822-89-9Relevant articles and documents
Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors
Jourden, Jody L. Major,Daniel, Kevin B.,Cohen, Seth M.
supporting information; experimental part, p. 7968 - 7970 (2011/08/07)
A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.
Enzymatic activation of a matrix metalloproteinase inhibitor
Major Jourden, Jody L.,Cohen, Seth M.
experimental part, p. 1241 - 1243 (2010/06/15)
Matrix metalloproteinase inhibitors (MMPi) possessing a glucose protecting group on the zinc-binding group (ZBG) show a dramatic increase in inhibitory activity upon cleavage by β-glucosidase.
Photoinduced heterolysis of the carbon-oxygen bond in bichromophoric 1- arylmethyloxy-2-pyridones
Sakurai, Tadamitsu,Kubo, Kanji,Kojima, Shunsuke,Shoro, Takuya,Inoue, Hiroyasu
, p. 9747 - 9750 (2007/10/03)
Irradiation of the title compound having a 9-anthryl (1a) or a 1- pyrenyl group (1b) in methanol was found to give the heterolytic C-O bond cleavage products: 1-hydroxy-2-pyridone and arylmethyl methyl ether, (which predominate for the reaction of 1a), along with 2-pyridone, aryl-substituted methanol and aryl aldehyde derived from the homolysis of the N-O bond (that mainly occurs in the photolysis of 1b). Spectroscopic analysis of the ground- state and excited singlet-state behavior of 1 revealed that a non-emissive intramolecular exciplex (whose formation rate is much faster in 1a than in 1b) plays a key role in inducing the C-O bond heterolysis.