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Name	1,2,3-Trifluoro-4-nitrobenzene	EINECS	212-238-4
CAS No.	771-69-7	Density	1.554 g/cm³
PSA	45.82000	LogP	2.53530
Solubility	N/A	Melting Point	N/A
Formula	C₆H₂F₃NO₂	Boiling Point	201.8 °C at 760 mmHg
Molecular Weight	177.083	Flash Point	87 °C
Transport Information	UN 2810	Appearance	clear yellow liquid after melting
Safety	26-36/37/39-24/25	Risk Codes	20/21/22-36/37/38
Molecular Structure		Hazard Symbols	Xn,Xi
Synonyms	2,3,4-Trifluoro-1-nitrobenzene;2,3,4-Trifluoronitrobenzene;4-Nitro-1,2,3-trifluorobenzene;2.3.4-Dichloronitrobenzeme;	Article Data	12

1,2,3-Trifluoro-4-nitrobenzene Synthetic route

: 17700-09-3
4-nitro-1,2,3-trichlorobenzene

: 771-69-7
2,3,4-trifluoronitrobenzene

Conditions

Conditions	Yield
Stage #1: 4-nitro-1,2,3-trichlorobenzene With potassium fluoride; tetrabutylammomium bromide In dimethyl sulfoxide at 75 - 80℃; for 4h; Stage #2: With potassium fluoride; tetrabutyl ammonium fluoride In dimethyl sulfoxide at 75 - 180℃; for 12h; Time;	99.7%

: 2268-05-5
1,3-dichloro-2-fluorobenzene

: 771-69-7
2,3,4-trifluoronitrobenzene

Conditions

Conditions	Yield
Stage #1: 1,3-dichloro-2-fluorobenzene With sulfuric acid; nitric acid at 20 - 25℃; for 2.5h; Stage #2: With sulfolane; potassium fluoride for 5h;	85.5%
Multi-step reaction with 2 steps 1: sulfuric acid; aqueous nitric acid / 40 °C 2: dimethylformamide; potassium fluoride / 150 °C View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / 2 h / Heating 2: sulfolane; potassium fluoride / 8 h / 200 - 210 °C View Scheme

: 393-79-3
1,3-dichloro-2-fluoro-4-nitrobenzene

: 771-69-7
2,3,4-trifluoronitrobenzene

Conditions

Conditions	Yield
With potassium fluoride at 160 - 165℃; for 7h; Time;	85%
With potassium fluoride; immobilized pyridinium salt In sulfolane at 180℃; for 2h;	68%
With potassium fluoride; N,N-dimethyl-formamide at 150℃;
With sulfolane; potassium fluoride at 200 - 210℃; for 8h; Temperature;	124 g

: 1489-53-8
1,2,3-trifluorobenzene

: 771-69-7
2,3,4-trifluoronitrobenzene

: 163733-96-8
3,4,5-trifluoro aniline

: 771-69-7
2,3,4-trifluoronitrobenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrahydrofuran View Scheme

: anhydrous ethylene glycol dimethyl ether

trimethyl(ethoxypolyoxypropylmethyl ether)ammonium chloride: trimethyl(ethoxypolyoxypropylmethyl ether)ammonium chloride

: 393-79-3
1,3-dichloro-2-fluoro-4-nitrobenzene

: 3115-68-2
tetrabutyl phosphonium bromide

: 771-69-7
2,3,4-trifluoronitrobenzene

Conditions

Conditions	Yield
With potassium fluoride In 5,5-dimethyl-1,3-cyclohexadiene

: 95-50-1
1,2-dichloro-benzene

: 771-69-7
2,3,4-trifluoronitrobenzene

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: nitric acid; sulfuric acid / 2 h / 95 - 100 °C 2.1: potassium fluoride / 3 h / 140 - 150 °C 3.1: chlorine / 180 - 190 °C 4.1: nitric acid; sulfuric acid / 2.5 h / 20 - 25 °C 4.2: 5 h View Scheme

: 3209-22-1
1,2-Dichloro-3-nitrobenzene

: 771-69-7
2,3,4-trifluoronitrobenzene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: potassium fluoride / 3 h / 140 - 150 °C 2.1: chlorine / 180 - 190 °C 3.1: nitric acid; sulfuric acid / 2.5 h / 20 - 25 °C 3.2: 5 h View Scheme

: 2106-49-2
1-chloro-2-fluoro-3-nitrobenzene

: 771-69-7
2,3,4-trifluoronitrobenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: chlorine / 180 - 190 °C 2.1: nitric acid; sulfuric acid / 2.5 h / 20 - 25 °C 2.2: 5 h View Scheme

: 20098-48-0
3,4,5-trichloronitrobenzen

: 771-69-7
2,3,4-trifluoronitrobenzene

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride / 11 h / 140 - 175 °C 2.1: hydrogen / methanol / Inert atmosphere 3.1: nitrosylsulfuric acid / 6 h / 10 - 15 °C 3.2: 1 h 4.1: sulfuric acid; nitric acid / 2 h / Heating 5.1: sulfolane; potassium fluoride / 8 h / 200 - 210 °C View Scheme

1,2,3-Trifluoro-4-nitrobenzene Chemical Properties

The molecular formula of 1,2,3-Trifluoro-4-nitrobenzene(771-69-7) is C₆H₂F₃NO₂ and its formula weight is 177.08.
The density of 1,2,3-Trifluoro-4-nitrobenzene(771-69-7) is 1.541 g/mL at 25 °C(lit.) and it has a boiling point of 92 °C 20 mm Hg(lit.). The refractive index is about 1.492(lit.). Its flash point is 200 °F.
The chemical synonyms of 1,2,3-Trifluoro-4-nitrobenzene(771-69-7) are 4-NITRO-1,2,3-Trifluorobenzene;1,2,3-TRIFLUORO-4-NITROBENZENE;1,2,3-Trifluoro-4-nitrobenzene;2,3,4-TRIFLUORO-1-NITROBENZENE;3,4,5 TRIFLUORONITROBENZEN;2,3,4-TrifluorNITROBENZENE;4-chloro-2-fluroaniline;2,3,4-TRIFLUORONITROBRNZENE
The molecular structure of 1,2,3-Trifluoro-4-nitrobenzene(771-69-7):

1,2,3-Trifluoro-4-nitrobenzene Uses

Used as intermediates of drug ofloxacin, lomefloxacin, danofloxacin fluorine.

1,2,3-Trifluoro-4-nitrobenzene Toxicity Data With Reference

RTECS#: CAS# 771-69-7: None listed
LD50/LC50: RTECS: Not available.
Carcinogenicity: 1,2,3-Trifluoro-4-nitrobenzene - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: The toxicological properties have not been fully investigated.

1,2,3-Trifluoro-4-nitrobenzene Safety Profile

Safety Statements :
S26: In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S24/25: Avoid contact with skin and eyes

Hazard Codes Xn,Xi
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36/37/39-24/25
RIDADR UN2810
WGK Germany 3
Hazard Note Irritant
HazardClass 6.1
PackingGroup III

1,2,3-Trifluoro-4-nitrobenzene Specification

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials Strong oxidizing agents.
Hazardous Decomposition Products Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride gas.
Hazardous Polymerization Has not been reported.

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