- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- 1-methyl-4-phenyl-1,2,3,6-tetrahydroxpyridine
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Cas Database |
| Name |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride |
EINECS | N/A |
| CAS No. | 23007-85-4 | Density | g/cm3 |
| PSA | 3.24000 | LogP | 3.14540 |
| Solubility | N/A | Melting Point |
249.0 to 254.0 °C |
| Formula | C12H15 N . Cl H | Boiling Point | 258.6°Cat760mmHg |
| Molecular Weight | 209.719 | Flash Point | 105.8°C |
| Transport Information | UN 2811 | Appearance | N/A |
| Safety | A poison by intraperitoneal and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and Cl−. | Risk Codes | R25;R39/23/24/25 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride (8CI,9CI); 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinehydrochloride |
Article Data | 1 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Synthetic route
- 1445-73-4
1-Methyl-4-piperidone
- 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: dibutyl ether; tetrahydrofuran / -78 - 20 °C 2: hydrogenchloride / water / 5 h / Reflux View Scheme |
- 591-51-5
phenyllithium
- 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: dibutyl ether; tetrahydrofuran / -78 - 20 °C 2: hydrogenchloride / water / 5 h / Reflux View Scheme |
- 4972-68-3
1-methyl-4-phenyl-piperidin-4-ol
- 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water for 5h; Reflux; |
- 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- 95969-40-7
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide
| Conditions | Yield |
|---|---|
| Stage #1: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride With sodium ethanolate In ethanol at 0℃; Stage #2: With dihydrogen peroxide In ethanol; water at 50℃; | 100% |
- 23007-85-4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- 207395-42-4
1-(N-formyl-N-methyl)amino-3-phenylpropan-2-one
| Conditions | Yield |
|---|---|
| With potassium permanganate In acetone at 20℃; for 2h; | 85% |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemical Properties
IUPAC Name: 1-Methyl-4-phenyl-3,6-dihydro-2H-pyridine hydrochloride
Synonyms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinium chloride ; 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine hydrochloride ; Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride (1:1) ; Pyridine, 1,2,5,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride
Product Categories: Heterocyclic Compounds;Neurochemicals
CAS NO:23007-85-4
Molecular Formula of 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride (CAS NO.23007-85-4) :C12H16ClN
Molecular Weight of 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride (CAS NO.23007-85-4) : 209.72
Molecular structure of 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride (CAS NO.23007-85-4) : 
Flash Point: 105.8 °C
Enthalpy of Vaporization: 49.62 kJ/mol
Boiling Point: 258.6 °C at 760 mmHg
Vapour Pressure: 0.0136 mmHg at 25°C
Appearance:White Solid
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Uses
1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridine hydrochloride (CAS NO.23007-85-4) is used as a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 150mg/kg (150mg/kg) | Annales Pharmaceutiques Francaises. Vol. 12, Pg. 241, 1954. | |
| mouse | LD50 | subcutaneous | 53800ug/kg (53.8mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 247, Pg. 531, 1988. |
| rat | LD50 | intraperitoneal | 72mg/kg (72mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Bulletin of Experimental Biology and Medicine Vol. 105, Pg. 470, 1988. |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Safety Profile
A poison by intraperitoneal and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and Cl−.
Hazard Codes 
T
Risk Statements 39-23/24/25
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R39:Danger of very serious irreversible effects.
Safety Statements 45
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR 2811
RTECS UT8358950
HazardClass 6.1(b)
PackingGroup III
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