Reference

Effects of N-acetylaspartic acid and N-acetylaspartylglutamic acid applied iontophoretically to some rat neural structures

Effects of N-acetylaspartic acid and N-acetylaspartylglutamic acid applied iontophoretically to some rat neural structures. Avoli, M.; Barra, P. F. A.; Brancati, A.; Cecchi, L.; Deodati, M. (Univ. Roma, Rome, Italy). Boll. Soc. Ital. Biol. Sper., 52(18), 1525-30 (Italian) 1976. CODEN: BSIBAC. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Iontophoretic application of N-acetylaspartic acid [997-55-7] to 4 specific sites in the rat brain reduced the frequency of spontaneous discharge of individual neurons. The percentages of neurons responding were 80, 75, 75, and 25% in the cerebellar cortex, cerebral cortex, thalamus, and mesencephalon, resp. The percentages of neurons responding to application of N-acetylaspartylglutamic acid [3106-85-2] were 100, 90, 50, and 50% in the mesencephalon, cerebellar cortex, cerebral cortex, and thalamus, resp. However, in the cerebral cortex and mesencephalon, some of the neurons responded to this compd. in a stimulatory, rather than an inhibitory, fashion. The above order of neuronal susceptibility to the 2 compds. followed those of the distribution of the resp. substances along the rat neuraxis, where the concn. of N-acetylaspartic acid decreases in the rostrocaudal direction and the concn. of N-acetylaspartylglutamic acid decreases in the opposite direction.

Experimental study of the effects of six nonamphetaminic psychostimulants on effort hyperammoniaemia of rats

Experimental study of the effects of six nonamphetaminic psychostimulants on effort hyperammoniaemia of rats. Guinard, Francis; Foussard-Blanpin, Odette (Lab. Pharmacodyn., UER Sci. Pharm., Tours F 37032, Fr.). Ann. Pharm. Fr., 42(3), 265-70 (French) 1984. CODEN: APFRAD. ISSN: 0003-4509. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) L-Glutamic acid [56-86-0], L-arginine L-glutamate [4320-30-3], demanyl phosphate [6909-62-2], L-arginine-L-aspartate [7675-83-4], demanyl N-acetylglutamate [3342-61-8], and N-acetylaminosuccinic acid [997-55-7] increased resistance to fatigue of rats subjected to swimming tests. All compds., except demanyl phosphate, decreased the exercise-induced hyperammonemia. Thus, the antifatigue action of the psychostimulants appears related to an effect on NH3 detoxication.