- 1004-00-8Benzenethiol,2-amino-4-chloro-
- 100402-39-9Aluminum zirconium bromide
- 100402-45-7Aluminum,2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)-1,2-dihydro-6,8-quinolinedisulfonatecomplexes
- 100402-53-7Cadmium chloridephosphate (Cd5Cl(PO4)3), manganese-doped
- 100402-75-3calcium; dihydroxy-oxo-silane; 3-triethoxysilylpropan-1-amine
- 100-40-3Cyclohexene, 4-ethenyl-
- 100403-10-9Titanate(4-),oxobis[phosphato(3-)]-, barium (1:2), uranium-doped
- 100403-11-0Vanadiumyttrium oxide phosphate, dysprosium and europium-doped
- 100403-19-8Ceramides
- 100403-24-5Deoxyribonucleic acids,fish sperm
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
2-Bromo-5-fluoroaniline |
EINECS | N/A |
| CAS No. | 1003-99-2 | Density | 1.694 g/cm3 |
| PSA | 26.02000 | LogP | 2.75160 |
| Solubility | N/A | Melting Point |
43-47 °C(lit.) |
| Formula | C6H5BrFN | Boiling Point | 228.2 °C at 760 mmHg |
| Molecular Weight | 190.015 | Flash Point | 91.8 °C |
| Transport Information | UN 2811 | Appearance | yellow to brown crystalline powder |
| Safety | 26-36 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi, T
|
| Synonyms |
2-Bromo-5-fluoro-phenylamine;2-bromo-5-fluoro-aniline;2-Bromo-fluoroaniline;2-bromo-5-fluorobenzenamine;2-fluoro-5-bromoaniline; |
Article Data | 18 |
2-Bromo-5-fluoroaniline Synthetic route
| Conditions | Yield |
|---|---|
| Stage #1: 2-bromo-5-fluoronitrobenzene With iron; acetic acid In ethanol at 20℃; for 2.08333h; Heating / reflux; Stage #2: With sodium hydroxide In diethyl ether; water | 100% |
| With tin(ll) chloride In ethanol at 50℃; for 2h; Reagent/catalyst; Temperature; | 100% |
| With iron; acetic acid In ethanol; water at 80 - 85℃; for 6h; | 98.9% |
- 909274-50-6
2-azido-1-bromo-5-fluorobenzene
- 1003-99-2
2-bromo-5-fluoroaniline
| Conditions | Yield |
|---|---|
| With iron(III) oxide; hydrazine hydrate In water at 120℃; for 2.5h; Inert atmosphere; | 81% |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: HCl; aq. NaNO2 / 0 °C 1.2: CuBr; HCl / 0 - 60 °C 2.1: H2 / Raney Ni View Scheme |
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide In DCE at 20℃; | A 11 %Chromat. B 89 %Chromat. |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / water / 0.25 h / 0 °C 2: ammonium chloride; zinc / water / 0.5 h / 80 °C View Scheme |
| Conditions | Yield |
|---|---|
| With hydrogen bromide; dimethyl sulfoxide In ethyl acetate at 60℃; for 12h; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: toluene / 2 h / 5 - 25 °C / Large scale 2.1: sulfuric acid / dichloromethane / 1 h / 0 - 5 °C 2.2: 1 h / 5 - 10 °C 3.1: sulfuric acid / water / 14 h / 75 - 80 °C 3.2: 1 h / 0 - 5 °C 3.3: 2 h / 40 - 50 °C 4.1: iron; acetic acid / water; ethanol / 6 h / 80 - 85 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: sulfuric acid / dichloromethane / 1 h / 0 - 5 °C 1.2: 1 h / 5 - 10 °C 2.1: sulfuric acid / water / 14 h / 75 - 80 °C 2.2: 1 h / 0 - 5 °C 2.3: 2 h / 40 - 50 °C 3.1: iron; acetic acid / water; ethanol / 6 h / 80 - 85 °C View Scheme |
- 696-59-3
cis,trans-2,5-dimethoxytetrahydrofuran
- 1003-99-2
2-bromo-5-fluoroaniline
- 1254221-18-5
1-(2-bromo-5-fluorophenyl)-1H-pyrrole
| Conditions | Yield |
|---|---|
| With water; acetic acid In 1,2-dichloro-ethane at 80℃; Paal-Knorr pyrrole synthesis; Inert atmosphere; | 100% |
| With acetic acid for 1h; Reflux; |
- 1003-99-2
2-bromo-5-fluoroaniline
- 3282-30-2
pivaloyl chloride
- 885609-84-7
N-(2-bromo-5-fluorophenyl)pivalamide
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; | 98% |
| With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h; | 98% |
| With triethylamine In dichloromethane at 0 - 20℃; for 3h; | 92% |
| With triethylamine In dichloromethane at 0 - 30℃; | |
| With triethylamine In dichloromethane at 0 - 20℃; |
2-Bromo-5-fluoroaniline Chemical Properties
The molecular structure of 2-Bromo-5-fluoroaniline (CAS NO.1003-99-2):
IUPAC Name: 2-Bromo-5-fluoroaniline
Molecular Weight: 190.013003 g/mol
Molecular Formula: C6H5BrFN
Density: 1.694 g/cm3
Melting Point: 43-47 °C(lit.)
Boiling Point: 228.2 °C at 760 mmHg
Flash Point: 91.8 °C
Index of Refraction: 1.596
Molar Refractivity: 38.17 cm3
Molar Volume: 112.1 cm3
Surface Tension: 45.2 dyne/cm
Enthalpy of Vaporization: 46.48 kJ/mol
Vapour Pressure: 0.0743 mmHg at 25 °C
XLogP3-AA: 2
H-Bond Donor: 1
H-Bond Acceptor: 2
Exact Mass: 188.95894
MonoIsotopic Mass: 188.95894
Topological Polar Surface Area: 26
Heavy Atom Count: 9
Canonical SMILES: C1=CC(=C(C=C1F)N)Br
InChI: InChI=1S/C6H5BrFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2
InChIKey: FWTXFEKVHSFTDQ-UHFFFAOYSA-N
Product Categories: Aniline; Anilines, Amides & Amines; Bromine Compounds; Fluorine Compounds; Pharmaceutical intermediate; Amines; C2 to C6; Nitrogen Compounds
2-Bromo-5-fluoroaniline Safety Profile
Hazard Codes: 
Xi, 
T
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
2-Bromo-5-fluoroaniline Specification
2-Bromo-5-fluoroaniline (CAS NO.1003-99-2) is also named as 2-Brom-5-fluoranilin ; benzenamine, 2-bromo-5-fluoro- ; 2-Bromo-4-fluoroaniline ; 2-Bromo-5-fluoroaniline 98% . 2-Bromo-5-fluoroaniline (CAS NO.1003-99-2) is yellow to brown crystalline powder.
What can I do for you?
Get Best Price
