CAS No.106-47-8,4-Chloroaniline Suppliers

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Basic Information

Molecular Structure:
CAS No.:	106-47-8
Name:	4-Chloroaniline
Article Data:	770
Cas Database

Formula:	C₆H₆ClN
Molecular Weight:	127.573
Synonyms:	NSC 36941;p-Aminochlorobenzene;p-Chloroaniline;p-Chlorophenylamine;Aniline,p-chloro- (8CI);1-Amino-4-chlorobenzene;4-Amino-1-chlorobenzene;4-Aminochlorobenzene;4-Chloro-1-aminobenzene;4-Chlorobenzenamine;4-Chlorophenylamine;
EINECS:	203-401-0
Density:	1.23 g/cm³
Melting Point:	67-70 °C(lit.)
Boiling Point:	174.1 °C at 760 mmHg
Flash Point:	60.7 °C
Solubility:	soluble in hot water
Appearance:	Clear amber liquid
Hazard Symbols:	T，N，F
Risk Codes:	45-23/24/25-43-50/53-52/53-39/23/24/25-11
Safety:	53-45-60-61-36/37-16-7
Transport Information:	UN 2018 6.1/PG 2
PSA:	26.02000
LogP:	2.50340

Synthetic route

: 100-00-5
4-chlorobenzonitrile

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With sodium hydroxide; dodecacarbonyl-triangulo-triruthenium; 2-methoxy-ethanol; carbon monoxide; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 3h; Ambient temperature;	100%
With carbon monoxide; water; [Ru(cyclo-octa-1,5-diene)(pyridine)4][BPh4]2 In tetrahydrofuran at 170℃; for 20h;	100%
With copper(I) chloride; potassium borohydride In methanol for 0.25h; Ambient temperature;	100%

: 3296-05-7
1-azido-4-chlorobenzene

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With tetracarbonylhydridoferrate In ethanol for 12h; Ambient temperature;	100%
With sodium hydrogen telluride In diethyl ether; ethanol for 0.25h; Ambient temperature;	100%
With methyltriphenylphosphonium tetrahydroborate In dichloromethane for 3h; Reduction; Heating;	99%

: 539-03-7
N-(4-chlorophenyl)acetamide

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With 40% potassium fluoride/alumina at 85℃; for 0.0666667h; Microwave irradiation; Neat (no solvent);	99%
With ammonium bromide; ethylenediamine at 70℃; for 5h; Microwave irradiation; Inert atmosphere; neat (no solvent);	99%
Stage #1: N-(4-chlorophenyl)acetamide With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.05h; Inert atmosphere; Stage #2: With water In tetrahydrofuran Inert atmosphere;	92%

: 18437-66-6
N-(t-butoxycarbonyl)-4-chloroaniline

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With water at 100℃; for 10h;	99%
With Montmorillonite K10 In dichloromethane for 1.5h; deacylation; Heating;	98%
With H-β zeolite In dichloromethane for 5h; Heating;	98%

: 823-86-9
N-(4-chlorophenyl)hydroxylamine

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With hydrogen; sodium fluoride In methanol at 39.84℃; for 2.5h;	99%
With mackinawite; iron(II) at 23℃; pH=7.2; Kinetics; Further Variations:; Reagents;
With potassium borohydride; TPGS-750-M In water at 20℃; Inert atmosphere;	100 %Chromat.

: 100-00-5
4-chlorobenzonitrile

A: 106-47-8
4-chloro-aniline

B: 62-53-3
aniline

Conditions

Conditions	Yield
With hydrazine hydrate In toluene at 20℃; for 3h; Inert atmosphere;	A 95% B n/a
With hydrogen In ethyl acetate under 760.051 Torr; for 2h; Heating; Flow reactor; Green chemistry;	A 91% B 6%
With sodium tetrahydroborate In tetrahydrofuran; water at 25℃; for 1.5h;	A 90% B 10%

: 100-00-5
4-chlorobenzonitrile

12percent nickel/Al-SBA-15 fiber: 12percent nickel/Al-SBA-15 fiber

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With hydrogen In ethanol at 109.84℃; under 18751.9 Torr; for 7.5h; Autoclave; Green chemistry; chemoselective reaction;	95%

: 106-40-1
4-bromo-aniline

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With copper(I) oxide; tetramethlyammonium chloride; L-proline In ethanol at 110℃; for 15h; Inert atmosphere;	94%
With trans-bis(glycinato)copper(II) monohydrate; tetramethlyammonium chloride In ethanol at 100℃; for 12h; Finkelstein Reaction; Schlenk technique; Inert atmosphere;	92%
With iron(III) chloride; sodium chloride In acetonitrile for 10h; Inert atmosphere; Green chemistry; regioselective reaction;

: 288-32-4
1H-imidazole

: 123167-91-9
(4-Chloro-phenyl)-carbamic acid 10,10-dioxo-9,10-dihydro-10λ6-thioxanthen-9-ylmethyl ester

A: 123168-20-7
1-(10,10-Dioxo-9,10-dihydro-10λ6-thioxanthen-9-ylmethyl)-1H-imidazole

B: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
In dichloromethane for 4h; Ambient temperature;	A 93% B 46%

...Expand

: 106018-89-7
2-Trimethylsilanyl-ethanesulfonic acid (4-chloro-phenyl)-amide

: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 40h;	93%

Raw Materials

110-83-8

6831-82-9

932-98-9

3848-36-0

52234-21-6

719-59-5

873-77-8

953-14-0

Downstream Products

92-67-1

Total:112 Page 1 of 3 1 2 3 Next>>

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Chemistry

Product Name: 4-Chloroaniline (CAS NO.106-47-8)
IUPAC Name: 4-chloroaniline

MF: C₆H₆ClN
MW: 127.57
EINECS: 203-401-0
MP: 67-70 °C(lit.)
BP: 232 °C(lit.)
Density: 1,43 g/cm³
Vapor density: 4.4 (vs air)
Vapor pressure: 0.15 mm Hg ( 25 °C)
Refractive index: 1.5546
Fp: 120°C
Storage temp: 2-8°C
Water Solubility: 0.3 g/100 mL (20 °C)
Merck: 14,2118
BRN: 471359
Product Categories: Fluorobenzene; Anilines, Aromatic Amines and Nitro Compounds; 2002/61/EC; Alpha Sort; Aryl Amines MAK III, Category 2Volatiles/ Semivolatiles; C; CAlphabetic; CHMethod Specific; European Community: ISO and DIN; Method Specific; Oeko-Tex Standard 100; Amines; C2 to C6; Nitrogen Compounds; Aryl Amines MAK III, Category 2Pesticides&Metabolites; Aryl Amines MAK III, Category 2Alphabetic; ChloroMore...Close...;Analytical Standards; AromaticsChemical Class; AromaticsMethod Specific; CHChemical Class; Chemical Class; Halogenated

Uses

4-Chloroaniline (CAS NO.106-47-8) is mainly used as dye int, pharmaceuticals and agricultural chemicals.

Toxicity Data With Reference

1.	skn-rbt 500 mg/24H MLD	28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,96.
2.	eye-rbt 250 µg/24H SEV	28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,96.
3.	mma-sat 100 µg/plate	ENMUDM Environmental Mutagenesis. 7 (Suppl 5)(1985),1.
4.	otr-rat:emb 14,500 ng/plate	JJATDK JAT, Journal of Applied Toxicology. 1 (1981),190.
5.	dns-rat:lvr 5 mg/L	MUREAV Mutation Research. 97 (1982),359.
6.	orl-rat TDLo:9270 mg/kg/2Y-C:CAR	FCTOD7 Food and Chemical Toxicology. 29 (1991),119.
7.	orl-rat LD50:310 mg/kg	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.

Consensus Reports

EPA Genetic Toxicology Program. 4-Chloroaniline (CAS NO.106-47-8) is reported in EPA TSCA Inventory.

Safety Profile

Safety Information of 4-Chloroaniline (CAS NO.106-47-8):
Hazard Codes: T Toxic ,N Dangerous ,F Flammable
RIDADR: UN 2018 6.1/PG 2
WGK Germany: 3
RTECS: BX0700000
Hazard Note: Toxic/Possible Carcinogen
HazardClass: 6.1
PackingGroup: II
HS Code: 29214210
Hazardous Substances Data: 106-47-8(Hazardous Substances Data)
Confirmed carcinogen with experimental neoplastigenic and tumorigenic data. Poison by ingestion, inhalation, skin contact, subcutaneous, and intravenous routes. A skin and severe eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x.

Standards and Recommendations

DFG MAK: Animal Carcinogen, Suspected Human Carcinogen