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CAS No.: | 74892-82-3 |
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Name: | Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate |
Article Data: | 6 |
Molecular Structure: | |
Formula: | C9H17NO2 |
Molecular Weight: | 171.239 |
Synonyms: | 2-Piperidinecarboxylicacid, 4-methyl-, ethyl ester, (2R-trans)-;(2R,4R)-4-Methyl-2-piperidinecarboxylicacid ethyl ester;2-Piperidinecarboxylicacid, 4-methyl-, ethyl ester, (2R,4R)-; |
EINECS: | 1806241-263-5 |
Density: | 0.969 g/cm3 |
Boiling Point: | 226.1 °C at 760 mmHg |
Flash Point: | 90.5 °C |
PSA: | 38.33000 |
LogP: | 1.26640 |
ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate L-(+)-tartarate
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
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With potassium carbonate In water; ethyl acetate at 15 - 20℃; for 1h; | 88% |
ethyl (2R,4R)-4-methyl-1-((S)-1-phenylethyl)tetrahydropyridine-2-carboxylate
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
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With 10% palladium hydroxide on charcoal; hydrogen In ethanol at 20℃; under 760.051 Torr; for 4h; | 45% |
With palladium 10% on activated carbon; hydrogen; iron(II) oxalate; acetic acid In ethanol at 30℃; under 3750.38 Torr; for 4h; Reagent/catalyst; Autoclave; | 345 g |
(2R,4R)-4-Methyl-1-((R)-1-phenyl-ethyl)-piperidine-2-carboxylic acid ethyl ester
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
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With hydrogen; palladium hydroxide - carbon In ethanol under 760 Torr; Ambient temperature; |
(6R)-1-<(R)-1-phenylethyl>-6-ethoxycarbonyl-4-methyl-3,4-didehydropiperidine
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
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Multi-step reaction with 2 steps 1: H2 / 3percent Pt-C / ethyl acetate / 16 h / 760 Torr / Ambient temperature 2: H2 / Pd(OH)2-C / ethanol / 760 Torr / Ambient temperature View Scheme |
isoprene
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: TFA, H2O / dimethylformamide / 30 h / Ambient temperature 2: H2 / 3percent Pt-C / ethyl acetate / 16 h / 760 Torr / Ambient temperature 3: H2 / Pd(OH)2-C / ethanol / 760 Torr / Ambient temperature View Scheme |
ethyl (2R)-4-methyl-1-((S)-1-phenylethyl)-1,2,3,6-tetrahydropyridine-2-carboxylate
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
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Multi-step reaction with 2 steps 1: (SP, S′P)-1,1′-bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-α-(dimethylamino)benzyl]ferrocene; bis(norbornadiene)rhodium(l)tetrafluoroborate; methanesulfonic acid; hydrogen / ethanol / 18 h / 90 °C / 7500.75 Torr / Autoclave 2: 10% palladium hydroxide on charcoal; hydrogen / ethanol / 4 h / 20 °C / 760.05 Torr View Scheme | |
Multi-step reaction with 2 steps 1: 3 % platinum on carbon; hydrogen / ethyl acetate / 48 h / 20 °C / 760.05 Torr 2: 10% palladium hydroxide on charcoal; hydrogen / ethanol / 4 h / 20 °C / 760.05 Torr View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
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With potassium carbonate In water; ethyl acetate at 20℃; for 1h; |
4-methylpiperidin
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
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Multi-step reaction with 7 steps 1.1: acetic acid; sodium hypochlorite / water / 2 h / 0 - 10 °C 1.2: 0 - 20 °C 2.1: hydrogenchloride / water; dichloromethane / 1.5 h / 0 - 10 °C 3.1: water; dichloromethane / 0 - 20 °C 4.1: hydrogenchloride / water / 20 - 60 °C 5.1: thionyl chloride / 0 °C / Reflux 6.1: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate 7.1: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme |
2,3,4,5-tetrahydro-4-methylpyridine
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
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Multi-step reaction with 6 steps 1: hydrogenchloride / water; dichloromethane / 1.5 h / 0 - 10 °C 2: water; dichloromethane / 0 - 20 °C 3: hydrogenchloride / water / 20 - 60 °C 4: thionyl chloride / 0 °C / Reflux 5: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate 6: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme |
ethyl (2R-trans)-4-methylpiperidine-2-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: water; dichloromethane / 0 - 20 °C 2: hydrogenchloride / water / 20 - 60 °C 3: thionyl chloride / 0 °C / Reflux 4: ethanol; acetone / 0.5 h / 40 °C / Resolution of racemate 5: potassium carbonate / water; ethyl acetate / 1 h / 15 - 20 °C View Scheme |
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Molecule structure of Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate (CAS NO.74892-82-3):
Molecular Weight: 171.24 g/mol
Molecular Formula: C9H17NO2
Density: 0.969 g/cm3
Boiling Point: 226.1 °C at 760 mmHg
Flash Point: 90.5 °C
Index of Refraction: 1.441
Molar Refractivity: 46.69 cm3
Molar Volume: 176.5 cm3
Surface Tension: 29.2 dyne/cm
Enthalpy of Vaporization: 46.26 kJ/mol
Vapour Pressure: 0.0835 mmHg at 25 °C
InChI: InChI=1/C9H17NO2/c1-3-12-9(11)8-6-7(2)4-5-10-8/h7-8,10H,3-6H2,1-2H3/t7-,8-/m1/s1
InChIKey of Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate (CAS NO.74892-82-3): GHBNOCBWSUHAAA-HTQZYQBOBF
Ethyl (2R,4R)-4-methyl-2-piperidinecarboxylate (CAS NO.74892-82-3) is also named as 2-piperidinecarboxylic acid, 4-methyl-, ethyl ester, (2R,4R)- ; Ethyl (2R,4R)-4-methylpiperidine-2-carboxylate ; (2R,4R)-4-Methyl-2-piperidinecarboxylate .