Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

1,4-Dichlorobenzene
Related Products

Hot Products

Basic Information Post buying leads Suppliers Cas Database
Name

1,4-Dichlorobenzene

 EINECS 203-400-5
CAS No. 106-46-7 Density 1.297 g/cm3
PSA 0.00000 LogP 2.99340
Solubility Insoluble in water Melting Point 52-54 °C(lit.)
Formula C6H4Cl2 Boiling Point 174.1 °C at 760 mmHg
Molecular Weight 147.004 Flash Point 60.7 °C
Transport Information UN 3077 9/PG 3 Appearance colourless or white crystal
Safety 36/37-46-60-61-45-16-7 Risk Codes 36-40-50/53-39/23/24/25-23/24/25-11
Molecular Structure Molecular Structure of 106-46-7 (1,4-Dichlorobenzene) Hazard Symbols HarmfulXn,DangerousN,ToxicT,FlammableF
Synonyms

1, 4-Dichlorobenzene;Paramoth;p-Dichloorbenzeen [Dutch];p-Diclorobenzene [Italian];p-Dichloorbenzeen;Dichlorobenzene, p-, solid;Benzene, p-dichloro-;1,4-Diclorobenzene [Italian];Paradichlorobenzol;Santochlor;RCRA waste no. D027;Paracide;1,4-Dichlor-benzol [German];RCRA waste no. U072;Globol;NCI-C54955;Di-chloricide;Para crystals;Paradow;RCRA waste number U070;p-Dichlorobenzol;1, 4-Dichloorbenzeen;Parazene;Persia-Perazol;benzene, 1,4-dichloro-;Benzene, 1, 4-dichloro-;Dichlorobenzene;4-Dichlorobenzene;p-Dichlorbenzol [German];RCRA waste number U071;PDCB;Paradi;Evola;p-Diclorobenzene;Paranuggets;1,4-Dichloorbenzeen [Dutch];p-Dichlorbenzol;1,4-Diclorobenzene;1,4-Dichlor-benzol;Paradichlorbenzol [German];

Article Data 249

1,4-Dichlorobenzene Synthetic route

637-87-6

1-Chloro-4-iodobenzene

106-46-7

para-dichlorobenzene

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; hypochlorite In dichloromethane other iodoaromatics, intermediacy of iodyl compounds at short reaction times;100%
With tetra(n-butyl)ammonium hydrogensulfate; hypochlorite In dichloromethane 23-28 h; Yield given;
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid
2: copper(l) chloride / acetonitrile / 2 h / 80 °C
View Scheme
95-94-3

1,2,4,5-tetrachlorobenzene

A

106-46-7

para-dichlorobenzene

B

95-50-1

1,2-dichloro-benzene

C

541-73-1

1,3-Dichlorobenzene

D

71-43-2

benzene

Conditions
ConditionsYield
With potassium hydroxide; hydrogen; palladium on activated charcoal In water at 50℃; for 0.92h; Yields of byproduct given;A n/a
B n/a
C n/a
D 98%
122-01-0

4-chloro-benzoyl chloride

106-46-7

para-dichlorobenzene

Conditions
ConditionsYield
palladium on activated charcoal In gas at 360℃;98%
106-39-8

bromochlorobenzene

106-46-7

para-dichlorobenzene

Conditions
ConditionsYield
With trans-bis(glycinato)copper(II) monohydrate; tetramethlyammonium chloride In ethanol at 100℃; for 24h; Finkelstein Reaction; Schlenk technique; Inert atmosphere;95%
With sodium hypochlorite; (tetraphenylporphyrinato)nickel(II); benzyl tri-n-butylammonium bromide In chloroform at 25℃; for 0.5h;75%
With tetrachloromethane; chlorine Photolysis;
With tetrachloromethane at 250℃; for 21h; Inert atmosphere; Autoclave;13 %Spectr.
With iron(III) chloride; sodium chloride In acetonitrile for 10h; Kinetics; Irradiation; Green chemistry; regioselective reaction;
98-60-2

4-chlorobenzenesulfonyl chloride

106-46-7

para-dichlorobenzene

Conditions
ConditionsYield
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile); hexamethylenetetramine at 54.9 - 64.9℃; for 2h; Thermodynamic data; Kinetics; Mechanism; activation energy;95%
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile); hexamethylenetetramine at 54.9 - 64.9℃;95%
120-82-1

1,2,4-Trichlorobenzene

A

106-46-7

para-dichlorobenzene

B

95-50-1

1,2-dichloro-benzene

C

541-73-1

1,3-Dichlorobenzene

Conditions
ConditionsYield
With radical anion of p,p'-di-tert-butylbiphenyl In tetrahydrofuran at -60℃; Product distribution; Rate constant; Mechanism; Irradiation; radical anion of naphthalene, different temperatures;A 87.2%
B 2.79%
C 9.96%
With radical anion of p,p'-di-tert-butylbiphenyl In tetrahydrofuran at -70℃; Irradiation;A 87.7%
B 2.97%
C 9.32%
With radical anion of p,p'-di-tert-butylbiphenyl In tetrahydrofuran at 45℃; Irradiation;A 75.3%
B 9.89%
C 13.7%

potassium (4-chlorophenyl)trifluoroborate

106-46-7

para-dichlorobenzene

Conditions
ConditionsYield
With trichloroisocyanuric acid In water; ethyl acetate at 20℃; for 1h; Open flask;86%
1204518-00-2

(4-chlorophenyl)(mesityl)iodonium trifluoromethanesulfonate

106-46-7

para-dichlorobenzene

Conditions
ConditionsYield
With copper(l) chloride In acetonitrile at 80℃; for 2h;83%
71-43-2

benzene

A

106-46-7

para-dichlorobenzene

B

108-90-7

chlorobenzene

C

95-50-1

1,2-dichloro-benzene

Conditions
ConditionsYield
With iron sulfide; antimony(III) sulfide; chlorine at 35 - 55℃; under 760.051 Torr; Reagent/catalyst; Temperature;A 7.2%
B 80.7%
C 3.1%
With hydrogenchloride; sodium peroxide In acetic acid at 78 - 80℃; for 3h;A 12%
B 79%
C 6%
With chlorine at 40 - 60℃; under 760.051 Torr; for 1.75h; Reagent/catalyst; Temperature;A 72.4%
B 5.1%
C 22%
106-47-8

4-chloro-aniline

106-46-7

para-dichlorobenzene

Conditions
ConditionsYield
With N-chloro-succinimide; sodium nitrite In N,N-dimethyl-formamide at 20℃; for 6h;80%
With tetrachloromethane; tert-Butyl thionitrate for 1h; Heating;40%
With tert.-butylnitrite; N-benzyl-N,N,N-triethylammonium chloride; copper dichloride; 10-camphorsulfonic acid In neat (no solvent) Time; Solvent;10%

1,4-Dichlorobenzene Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 192.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1974),p. 231.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 29 (1982),p. 213.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1974),p. 231.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program. Community Right-To-Know List.

1,4-Dichlorobenzene Standards and Recommendations

OSHA PEL: TWA 75 ppm; STEL 110 ppm
ACGIH TLV: TWA 10 ppm, Confirmed Animal Carcinogen.
DFG MAK: 50 ppm (300 mg/m3)
DOT Classification:  6.1; Label: KEEP AWAY FROM FOOD
NIOSH REL: (p-Dichlorobenzene): (1.7 ppm LOQ)

1,4-Dichlorobenzene Analytical Methods

For occupational chemical analysis use NIOSH: Hydrocarbons, Halogenated, 1003. 

1,4-Dichlorobenzene Specification

The 1,4-Dichlorobenzene is an organic compound with the formula C6H4Cl2. The IUPAC name of this chemical is 1,4-dichlorobenzene. With the CAS registry number 106-46-7, it is also named as Di-chloricide. The product's categories are Intermediates of Dyes and Pigments; Inorganic & Organic Chemicals; Organics; Analytical Chemistry; Standard Solution of Volatile Organic Compounds for Water & Soil Analysis; Standard Solutions (VOC); Alpha Sort; D; DAlphabetic; DIA - DICPesticides; Fumigants; Insecticides; Volatiles/ Semivolatiles; Pesticides & Metabolites; Aryl; C6; Halogenated Hydrocarbons; Alphabetic; DIA - DIC. Besides, it is a colourless or white crystal, which should be stored in a cool and well-ventilated place. It is used to control moths, moulds and mildew. It is used as a disinfectant in waste containers and restrooms and is the characteristic smell associated with urinal cakes.

Physical properties about 1,4-Dichlorobenzene are:
(1)ACD/LogP: 3.34; (2)ACD/LogD (pH 5.5): 3.34; (3)ACD/LogD (pH 7.4): 3.34; (4)ACD/BCF (pH 5.5): 201.98; (5)ACD/BCF (pH 7.4): 201.98; (6)ACD/KOC (pH 5.5): 1555.05; (7)ACD/KOC (pH 7.4): 1555.05; (8)Index of Refraction: 1.548; (9)Molar Refractivity: 36.04 cm3; (10)Molar Volume: 113.3 cm3; (11)Polarizability: 14.28×10-24cm3; (12)Surface Tension: 36.7 dyne/cm; (13)Density: 1.297 g/cm3; (14)Flash Point: 60.7 °C; (15)Enthalpy of Vaporization: 39.36 kJ/mol; (16)Boiling Point: 174.1 °C at 760 mmHg; (17)Vapour Pressure: 1.64 mmHg at 25°C.

Preparation of 1,4-Dichlorobenzene:
 this chemical is produced by chlorination of benzene using ferric chloride as a catalyst:
C6H6 + 2 Cl2 → C6H4Cl2 + 2 HCl

Uses of p-Dichlorobenzene:
 it can be used to produce 1,2,4,5-tetrabromo-3,6-dichloro-benzene. It will need reagent iron and bromine.


Safety informationg of 1,4-Dichlorobenzene:
When you are using this chemical, please be cautious about it as the following:It is highly flammable and very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. If swallowed, seek medical advice immediately and show this container or label. Please keep container tightly closed and keep away from sources of ignition - No smoking. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes. When you are using it, wear suitable protective clothing and gloves. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible). This material and its container must be disposed of as hazardous waste.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CC(=CC=C1Cl)Cl
(2)InChI: InChI=1S/C6H4Cl2/c7-5-1-2-6(8)4-3-5/h1-4H
(3)InChIKey: OCJBOOLMMGQPQU-UHFFFAOYSA-N

The toxicity data of 1,4-Dichlorobenzene is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LCLo inhalation 37gm/m3/30M (37000mg/m3) BEHAVIORAL: GENERAL ANESTHETIC Yakkyoku. Pharmacy. Vol. 38, Pg. 1045, 1987.
guinea pig LDLo oral 2800mg/kg (2800mg/kg)   AMA Archives of Industrial Health. Vol. 14, Pg. 138, 1956.
human LDLo oral 857mg/kg (857mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 210, 1969.
human LDLo unreported 357mg/kg (357mg/kg)   Yakkyoku. Pharmacy. Vol. 31, Pg. 1499, 1980.
human TDLo oral 300mg/kg (300mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 851, 1966.
mammal (species unspecified) LC50 inhalation 12gm/m3 (12000mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.
mammal (species unspecified) LD50 oral 2600mg/kg (2600mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.
man LDLo unreported 221mg/kg (221mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 intraperitoneal 2gm/kg (2000mg/kg)   Mutagenesis. Vol. 2, Pg. 111, 1987.
mouse LD50 oral 2950mg/kg (2950mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 183, 1973.
mouse LD50 subcutaneous 5145mg/kg (5145mg/kg) BEHAVIORAL: TREMOR Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 772, 1973.
rabbit LD50 oral 2830mg/kg (2830mg/kg)   Yakkyoku. Pharmacy. Vol. 29, Pg. 453, 1978.
rabbit LD50 skin > 2gm/kg (2000mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 18, 1978.
rat LD50 intraperitoneal 2562mg/kg (2562mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 124, 1949.
rat LD50 oral 500mg/kg (500mg/kg)   World Review of Pest Control. Vol. 9, Pg. 119, 1970.
rat LD50 skin > 6gm/kg (6000mg/kg)   Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 106-46-7