It can also be generated by treatment of the hydroxide, oxide, or copper(II) carbonate with hydrochloric acid. In addition, Cupric chloride anhydrous is prepared commercially by the action of chlorination of copper:
Cu + Cl2 + 2 H2O → CuCl2(H2O)2
Uses: Cupric chloride anhydrous can be used as catalyst, antifungal and astringent drug, and feed additive. A major industrial application for Cupric chloride is as a co-catalyst with palladium(II) chloride in the Wacker process. In this process, ethene (ethylene) is converted to ethanal using water and air. During the reaction, PdCl2 is reduced to Pd, and the CuCl2 serves to re-oxidize this back to PdCl2. Air can then oxidize the resultant CuCl back to CuCl2, completing the cycle.
C2H4 + PdCl2 + H2O → CH3CHO + Pd + 2 HCl
Pd + 2 CuCl2 → 2 CuCl + PdCl2
4 CuCl + 4 HCl + O2 → 4 CuCl2 + 2 H2O
Cupric chloride anhydrous has a variety of specialized applications in the synthesis of organic compounds. It catalyzes the chlorination in the production of vinyl chloride and dichloroethane. Cupric chloride is also used in pyrotechnics as a blue/green coloring agent. In a flame test, Cupric chloride, like all copper compounds, emit green-blue. Cupric chloride can also oxidize phenols in the presence of oxygen.
When you are using Cupric chloride anhydrous, you should be very cautious about it. The substance is toxic if swallowed and dangerous for the environment. In addition, it is irritating to eyes, respiratory system and skin. Cupric chloride anhydrous is very toxic to aquatic organisms which may cause long-term adverse effects in the aquatic environment. In case of contact with eyes, you can rinse immediately with plenty of water and seek medical advice. Whenever you will use or contact it, you need wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: Cl[Cu]Cl
(2)InChI: InChI=1S/2ClH.Cu/h2*1H;/q;;+2/p-2
(3)InChIKey: ORTQZVOHEJQUHG-UHFFFAOYSA-L
Toxicity of Cupric chloride anhydrous:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 7400ug/kg (7.4mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 244, Pg. 17, 1962. | |
mouse | LD50 | intravenous | 17500ug/kg (17.5mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 19, Pg. 425, 1984. | |
mouse | LD50 | oral | 233mg/kg (233mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
rat | LD50 | intraperitoneal | 14700ug/kg (14.7mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
rat | LD50 | intravenous | 5mg/kg (5mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |
rat | LD50 | oral | 584mg/kg (584mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991. |