Detail of "947-91-1"

Reference

Structure-activity studies on antidepressant 2,2-diarylethylamines

Structure-activity studies on antidepressant 2,2-diarylethylamines. Maryanoff, Bruce E.; Nortey, Samuel O.; Gardocki, Joseph F. 90530-67-9 is the cas registry number. This chemical is also mentioned in this article. (Dep. Chem. Biol. Res., McNeil Pharm., Spring House, PA 19477, USA). J. Med. Chem., 27(8), 1067-71 (English) 1984. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 25 The title compds. and the diethanol derivs. R1R2CR3CHR4NR5R6 (R1 = R2 = (un)substituted Ph, thienyl; R3 = H, F, OH, Me; R4 = H, Me, Et; R5 = R6 = H, Me, 2-hydroxy- or 2-acetoxy-1-ethyl) as their salts were prepd. and evaluated for antidepressant activity in the mouse tetrabenazine test. The diarylethylamines were prepd. from the appropriate diarylacetic acid, and the diethanol derivs. were prepd. either the diarylethylamines and ethylene oxide [75-21-8] or from diphenylacetaldehyde [947-91-1] and diethanolamine [111-42-2]. 2,2'-[(2,2-Diphenylethyl)imino]bisethanol-HCl [90530-63-5] and N,N-dimethyl-2,2-diphenylethylamine-HCl [13636-10-7] showed activity as potential antidepressants. Structure activity relations are discussed. .

Spiro[oxathiazolidine-quinuclidine] derivatives

Spiro[oxathiazolidine-quinuclidine] derivatives. (Israel, State of, Israel). Jpn. Kokai Tokkyo Koho JP 61280497 A2 11 Dec 1986 Showa, 48 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: C07D497-20. ICS: A61K031-435. ICA: C07D453-02. ICI: C07D497-20, C07D221-00, C07D327-00. APPLICATION: JP 86-98429 30 Apr 1986. PRIORITY: IL 85-75166 10 May 1985; IL 86-77568 10 Jan 1986. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The title compds. 3-hydroxy-3-(mercaptomethyl)quinuclidine (I), and II [X = CR1R2; R1, R2 = H, alkyl substituted by alkyl, cyclopentyl, cyclohexyl, (one or more than one)aryl, diarylmethylol (except R1 = R2 = H)], or their stereoisomers, enantiomers, diastereomers, racemates and their acid salts, useful for treatment of central nervous system ailments in mammals, Alzheimer's disease and useful as cholinergics, were prepd. Thus, treatment of 0.8 mol quinuclidin-3-one with 0.97 mol Me3S+(O)I- in petroleum ether/DMSO contg. 0.88 NaH at 50° for 2 h gave 100 g cis- and trans-2-methylspiro[1,3-oxathiolan-5',3-quinuclidine], whose reaction with H2S in aq. NaOH gave I. A soln. of 0.18 mol I and 1.There are some commonly used reagents with their cas registry numbers 107220-26-8 and 947-91-1 in this article.97 mol MeCHO in CH2Cl2 in presence of 0.11 mol BF3×Et2O was allowed to react at 25° for 3 h to give, after treatment with HCl(g), 62% cis- and trans-II.HCl (X = CHMe). These at 50% inhibitory concns. (3 and 4 ′ 10-7 M) in vitro were more effective than 3H-pirenzepine in binding to muscarine receptors in homogenized rat cerebral cortex. .