Basic information
- Name:
p-Toluidine
- CAS No.:
106-49-0
- Molecular Structure:
- Formula:
- C7H9N
- Molecular Weight:
- 107.17
- Deleted CAS:
- 12221-03-3
- Synonyms:
- 1-Amino-4-methylbenzene;4-Aminotoluene;4-Methyl-1-aminobenzene;4-Methylaniline;4-Methylbenzenamine;4-Methylphenylamine;4-Toluidine;4-Tolylamine;Benzenamine,4-methyl-;C.I. Azoic Coupling Component 107;Naphthol AS-KG;Naphtol AS-KG;Naphtol AS-KGLL;p-Aminotoluene;p-Methylaniline;p-Methylbenzenamine;p-Methylphenylamine;p-Tolylamine;DHET;Para Toluidine;
- EINECS:
- 203-403-1
- Density:
- 0.992 g/cm3
- Melting Point:
- 43 ºC
- Boiling Point:
- 197.4 ºC at 760 mmHg
- Flash Point:
- 84.5 ºC
- Solubility:
- 1.1 g/100 mL in water
- Appearance:
- white lustrous plates or leaflets with an amine odour
- Hazard Symbols:
T,
N- Risk Codes:
- 23/24/25-36-40-43-50
- Safety Description:
- 28-36/37-45-61-28A Details
- Transport Information:
- UN 3451 6.1/PG 2
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Chemistry
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IUPAC Name: 4-Methylaniline
Molecular Formula: C7H9N
Molecular Weight: 107.15 g/mol
Canonical SMILES: c1(ccc(N)cc1)C
InChI: InChI=1/C7H9N/c1-6-2-4-7(8)5-3-6/h2-5H,8H2,1H3
EINECS: 203-403-1
Classification Code: Mutation data; Skin / Eye Irritant
Product Categories: Intermediates of Dyes and Pigments;Intermediates; Azo dye; API intermediates; Anilines (Building Blocks for Liquid Crystals); Building Blocks for Liquid Crystals; Functional Materials
Stability: Stable. Incompatible with strong oxidizing agents, strong acids.
Density: 0.992 g/cm3
Flash Point: 84.5 °C
Enthalpy of Vaporization: 43.36 kJ/mol
Boiling Point: 197.4 °C at 760 mmHg
Melting Point: 43 °C
Water Solubility: 1.1 g/100 mL
Storage temperature: 2-8 °C
Vapour Pressure of p-Toluidine (CAS NO.106-49-0): 0.379 mmHg at 25 °C
Uses
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - wild | LD50 | oral | 42mg/kg (42mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
| mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | National Technical Information Service. Vol. AD691-490, | |
| mouse | LD50 | oral | 330mg/kg (330mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(8), Pg. 50, 1981. | |
| quail | LD50 | oral | 237mg/kg (237mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
| rabbit | LD50 | oral | 270mg/kg (270mg/kg) | Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #4035-77, | |
| rabbit | LD50 | skin | 890mg/kg (890mg/kg) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 31-4/1973, | |
| rat | LC50 | inhalation | > 640mg/m3/1H (640mg/m3) | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 31-4/1973, | |
| rat | LD50 | oral | 336mg/kg (336mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Bromatologia i Chemia Toksykologiczna. Vol. 17, Pg. 51, 1984. |
Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
Confirmed carcinogen. Poison by ingestion and intraperitoneal routes. Mutation data reported. A severe skin and eye irritant. Flammable when exposed to heat, flame, or oxidizers. Can react vigorously on contact with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of NOx.
Hazard Codes: 
T,
N
Risk Statements: 23/24/25-36-40-43-50
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R36: Irritating to eyes.
R40: Limited evidence of a carcinogenic effect.
R43: May cause sensitization by skin contact.
R50: Very toxic to aquatic organisms.
Safety Statements: 28-36/37-45-61
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 3451 6.1/PG 2
WGK Germany: 2
RTECS: XU3150000
HazardClass: 6.1
PackingGroup of p-Toluidine (CAS NO.106-49-0): II
Specification
p-Toluidine (CAS NO.106-49-0), its Synonyms are 4-Aminotoluene ; 4-Toluidine ; 1-Amino-4-methylbenzene ; 4-Amino-1-methylbenzene ; 4-Methylaniline ; 4-Methylbenzenamine ; Aniline, p-methyl- ; Benzenamine, 4-methyl- ; p-Methylbenzenamine . It is white lustrous plates or leaflets with an amine odour.