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Name	1,1,1,3,3,3-Hexafluoro-2-(trifluoro-methyl)-2-propanol	EINECS	N/A
CAS No.	2378-02-1	Density	1.67g/cm³
PSA	20.23000	LogP	2.40440
Solubility	N/A	Melting Point	-17°C
Formula	C4H F9 O	Boiling Point	45 °C(lit.)
Molecular Weight	236.037	Flash Point	5.1°C
Transport Information	N/A	Appearance	clear colorless liquid
Safety	Low toxicity by inhalation. When heated to decomposition it emits toxic vapors of F⁻.	Risk Codes	20-36/37/38-23
Molecular Structure		Hazard Symbols	Xn,Xi,T
Synonyms	1,1,1,3,3,3-Hexafluoro-2-(trifluoromethyl)-2-propanol;2,2,2-Trifluoro-1,1-bis(trifluoromethyl)ethanol; 2-(Trifluoromethyl)-1,1,1,3,3,3-hexafluoro-2-propanol;Nonafluoro-tert-butanol; Nonafluoro-tert-butyl alcohol; Perfluoro tert-butylalcohol; Perfluoro(2-methyl-2-propanol); Perfluoro-tert-butanol;Perfluoro-tert-butyl alcohol; TBOL; Tris(trifluoromethyl)methanol	Article Data	26

1,1,1,3,3,3-Hexafluoro-2-(trifluoro-methyl)-2-propanol Synthetic route

: 7440-69-9
bismuth

: 27579-40-4
tris-(trifluoromethyl)methyl hypochlorite

A: 88392-03-4
Bi(3+)*3(CF3)3CO(1-) = Bi{(CF3)3CO}3

B: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

Conditions

Conditions	Yield
byproducts: (CF3)2CO, CF3Cl, Cl2; reaction mixt. maintained at 0°C for 40 h and at room temp. for 94 h and between 25 and 30°C for 6 h; addn. of additional (CF3)3COCl; volatiles removed at room temp. under vac.; elem. anal.;	A 93% B n/a

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 684-16-2
Hexafluoroacetone

: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

Conditions

Conditions	Yield
With potassium fluoride In acetonitrile Mechanism; a) 9 h, -40 deg C, b) 3 h, 18 deg C; other carbonyl compounds, variation of conditions: xfluorinated tertiary alcohols and alkoxides from nucleophilic trifluoromethylation of carbonyl compounds;	91.3%
With potassium fluoride In acetonitrile 1) -40 deg C, 9 h, 2) 18 deg C, 3 h;	91.3%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 407-25-0
trifluoroacetic anhydride

: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

Conditions

Conditions	Yield
With tetramethylammonium fluoride In 1,2-dimethoxyethane at -30 - 20℃;	87%

: 7594-49-2
1,1,1-trichloro-3,3,3-trifluoro-2-(trifluoromethyl)propan-2-ol

: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

Conditions

Conditions	Yield
With antimony pentafluoride for 3h; Heating;	85%
With antimony pentafluoride

: 353-50-4
Carbonyl fluoride

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

Conditions

Conditions	Yield
With potassium fluoride In acetonitrile for 18h; -40 deg C to r.t.;	77.1%

: 2809-92-9
nanofluoro-tert-butylamine

: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

Conditions

Conditions	Yield
With trifluoroacetic acid; sodium nitrite In water at 20℃; for 1h;	70%

: 75-38-7
Vinylidene fluoride

: 178984-96-8
C4BrF9O

A: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

B: 684-16-2
Hexafluoroacetone

C: 2-(2-Bromo-1,1-difluoro-ethoxy)-1,1,1,3,3,3-hexafluoro-2-trifluoromethyl-propane

D: 2-(2,2-Dibromo-1,1-difluoro-ethoxy)-1,1,1,3,3,3-hexafluoro-2-trifluoromethyl-propane

Conditions

Conditions	Yield
at -88 - 24℃; for 12h; Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;	A n/a B n/a C 31% D n/a
at -88 - 24℃; for 12h; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 178984-96-8
C4BrF9O

A: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

B: 684-16-2
Hexafluoroacetone

C: 2-(2-Bromo-1,1-difluoro-ethoxy)-1,1,1,3,3,3-hexafluoro-2-trifluoromethyl-propane

D: 2-(2,2-Dibromo-1,1-difluoro-ethoxy)-1,1,1,3,3,3-hexafluoro-2-trifluoromethyl-propane

Conditions

Conditions	Yield
at -88 - 24℃; for 12h; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

: CH3C6H3CH2OS(OC(CF3)3)2

: 1493-13-6
trifluorormethanesulfonic acid

A: CH3C6H3CH2OSCO(CF3)3(1+)*CF3SO3(1-)

B: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

: 71212-59-4
bis(nonafluoro-tert-butoxy)(pentafluorophenylsulfanyl)trifluorophenylsulfur(IV)

: 7732-18-5
water

A: 2378-02-1
1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol

B: 1494-06-0
bis(pentafluorophenyl) disulfide

C: 63113-87-1
pentafluorophenyl pentafluorobenzenethiosulfonate

Conditions

Conditions	Yield
hydrolysis at 25°C;

1,1,1,3,3,3-Hexafluoro-2-(trifluoro-methyl)-2-propanol Chemical Properties

IUPAC Name: 1,1,1,3,3,3-Hexafluoro-2-(trifluoromethyl)propan-2-ol
The MF of Perfluoro-tert-butanol (CAS NO.2378-02-1) is C₄HF₉O.

The MW of Perfluoro-tert-butanol (CAS NO.2378-02-1) is 236.04.
Synonyms of Perfluoro-tert-butanol (CAS NO.2378-02-1): 2-Propanol, 1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)- ; Nonafluoro-tert-butanol ; Perfluoro-tert-butanol
Apperance: clear colorless liquid
Index of Refraction: 1.263
EINECS: 219-157-3
Density: 1.67 g/ml
Flash Point: 5.1 °C
Boiling Point: 84.7 °C
Melting Point: -17 °C
Storage temp: Keep Cold
BRN: 1841640

1,1,1,3,3,3-Hexafluoro-2-(trifluoro-methyl)-2-propanol Uses

Perfluoro-tert-butanol (CAS NO.2378-02-1) is used as chemical reagent, organic intermediates, fine chemicals, pharmaceutical research and development.

1,1,1,3,3,3-Hexafluoro-2-(trifluoro-methyl)-2-propanol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	10230mg/m3/2H (10230mg/m3)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 521, 1986.

1,1,1,3,3,3-Hexafluoro-2-(trifluoro-methyl)-2-propanol Safety Profile

Low toxicity by inhalation. When heated to decomposition it emits toxic vapors of F⁻.Safety information of Perfluoro-tert-butanol (CAS NO.2378-02-1):
Hazard Codes Harmful Xn,Xi, Toxic T
Risk Statements
20 Harmful by inhalation
36/37/38 Irritating to eyes, respiratory system and skin
23 Toxic by inhalation
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37 Wear suitable protective clothing and gloves
RIDADR UN 2810 6.1/PG 2
WGK Germany 3
RTECS UB6452700
Hazard Note Toxic

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