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The IUPAC name of Urea,N,N'-bis(trimethylsilyl)- is 1,3-bis(trimethylsilyl)urea. With the CAS registry number 18297-63-7 and EINECS 242-177-9, it is also named as Bis(trimethylsilyl)urea. The product's categories are Trimethylsilylazide, etc.; Si (Classes of Silicon Compounds); Silicon Compounds (for Synthesis); Si-N Compounds; Synthetic Organic Chemistry; Blocking Agents; Protective Agents; Silazanes; Silylating Agents; Special Silanes. It is white solid which is sensitive to moisture. Additionally, this chemical should be sealed in the container, kept away from light and stored in the well-ventilated and dry place which must be away from oxidant and moisture.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.76; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.76; (4)ACD/LogD (pH 7.4): 1.76; (5)ACD/BCF (pH 5.5): 12.78; (6)ACD/BCF (pH 7.4): 12.78; (7)ACD/KOC (pH 5.5): 215.63; (8)ACD/KOC (pH 7.4): 215.63; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 23.55 Å2; (13)Index of Refraction: 1.427; (14)Molar Refractivity: 59.13 cm3; (15)Molar Volume: 230.3 cm3; (16)Polarizability: 23.44×10-24 cm3; (17)Surface Tension: 20.4 dyne/cm; (18)Density: 0.887 g/cm3.
Preparation of Urea,N,N'-bis(trimethylsilyl)-: It can be obtained by urea and 1,1,1,3,3,3-hexamethyl-disilazane. This reaction needs reagent saccharin and solvent ethyl acetate by heating. The reaction time is 20 min. The yield is 98.5%.
Uses of Urea,N,N'-bis(trimethylsilyl)-: This chemical, a good silane reagent, is used in the production of β-lactam antibiotics, cephalosporin IV and cephalosporins VI. It also can react with trifluoroacetyl chloride to get 1,3-bis-trifluoroacetyl-urea. The yield is 40%.
When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. So people should avoid contact with skin and eyes. It is also highly flammable. People must keep it away from ... (a list of incompatible materials will follow) and sources of ignition. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.
People can use the following data to convert to the molecule structure.
1. SMILES:O=C(N[Si](C)(C)C)N[Si](C)(C)C
2. InChI:InChI=1/C7H20N2OSi2/c1-11(2,3)8-7(10)9-12(4,5)6/h1-6H3,(H2,8,9,10)
3. InChIKey:MASDFXZJIDNRTR-UHFFFAOYAX