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| CAS No.: | 106-47-8 |
|---|---|
| Name: | 4-Chloroaniline |
| Article Data: | 770 |
| Molecular Structure: | |
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| Formula: | C6H6ClN |
| Molecular Weight: | 127.573 |
| Synonyms: | NSC 36941;p-Aminochlorobenzene;p-Chloroaniline;p-Chlorophenylamine;Aniline,p-chloro- (8CI);1-Amino-4-chlorobenzene;4-Amino-1-chlorobenzene;4-Aminochlorobenzene;4-Chloro-1-aminobenzene;4-Chlorobenzenamine;4-Chlorophenylamine; |
| EINECS: | 203-401-0 |
| Density: | 1.23 g/cm3 |
| Melting Point: | 67-70 °C(lit.) |
| Boiling Point: | 174.1 °C at 760 mmHg |
| Flash Point: | 60.7 °C |
| Solubility: | soluble in hot water |
| Appearance: | Clear amber liquid |
| Hazard Symbols: |
 T， N， F
|
| Risk Codes: | 45-23/24/25-43-50/53-52/53-39/23/24/25-11 |
| Safety: | 53-45-60-61-36/37-16-7 |
| Transport Information: | UN 2018 6.1/PG 2 |
| PSA: | 26.02000 |
| LogP: | 2.50340 |
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| Conditions | Yield |
|---|---|
| With sodium hydroxide; dodecacarbonyl-triangulo-triruthenium; 2-methoxy-ethanol; carbon monoxide; N-benzyl-N,N,N-triethylammonium chloride In benzene under 760 Torr; for 3h; Ambient temperature; | 100% |
| With carbon monoxide; water; [Ru(cyclo-octa-1,5-diene)(pyridine)4][BPh4]2 In tetrahydrofuran at 170℃; for 20h; | 100% |
| With copper(I) chloride; potassium borohydride In methanol for 0.25h; Ambient temperature; | 100% |
| Conditions | Yield |
|---|---|
| With tetracarbonylhydridoferrate In ethanol for 12h; Ambient temperature; | 100% |
| With sodium hydrogen telluride In diethyl ether; ethanol for 0.25h; Ambient temperature; | 100% |
| With methyltriphenylphosphonium tetrahydroborate In dichloromethane for 3h; Reduction; Heating; | 99% |
| Conditions | Yield |
|---|---|
| With 40% potassium fluoride/alumina at 85℃; for 0.0666667h; Microwave irradiation; Neat (no solvent); | 99% |
| With ammonium bromide; ethylenediamine at 70℃; for 5h; Microwave irradiation; Inert atmosphere; neat (no solvent); | 99% |
| Stage #1: N-(4-chlorophenyl)acetamide With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.05h; Inert atmosphere; Stage #2: With water In tetrahydrofuran Inert atmosphere; | 92% |
- 18437-66-6
N-(t-butoxycarbonyl)-4-chloroaniline
- 106-47-8
4-chloro-aniline
| Conditions | Yield |
|---|---|
| With water at 100℃; for 10h; | 99% |
| With Montmorillonite K10 In dichloromethane for 1.5h; deacylation; Heating; | 98% |
| With H-β zeolite In dichloromethane for 5h; Heating; | 98% |
| Conditions | Yield |
|---|---|
| With hydrogen; sodium fluoride In methanol at 39.84℃; for 2.5h; | 99% |
| With mackinawite; iron(II) at 23℃; pH=7.2; Kinetics; Further Variations:; Reagents; | |
| With potassium borohydride; TPGS-750-M In water at 20℃; Inert atmosphere; | 100 %Chromat. |
| Conditions | Yield |
|---|---|
| With hydrazine hydrate In toluene at 20℃; for 3h; Inert atmosphere; | A 95% B n/a |
| With hydrogen In ethyl acetate under 760.051 Torr; for 2h; Heating; Flow reactor; Green chemistry; | A 91% B 6% |
| With sodium tetrahydroborate In tetrahydrofuran; water at 25℃; for 1.5h; | A 90% B 10% |
| Conditions | Yield |
|---|---|
| With hydrogen In ethanol at 109.84℃; under 18751.9 Torr; for 7.5h; Autoclave; Green chemistry; chemoselective reaction; | 95% |
| Conditions | Yield |
|---|---|
| With copper(I) oxide; tetramethlyammonium chloride; L-proline In ethanol at 110℃; for 15h; Inert atmosphere; | 94% |
| With trans-bis(glycinato)copper(II) monohydrate; tetramethlyammonium chloride In ethanol at 100℃; for 12h; Finkelstein Reaction; Schlenk technique; Inert atmosphere; | 92% |
| With iron(III) chloride; sodium chloride In acetonitrile for 10h; Inert atmosphere; Green chemistry; regioselective reaction; |
- 288-32-4
1H-imidazole
- 123167-91-9
(4-Chloro-phenyl)-carbamic acid 10,10-dioxo-9,10-dihydro-10λ6-thioxanthen-9-ylmethyl ester
A
- 123168-20-7
1-(10,10-Dioxo-9,10-dihydro-10λ6-thioxanthen-9-ylmethyl)-1H-imidazole
B
- 106-47-8
4-chloro-aniline
| Conditions | Yield |
|---|---|
| In dichloromethane for 4h; Ambient temperature; | A 93% B 46% |
- 106018-89-7
2-Trimethylsilanyl-ethanesulfonic acid (4-chloro-phenyl)-amide
- 106-47-8
4-chloro-aniline
| Conditions | Yield |
|---|---|
| With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 40h; | 93% |
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- Total:36 Page 1 of 1 1
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Chemistry
Product Name: 4-Chloroaniline (CAS NO.106-47-8)
IUPAC Name: 4-chloroaniline
MF: C6H6ClN
MW: 127.57
EINECS: 203-401-0
MP: 67-70 °C(lit.)
BP: 232 °C(lit.)
Density: 1,43 g/cm3
Vapor density: 4.4 (vs air)
Vapor pressure: 0.15 mm Hg ( 25 °C)
Refractive index: 1.5546
Fp: 120°C
Storage temp: 2-8°C
Water Solubility: 0.3 g/100 mL (20 °C)
Merck: 14,2118
BRN: 471359
Product Categories: Fluorobenzene; Anilines, Aromatic Amines and Nitro Compounds; 2002/61/EC; Alpha Sort; Aryl Amines MAK III, Category 2Volatiles/ Semivolatiles; C; CAlphabetic; CHMethod Specific; European Community: ISO and DIN; Method Specific; Oeko-Tex Standard 100; Amines; C2 to C6; Nitrogen Compounds; Aryl Amines MAK III, Category 2Pesticides&Metabolites; Aryl Amines MAK III, Category 2Alphabetic; ChloroMore...Close...;Analytical Standards; AromaticsChemical Class; AromaticsMethod Specific; CHChemical Class; Chemical Class; Halogenated
Uses
4-Chloroaniline (CAS NO.106-47-8) is mainly used as dye int, pharmaceuticals and agricultural chemicals.
Toxicity Data With Reference
| 1. | skn-rbt 500 mg/24H MLD | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,96. | ||
| 2. | eye-rbt 250 µg/24H SEV | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,96. | ||
| 3. | mma-sat 100 µg/plate | ENMUDM Environmental Mutagenesis. 7 (Suppl 5)(1985),1. | ||
| 4. | otr-rat:emb 14,500 ng/plate | JJATDK JAT, Journal of Applied Toxicology. 1 (1981),190. | ||
| 5. | dns-rat:lvr 5 mg/L | MUREAV Mutation Research. 97 (1982),359. | ||
| 6. | orl-rat TDLo:9270 mg/kg/2Y-C:CAR | FCTOD7 Food and Chemical Toxicology. 29 (1991),119. | ||
| 7. | orl-rat LD50:310 mg/kg | AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95. | ||
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Consensus Reports
EPA Genetic Toxicology Program. 4-Chloroaniline (CAS NO.106-47-8) is reported in EPA TSCA Inventory.
Safety Profile
Safety Information of 4-Chloroaniline (CAS NO.106-47-8):
Hazard Codes: T
,N
,F
RIDADR: UN 2018 6.1/PG 2
WGK Germany: 3
RTECS: BX0700000
Hazard Note: Toxic/Possible Carcinogen
HazardClass: 6.1
PackingGroup: II
HS Code: 29214210
Hazardous Substances Data: 106-47-8(Hazardous Substances Data)
Confirmed carcinogen with experimental neoplastigenic and tumorigenic data. Poison by ingestion, inhalation, skin contact, subcutaneous, and intravenous routes. A skin and severe eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl− and NOx.
Standards and Recommendations
DFG MAK: Animal Carcinogen, Suspected Human Carcinogen