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Name |
2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid |
EINECS | N/A |
CAS No. | 218600-44-3 | Density | 1.18g/cm3 |
PSA | 95.23000 | LogP | 6.29058 |
Solubility | N/A | Melting Point |
180-182 °C |
Formula | C31H41NO4 | Boiling Point | 632.9°Cat760mmHg |
Molecular Weight | 491.671 | Flash Point | 336.6°C |
Transport Information | N/A | Appearance | N/A |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
(4aS,6aR,6bS,8aS,12aR,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid; |
Article Data | 8 |
bardoxolone methyl
bardoxolone
Conditions | Yield |
---|---|
With lithium iodide In N,N-dimethyl-formamide | 71% |
With lithium iodide In N,N-dimethyl-formamide | 71% |
With lithium iodide In N,N-dimethyl-formamide at 153℃; for 12h; Inert atmosphere; | 70.3% |
With lithium iodide In N,N-dimethyl-formamide for 4h; Heating; | 68% |
With lithium iodide In N,N-dimethyl-formamide Inert atmosphere; Reflux; | 44% |
tert‐butyl N‐[2‐(N‐hydroxycarbamimidoyl)ethyl]carbamate
2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid chloride
B
bardoxolone
Conditions | Yield |
---|---|
Stage #1: tert‐butyl N‐[2‐(N‐hydroxycarbamimidoyl)ethyl]carbamate; 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid chloride With triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere; Stage #2: With tetra(n-butyl)ammonium hydroxide In tetrahydrofuran; water at 20℃; for 5h; Inert atmosphere; | A 45% B n/a |
tert‐butyl N‐[2‐(N‐hydroxycarbamimidoyl)ethyl]carbamate
2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid chloride
B
bardoxolone
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere; |
3-methoxypropionamidoxime hydrochloride
2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid chloride
B
bardoxolone
Conditions | Yield |
---|---|
With triethylamine; trimethylamine In dichloromethane at 20℃; Inert atmosphere; |
methyl 3β-acetoxy-12-oxoolean-9(11)-en-28-oate
bardoxolone
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 97 percent / methanolic KOH / 0.5 h / Heating 2: 92 percent / Jones reagent / acetone / 0.17 h / 20 °C 3: 99 percent / NaOMe / benzene / 2 h / 20 °C 4: 66 percent / NH2OH*HCl / ethanol; H2O / 1 h / Heating 5: 100 percent / NaOMe / methanol; diethyl ether / 0.75 h / 20 °C 6: 92 percent / DDQ / benzene / 0.5 h / Heating 7: 68 percent / LiI / dimethylformamide / 4 h / Heating View Scheme | |
Multi-step reaction with 7 steps 1: aq. KOH / methanol 2: CrO3, H2SO4 3: 100 percent / sodium methoxide / benzene 4: 61 percent / NH2OH*HCl / aq. ethanol 5: 100 percent / sodium methoxide / methanol; diethyl ether 6: 1.) phenylselenenyl chloride, 2.) 30 percent aq. H2O2 / 1.) ethyl acetate, 2.) THF 7: 71 percent / LiI / dimethylformamide View Scheme | |
Multi-step reaction with 6 steps 1: potassium hydroxide; water / methanol 2: sodium methylate / benzene 3: hydroxylamine hydrochloride / water; ethanol 4: sodium methylate / methanol; diethyl ether 5: Phenylselenyl chloride / ethyl acetate 6: lithium iodide / N,N-dimethyl-formamide View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium hydroxide / methanol / 1 h / Reflux 2.1: chromium(VI) oxide; sulfuric acid / water; acetone / 0 - 20 °C 3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.33 h / -78 - 20 °C / Inert atmosphere 3.2: 0.08 h / -78 - 20 °C 4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 0.5 h / Reflux; Inert atmosphere 5.1: lithium iodide / N,N-dimethyl-formamide / Inert atmosphere; Reflux View Scheme |
methyl 3,12-dioxoolean-9(11)-en-28-oate
bardoxolone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 99 percent / NaOMe / benzene / 2 h / 20 °C 2: 66 percent / NH2OH*HCl / ethanol; H2O / 1 h / Heating 3: 100 percent / NaOMe / methanol; diethyl ether / 0.75 h / 20 °C 4: 92 percent / DDQ / benzene / 0.5 h / Heating 5: 68 percent / LiI / dimethylformamide / 4 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1: 100 percent / sodium methoxide / benzene 2: 61 percent / NH2OH*HCl / aq. ethanol 3: 100 percent / sodium methoxide / methanol; diethyl ether 4: 1.) phenylselenenyl chloride, 2.) 30 percent aq. H2O2 / 1.) ethyl acetate, 2.) THF 5: 71 percent / LiI / dimethylformamide View Scheme | |
Multi-step reaction with 5 steps 1: sodium methylate / benzene 2: hydroxylamine hydrochloride / water; ethanol 3: sodium methylate / methanol; diethyl ether 4: Phenylselenyl chloride / ethyl acetate 5: lithium iodide / N,N-dimethyl-formamide View Scheme | |
Multi-step reaction with 3 steps 1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.33 h / -78 - 20 °C / Inert atmosphere 1.2: 0.08 h / -78 - 20 °C 2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 0.5 h / Reflux; Inert atmosphere 3.1: lithium iodide / N,N-dimethyl-formamide / Inert atmosphere; Reflux View Scheme |
methyl 3β-hydroxy-12-oxoolean-9(11)-en-28-oate
bardoxolone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 92 percent / Jones reagent / acetone / 0.17 h / 20 °C 2: 99 percent / NaOMe / benzene / 2 h / 20 °C 3: 66 percent / NH2OH*HCl / ethanol; H2O / 1 h / Heating 4: 100 percent / NaOMe / methanol; diethyl ether / 0.75 h / 20 °C 5: 92 percent / DDQ / benzene / 0.5 h / Heating 6: 68 percent / LiI / dimethylformamide / 4 h / Heating View Scheme | |
Multi-step reaction with 6 steps 1: CrO3, H2SO4 2: 100 percent / sodium methoxide / benzene 3: 61 percent / NH2OH*HCl / aq. ethanol 4: 100 percent / sodium methoxide / methanol; diethyl ether 5: 1.) phenylselenenyl chloride, 2.) 30 percent aq. H2O2 / 1.) ethyl acetate, 2.) THF 6: 71 percent / LiI / dimethylformamide View Scheme | |
Multi-step reaction with 4 steps 1.1: chromium(VI) oxide; sulfuric acid / water; acetone / 0 - 20 °C 2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.33 h / -78 - 20 °C / Inert atmosphere 2.2: 0.08 h / -78 - 20 °C 3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 0.5 h / Reflux; Inert atmosphere 4.1: lithium iodide / N,N-dimethyl-formamide / Inert atmosphere; Reflux View Scheme |
methyl 12-oxoisoxazolo[4,5-b]olean-9(11)-en-28-oate
bardoxolone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / NaOMe / methanol; diethyl ether / 0.75 h / 20 °C 2: 92 percent / DDQ / benzene / 0.5 h / Heating 3: 68 percent / LiI / dimethylformamide / 4 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 100 percent / sodium methoxide / methanol; diethyl ether 2: 1.) phenylselenenyl chloride, 2.) 30 percent aq. H2O2 / 1.) ethyl acetate, 2.) THF 3: 71 percent / LiI / dimethylformamide View Scheme | |
Multi-step reaction with 3 steps 1: sodium methylate / methanol; diethyl ether 2: Phenylselenyl chloride / ethyl acetate 3: lithium iodide / N,N-dimethyl-formamide View Scheme |
2-cyano-3-hydroxy-12-oxoolean-2(3),9(11)-dien-28-oic acid
bardoxolone
Conditions | Yield |
---|---|
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene for 0.25h; Reflux; | 91% |
methyl 2-hydroxymethylene-3,12-dioxoolean-9(11)-en-28-oate
bardoxolone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 66 percent / NH2OH*HCl / ethanol; H2O / 1 h / Heating 2: 100 percent / NaOMe / methanol; diethyl ether / 0.75 h / 20 °C 3: 92 percent / DDQ / benzene / 0.5 h / Heating 4: 68 percent / LiI / dimethylformamide / 4 h / Heating View Scheme |
The 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid with the cas number 218600-44-3 is also called CDDO acid. The IUPAC name is (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylic acid. Its molecular formula is C31H41NO4. This chemical is a kind of organics. It should be stored in dry and cool environment.
The properties of the chemical are: (1)ACD/LogP: 5.76; (2)# of Rule of 5 Violations: 1 ; (3)#H bond acceptors: 5; (4)#H bond donors: 1; (5)#Freely Rotating Bonds: 1; (6)Polar Surface Area: 84.23Å2; (7)Index of Refraction: 1.574; (8)Molar Refractivity: 136.54 cm3; (9)Molar Volume: 413.4 cm3; (10)Polarizability: 54.13×10-24cm3; (11)Surface Tension: 51.1 dyne/cm; (12)Enthalpy of Vaporization: 102.11 kJ/mol; (13)Vapour Pressure: 1.2×10-17 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C4C(\C#N)=C/[C@@]5(/C3=C/C(=O)[C@H]2[C@](CC[C@@]1(C(=O)O)CCC(C)(C)C[C@H]12)(C)[C@]3(C)CC[C@H]5C4(C)C)C
(2)InChI: InChI=1/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22-28(5)15-18(17-32)24(34)27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36)/t19-,21-,23-,28-,29+,30+,31-/m0/s1
(3)InChIKey: TXGZJQLMVSIZEI-UQMAOPSPBH