CAS No.74578-69-1,Ceftriaxone sodium Suppliers,MSDS download

Products Categories

Pharmaceutical (204)
Others (32)
Organic Chemicals (25)
Reagent (8)
Plant Extract (3)
Materials (2)
Food Additives (1)

Basic Information

Molecular Structure:
CAS No.:	74578-69-1
Name:	Ceftriaxone sodium
Article Data:	12

Formula:	C₁₈H₁₈N₈Na₂O₇S₃
Molecular Weight:	598.552
Synonyms:	5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-,disodium salt, [6R-[6a,7b(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-,disodium salt, (6R,7R)- (9CI);Acantex;Cefatriaxone;Ceftriaxone disodium;Ceftriaxone disodium salt;Cephtriaxone;Ceroneed;Disodiumceftriaxone;Lendacin;Longaceph;Monocef;Oframax;Ro 13-9904;Rocephin;Sefirom;Tartriakson;X 13-9904;Ceftriaxone Sodium Hydrate;
EINECS:	277-930-0
PSA:	296.63000
LogP:	-2.03600

Synthetic route

: C11H15N3O4S

: C12H13N5O5S2*C5H13N3

: 74578-69-1
ceftriaxone disodium

Conditions

Conditions	Yield
Stage #1: C11H15N3O4S; C12H13N5O5S2*C5H13N3 With sodium acetate In water at -50 - -40℃; for 1h; Stage #2: In acetone at 20 - 25℃; for 1h; Solvent; Reagent/catalyst;	97%

: 80756-85-0
(Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate

: 58909-56-1
7-aminoceftrizine

: 74578-69-1
ceftriaxone disodium

Conditions

Conditions	Yield
Stage #1: (Z)-S-benzo[d]thiazol-2-yl 2-(2-aminothiazol-4-yl)-2-(methoxyimino)ethanethioate; 7-aminoceftrizine With triethylamine In methanol at -2 - 3℃; Stage #2: With sodium 2-ethylhexanoic acid In water; isopropyl alcohol at 26 - 30℃; for 2h; Product distribution / selectivity;	95.5%
With sodium metabisulfite; edetate disodium; triethylamine In ethanol; water at 1 - 3℃; for 3h; Time;	91%

: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate

: 58909-56-1
7-aminoceftrizine

: 74578-69-1
ceftriaxone disodium

Conditions

Conditions	Yield
Stage #1: 7-aminoceftrizine With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 20℃; for 2h; Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In dichloromethane at 20℃; for 4h; Stage #3: With sodium hydroxide In dichloromethane; water at 15 - 20℃; pH=7.5 - 7.8;	94.6%
Stage #1: 7-aminoceftrizine With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at 20℃; for 2h; Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In dichloromethane at 20℃; for 18h;
Stage #1: 7-aminoceftrizine With N,O-bis-(trimethylsilyl)-acetamide In DMF (N,N-dimethyl-formamide) at 20℃; for 2h; Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In DMF (N,N-dimethyl-formamide) at 20℃; for 4h; Stage #3: With sodium hydroxide In DMF (N,N-dimethyl-formamide); water at 15 - 20℃; pH=7.5 - 7.8;
Stage #1: 7-aminoceftrizine With N,N'-bis(trimethylsilyl)urea In dichloromethane at 20℃; for 2h; Stage #2: diethylthiophosphoryl-(Z)-(2-aminothiazol-4-yl)methoxyimino acetate In dichloromethane at 20℃; for 10h; Stage #3: With sodium hydroxide In dichloromethane; water at 15 - 20℃; pH=7.5 - 7.8;

: 91868-79-0
2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid

: 58909-56-1
7-aminoceftrizine

: 74578-69-1
ceftriaxone disodium

Conditions

Conditions	Yield
Stage #1: 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid With isopropyl chloroformate; triethylamine In dichloromethane; acetonitrile at -5 - 20℃; for 5h; Stage #2: 7-aminoceftrizine In dichloromethane; acetonitrile at 20℃; for 6h;	89.18%

: 73384-59-5, 92143-31-2
ceftriaxone

: 74578-69-1
ceftriaxone disodium

Conditions

Conditions	Yield
Stage #1: ceftriaxone With triethylamine In water at 0 - 5℃; Stage #2: With sodium 2-ethylhexanoic acid In water; acetone at 0 - 5℃;	77%
With sodium 2-ethylhexanoic acid In water; acetone at -10 - 20℃; for 1.5h;
Stage #1: ceftriaxone With sodium 2-ethylhexanoic acid In water at 10 - 15℃; Stage #2: In water; acetone at 18 - 20℃; for 1.5h;
Stage #1: ceftriaxone With RELITE CNS carboxylic resin; sodium form of In water; acetone at 10℃; for 4h; Stage #2: In water

: 108260-00-0
7-aminocephalosporanic acid

: 74578-69-1
ceftriaxone disodium

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: acetonitrile 1.2: -15 °C 2.1: sodium acetate / water / 1 h / -50 - -40 °C 2.2: 1 h / 20 - 25 °C View Scheme

: gold(III) chloride

: 7732-18-5
water

: 74578-69-1
ceftriaxone disodium

: C18H16AuN8O7S3(1+)*Cl(1-)*4H2O

Conditions

Conditions	Yield
In methanol for 3h; Reflux;

...Expand

: 7732-18-5
water

: palladium dichloride

: 74578-69-1
ceftriaxone disodium

: C18H16N8O7PdS3*3H2O

Conditions

Conditions	Yield
In methanol for 3h; Reflux;

...Expand

: 7732-18-5
water

: 7646-85-7
zinc(II) chloride

: 74578-69-1
ceftriaxone disodium

: C18H20N8O9S3Zn*7H2O

Conditions

Conditions	Yield
In methanol for 3h; Reflux;

...Expand

: iron(III) chloride hexahydrate

: 7732-18-5
water

: 74578-69-1
ceftriaxone disodium

: C18H18ClFeN8O8S3*7H2O

Conditions

Conditions	Yield
In methanol for 3h; Reflux;

...Expand

Raw Materials

73384-59-5

80756-85-0

58909-56-1

Total:171 Page 1 of 5 1 2 3 4 5 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 74578-69-1

Specification

The Ceftriaxone Sodium is an organic compound with the formula C₁₈H₁₈N₈Na₂O₇S₃. The systematic name of this chemical is disodium (6R,7R)-7-[[(2Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. With the CAS registry number 74578-69-1, it is also named as Ceftriaxone disodium.

You can still convert the following datas into molecular structure:
(1)SMILES: Cn1c(nc(=O)c(n1)O)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/c4csc(n4)N)SC2)C(=O)O.[Na+].[Na+]
(2)InChI: InChI=1/C18H18N8O7S3.2Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);;/q;2*+1/b24-8-;;/t9-,15-;;/m1../s1
(3)InChIKey: FDRNWTJTHBSPMW-BBJOQENWBW
(4)Std. InChI: InChI=1S/C18H18N8O7S3.2Na/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32);;/q;2*+1/b24-8-;;/t9-,15-;;/m1../s1
(5)Std. InChIKey: FDRNWTJTHBSPMW-BBJOQENWSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	> 3gm/kg (3000mg/kg)		Drugs in Japan Vol. -, Pg. 676, 1995.
infant	TDLo	intramuscular	16mg/kg/3D-I (16mg/kg)	BRAIN AND COVERINGS: MENINGEAL CHANGES BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT	Clinical Pediatrics Vol. 32, Pg. 360, 1993.
man	TDLo	multiple routes	800mg/kg/49D- (800mg/kg)	BLOOD: AGRANULOCYTOSIS BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT	Israel Journal of Medical Sciences. Vol. 29, Pg. 52, 1993.
mouse	LD50	intravenous	2200mg/kg (2200mg/kg)		Journal of Antibiotics. Vol. 33, Pg. 783, 1980.
mouse	LD50	oral	> 10gm/kg (10000mg/kg)		"Ceftriaxon Vol. -, Pg. 91, 1982.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		"Ceftriaxon Vol. -, Pg. 91, 1982.
rat	LD50	intravenous	1900mg/kg (1900mg/kg)		"Ceftriaxon Vol. -, Pg. 91, 1982.
rat	LD50	oral	> 10gm/kg (10000mg/kg)		"Ceftriaxon Vol. -, Pg. 91, 1982.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		"Ceftriaxon Vol. -, Pg. 91, 1982.
women	TDLo	multiple routes	640mg/kg/32D- (640mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: AGRANULOCYTOSIS	Israel Journal of Medical Sciences. Vol. 29, Pg. 52, 1993.