18297-63-7

Basic information

• Product Name: 1,3-Bis(trimethylsilyl)urea
• Synonyms: Urea, TMS;N,N'-BIS(TRIMETHYLSILYL)UREA;BIS(TRIMETHYLSILYL)UREA;BSU;N N'-BIS(TRIMETHYLSILYL)UREA 98+%;Hexamethyl disilaurea;Bis-(Trimethylsilyl)-Urea (BSU);Ureylenebis(trimethylsilane)
• CAS NO: 18297-63-7
• Molecular Formula: C₇H₂₀N₂OSi₂
• Molecular Weight: 204.42
• EINECS: 242-177-9
• Product Categories: Trimethylsilylazide, etc.;Si (Classes of Silicon Compounds);Silicon Compounds (for Synthesis);Si-N Compounds;Synthetic Organic Chemistry;Blocking Agents;Protective Agents;Silazanes;Silylating Agents;Special Silanes;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Ureas
• Mol File: 18297-63-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 219-221 °C(lit.)
• Boiling Point: 222°C
• Flash Point: 65°C
• Appearance: /solid
• Density: 0.887
• Vapor Pressure: 0.177mmHg at 25°C
• Refractive Index: 1.442
• Storage Temp.: 2-8°C
• Solubility: pyridine: soluble100mg/mL, clear to slightly hazy, colorless to
• PKA: 16.51±0.46(Predicted)
• Water Solubility: Reacts with water.
• Sensitive: Moisture Sensitive
• BRN: 1937452
• CAS DataBase Reference: 1,3-Bis(trimethylsilyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis(trimethylsilyl)urea(18297-63-7)
• EPA Substance Registry System: 1,3-Bis(trimethylsilyl)urea(18297-63-7)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-36/37/38-20/21/22
• Safety Statements: 14-16-24/25-36-26
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• F: 3-10-21
• TSCA: Yes
• Hazardous Substances Data: 18297-63-7(Hazardous Substances Data)

Usage

General Description

Silazane is any hydride of silicon and nitrogen having a straight or branched chain of silicon and nitrogen atoms joined by covalent bonds. By extension, the word is also used for any organic derivative of such compounds. They are analogous to siloxanes, with -NH- replacing -O-. Their individual name is dependent on the number of silicon atoms in the chemical structure. 1,3-Bis(trimethylsilyl)urea is an effective silylating agent. It is used in the pharmaceutical and in the chemical industry.

Chemical Properties

White solid with mild odor

Uses

N,N'-Bis(trimethylsilyl)urea is used as a reagent for the silylation of alcohols and carboxylic acids.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C7H20N2OSi2/c1-11(2,3)9(7(8)10)12(4,5)6/h1-6H3,(H2,8,10)

Upstream product

• 21149-38-2 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide 
• 77287-34-4 formamide 
• 57-13-6 urea 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 2083-91-2 N,N-Dimethyltrimethylsilylamine 

Downstream Products

• 18146-00-4 allyloxytrimethylsilane 
• 1177441-11-0 (S)-trimethyl(2-methylene-5-phenoxy-4-(trimethylsilyloxy)pentyl)silane 
• 1177441-16-5 (S)-trimethyl(4-methyl-1-phenoxypent-4-en-2-yloxy)silane 
• 1187921-85-2 C₁₂H₂₁NO₂Si 
• 681-99-2 tributyltin isocyanate 
• 5187-94-0 ampicillin trihydrate 
• 869290-30-2 C₁₄H₂₇NO₄Si₂ 
• 107-46-0 Hexamethyldisiloxane 
• 1118-02-1 trimethylsilyl isocyanate 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 182870-80-0 (C₆H₅)2PNHCONHP(C₆H₅)2 
• 18388-84-6 trimethylsilyloxy-nonane 
• 13871-89-1 trimethylsilyl cyclohexyl ether 
• 76734-92-4 Bis-trimethylsilylacetylenedicarboxylate 

Relevant articles and documents

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Catalysts for Silylations with 1,1,1,3,3,3-Hexamethyldisilazane

-