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2,4-Dinitrophenylhydrazine

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Name

2,4-Dinitrophenylhydrazine

EINECS 204-309-3
CAS No. 119-26-6 Density 1.655 g/cm3
PSA 129.69000 LogP 2.60830
Solubility slightly soluble in water Melting Point 197-200 °C(lit.)
Formula C6H6N4O4 Boiling Point 378.603 °C at 760 mmHg
Molecular Weight 198.138 Flash Point 182.773 °C
Transport Information UN 3380 4.1/PG 1 Appearance white to light yellow crystal powder
Safety 35-48A-45-36/37-16 Risk Codes 1-11-22-40
Molecular Structure Molecular Structure of 119-26-6 (2,4-Dinitrophenylhydrazine) Hazard Symbols FlammableF, HarmfulXn
Synonyms

2,4-dinitro-3,5,6-trideuterophenylhydrazine;2,4-dinitrophenylhydrazine

Article Data 43

2,4-Dinitrophenylhydrazine Synthetic route

97-00-7

1-chloro-2,4-dinitro-benzene

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With pyrographite; hydrazine hydrate In ethanol for 1.16667h; Time; Reflux;100%
With hydrazine hydrate In ethanol for 3.5h; Reflux;91%
With ammonium hydroxide; hydrazine hydrate
100-63-0

phenylhydrazine

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With bismuth (III) nitrate pentahydrate; palladium diacetate In 2,2,2-trifluoroethanol; trifluoroacetic acid at 20 - 90℃; for 24h; Inert atmosphere;69%
610-54-8

2,4-dinitro-1-ethoxybenzene

A

136-79-8

2-Amino-4-nitroethoxybenzen

B

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With nickel; hydrazine hydrate In ethanol; 1,2-dichloro-ethane at 50 - 60℃; for 4h;A 6%
B n/a
2831-60-9

2-(2,4-dinitrophenoxy)ethanol

A

59820-37-0

2-(2-amino-4-nitro-phenoxy)-ethanol

B

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With nickel; hydrazine hydrate In ethanol; 1,2-dichloro-ethane at 50 - 60℃; for 4h;A 1%
B n/a
10242-16-7

2,4-dinitrophenyl isopropyl ether

A

53965-13-2

2-isopropoxy-5-nitro-aniline

B

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With nickel; hydrazine hydrate In ethanol; 1,2-dichloro-ethane at 50 - 60℃; for 4h;A 1%
B n/a
67674-33-3

2,4-dinitrophenyl 2-methoxyethyl ether

A

63810-54-8

2-(2-methoxy-ethoxy)-5-nitro-aniline

B

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With nickel; hydrazine hydrate In ethanol; 1,2-dichloro-ethane at 50 - 60℃; for 4h;A 1%
B n/a
40742-19-6

3-(2,4-dinitro-phenoxy)-propane-1,2-diol

A

88964-89-0

3-(2-amino-4-nitro-phenoxy)-propane-1,2-diol

B

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With nickel; hydrazine hydrate In ethanol; 1,2-dichloro-ethane at 50 - 60℃; for 3h;A 1%
B n/a
2486-07-9

2,4-dinitrophenyl phenyl ether

A

5410-98-0

5-nitro-2-phenoxy-aniline

B

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With nickel; hydrazine hydrate In ethanol; 1,2-dichloro-ethane at 50 - 60℃; for 3h;A 0.5%
B n/a
584-48-5

2,4-dinitrobromobenzene

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With ethanol; hydrazine hydrate
119-27-7

2,4-dinitroanisole

119-26-6

(2,4-dinitro-phenyl)-hydrazine

Conditions
ConditionsYield
With ethanol; hydrazine hydrate
With ethanol; hydrazine hydrate; acetic acid

2,4-Dinitrophenylhydrazine Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

2,4-Dinitrophenylhydrazine Specification

The 2,4-Dinitrophenylhydrazine, with the CAS registry number 119-26-6, is also known as 1-Hydrazino-2,4-dinitrobenzene.It belongs to the product Chemical Reagent.Its EINECS number is 204-309-3. This chemical's molecular formula is C6H6N4O4 and molecular weight is 198.13. What's more,Its systematic name is (2,4-Dinitrophenyl)hydrazine.And it is Used for determination of serum transaminase valley - and c - grass substrate supporting reagents.

Physical properties about 2,4-Dinitrophenylhydrazine are:(1)ACD/LogP: 1.454; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.45; (4)ACD/LogD (pH 7.4): 1.45; (5)ACD/BCF (pH 5.5): 7.50; (6)ACD/BCF (pH 7.4): 7.50; (7)ACD/KOC (pH 5.5): 147.21; (8)ACD/KOC (pH 7.4): 147.29; (9)#Freely Rotating Bonds: 4 ; (10)Index of Refraction: 1.731; (11)Molar Refractivity: 47.856 cm3; (12)Molar Volume: 119.744 cm3; (13)Surface Tension: 87.6439971923828 dyne/cm; (14)Density: 1.655 g/cm3; (15)Flash Point: 182.773 °C; (16)Enthalpy of Vaporization: 62.652 kJ/mol; (17)Boiling Point: 378.603 °C at 760 mmHg; (18)Vapour Pressure: 0 mmHg at 25°C.

Preparation: 2,4-Dinitrophenylhydrazine can be prepared by hydrazine sulfate and 2,4-dinitrochlorobenzene.

The 2,4-Dinitrophenylhydrazine is Highly Flammable,Harmful. When you are using it, please be cautious about it as the following: (1)Explosive when dry; (2)Highly Flammable; (3)Harmful if swallowed; (4)Limited evidence of a carcinogenic effect; (5)This material and its container must be disposed of in a safe way; (6)In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); (7)Wear suitable protective clothing; (8)Wear suitable gloves; (9)Keep away from sources of ignition-No smoking.

You can still convert the following datas into molecular structure:
(1)SMILES:c1cc(c(cc1[N+](=O)[O-])[N+](=O)[O-])NN;
(2)Std. InChI:InChI=1S/C6H6N4O4/c7-8-5-2-1-4(9(11)12)3-6(5)10(13)14/h1-3,8H,7H2;
(3)Std. InChIKey:HORQAOAYAYGIBM-UHFFFAOYSA-N.

The toxicity data of 2,4-Dinitrophenylhydrazine as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 450mg/kg (450mg/kg)   Cancer Research. Vol. 41, Pg. 1469, 1981.
rat LD oral > 500mg/kg (500mg/kg)   National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 25, 1953.

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