Detail of "94-59-7"

Reference

Comparison of percutaneous absorption of fragrances by humans and monkeys

Comparison of percutaneous absorption of fragrances by humans and monkeys. Bronaugh, R. L.; Stewart, R. F.; Wester, R. C.; Bucks, D.; Maibach, H. I.; Anderson, J. (Div. Toxicol., Food Drug Adm., Washington, DC 20204, USA). Food Chem. Toxicol., 23(1), 111-14 (English) 1985. CODEN: FCTOD7. ISSN: 0278-6915. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Section cross-reference(s): 4 The percutaneous absorption of 2 cosmetic fragrance materials, safrole [94-59-7] and cinnamyl anthranilate [87-29-6], as well as of cinnamic alc. [104-54-1] and cinnamic acid [621-82-9] was measured at occluded and nonoccluded application sites. Absorption values were detd. in the rhesus monkey in vivo. Absorption through human skin was measured by using excised skin in diffusion cells. Because of the insol. in water of safrole and cinnamyl anthranilate, a nonionic surfactant soln. (6% Oleth-20 [9004-98-2]) was used in the receptor chamber of the diffusion cell in order to facilitate partitioning. The relative volatility of the compds. was detd. to aid in the interpretation of the absorption results. The greatest difference between in vivo and in vitro absorption values occurred with safrole, which was the least well absorbed and the most volatile compd. Cinnamic acid absorption through nonoccluded human skin (17.8%) was significantly lower than monkey skin (38.6%). The values for absorption through human and monkey skin did not differ significantly for cinnamyl anthranilate (24.0 vs. 26.1%) or cinnamic alc. (33.9 vs. 25.4%). Occlusion of the skin resulted in greater permeation of all of the compds.; a significant decrease in permeability between the 2 types of skin occurred only with safrole. The fragrances were absorbed well, but their volatility must be considered in a toxicity evaluation. There was reasonable agreement between the values obtained from the studied of the human skin in vitro and the monkey skin in vivo.

Pharmacological influence of nutmeg and nutmeg constituents on rabbit platelet function

Pharmacological influence of nutmeg and nutmeg constituents on rabbit platelet function. Rasheed, A.; Laekeman, G. M.; Vlietinck, A. J.; Janssens, J.; Hatfield, G.; Totte, J.; Herman, A. G. (Dep. Pharm. Sci., Univ. Antwerp, Wilrijk 2610, Belg.). Planta Med., 50(3), 222-6 (English) 1984. CODEN: PLMEAA. ISSN: 0032-0943. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The pharmacol. properties of nutmeg components were investigated in relation to prostaglandin biosynthesis. Only the volatile oil contained the active principles. Several batches of oils showed the same antiaggregating activity on rabbit platelets aggregated with arachidonic acid. The most active products present in nutmeg oil were eugenol [97-53-0] and isoeugenol [97-54-1]; these arom. ethers were equipotent to indomethacin. Other active products, in decreasing order of potency, were the arom. ethers safrole [94-59-7], myristicin [607-91-0], and elemicin [487-11-6], the monoterpene hydrocarbon limonene [138-86-3], and the monoterpene alcs. a-terpineol [98-55-5], terpinen-4-ol [562-74-3], and linalool [78-70-6]. The major monoterpene hydrocarbons including a- [80-56-8] and b-pinene [127-91-3] and camphene [79-92-5], which constitute ~50% of the oil, however, were inactive.