Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

2-Fluoro-N-methylaniline

Related Products

Hot Products

Name

2-Fluoro-N-methylaniline

EINECS N/A
CAS No. 1978-38-7 Density 1.106 g/cm3
PSA 12.03000 LogP 1.94040
Solubility N/A Melting Point N/A
Formula C7H8FN Boiling Point 180.323 °C at 760 mmHg
Molecular Weight 125.146 Flash Point 62.857 °C
Transport Information N/A Appearance N/A
Safety 26-36/37/39 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 1978-38-7 (2-Fluoro-N-methylaniline) Hazard Symbols ToxicT
Synonyms

Aniline,o-fluoro-N-methyl- (6CI,8CI);N-Methyl-o-fluoroaniline;N-Methyl-2-fluoroaniline;N-(2-Fluorophenyl)methylamine;2-Fluoro-N-methylbenzenamine;N-methyl-2-fluoraniline;2-Fluoro-N-methylaniline;

Article Data 22

2-Fluoro-N-methylaniline Synthetic route

348-54-9

2-Fluoroaniline

616-38-6

carbonic acid dimethyl ester

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
under 760.051 Torr; Reagent/catalyst; Molecular sieve; Reflux; Green chemistry;99.4%
1272654-63-3

N-methyl-N-(2-fluorophenyl)formamide

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
With sulfuric acid; water at 80℃; for 5h;98.4%
With C18H37ClMoNO2P2; hydrogen; sodium triethylborohydride In tetrahydrofuran; toluene at 130℃; under 37503.8 Torr; for 24h; Autoclave; Glovebox;15 %Chromat.

N-(2-fluorophenyl)methanimine

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
With hydrogen at 120℃; under 7500.75 Torr; for 3h; Reagent/catalyst; Temperature; Pressure;96.6%
50-00-0

formaldehyd

348-54-9

2-Fluoroaniline

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
Stage #1: formaldehyd; 2-Fluoroaniline With potassium hydroxide In methanol at 85℃; for 2h; Sealed tube;
Stage #2: With methanol; sodium tetrahydroborate at 0 - 85℃; for 1h; Reagent/catalyst; Temperature; Sealed tube;
95%
With methanol; sodium tetrahydroborate; sodium at 60℃; for 2h;65%
348-54-9

2-Fluoroaniline

74-89-5

methylamine

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
Stage #1: 2-Fluoroaniline With hydrogenchloride In water for 0.5h;
Stage #2: With sodium nitrite In water at -10 - 5℃; for 1.5h;
Stage #3: methylamine In water at 50℃; for 2.5h; Temperature;
95%
900537-29-3

N-methyl-N-nosyl-o-fluoroaniline

68-11-1

mercaptoacetic acid

A

3406-75-5

2-(4-nitrophenylthio)acetic acid

B

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃;A n/a
B 88%
67-56-1

methanol

348-54-9

2-Fluoroaniline

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
With [Cp*Ir(2-(1H-benzo[d]imidazol-2-yl)-1H-benzo[d]imidazole)Cl][Cl]; caesium carbonate at 120℃; for 12h; Schlenk technique;87%
348-54-9

2-Fluoroaniline

74-88-4

methyl iodide

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
Stage #1: 2-Fluoroaniline With n-butyllithium In tetrahydrofuran; hexane at -50 - 20℃; for 1.25h;
Stage #2: methyl iodide In tetrahydrofuran; hexane for 5.25h; Further stages.;
80%
824-48-6

N-(2-fluorophenyl)formamide

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
In tetrahydrofuran; methanol59%
Stage #1: N-(2-fluorophenyl)formamide With borane In tetrahydrofuran Heating;
Stage #2: With hydrogenchloride In methanol; ethanol Further stages.;
With hydrogenchloride; sodium hydroxide; borane In tetrahydrofuran; 1,4-dioxane at 0 - 60℃; for 4h; Under argon gas;
348-54-9

2-Fluoroaniline

1978-38-7

2-fluoro-N-methylaniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 93 percent / pyridine / CH2Cl2 / 20 °C
2: 100 percent / CH2Cl2 / 0.17 h / 20 °C
3: 88 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: acetic anhydride / 2 h / 50 °C
1.2: 1 h / 20 °C
2.1: borane-THF / tetrahydrofuran / 2 h / 50 °C
2.2: 1 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Large scale
2: sodium hydride / mineral oil; tetrahydrofuran / 4 h / 0 °C / Large scale
3: ammonium hydroxide / water / 5 h / Reflux; Large scale
View Scheme
Multi-step reaction with 3 steps
1: toluene / 6 h / 88 - 110 °C
2: potassium carbonate / 4 h / 130 °C / 3000.3 - 4500.45 Torr / Autoclave
3: sulfuric acid; water / 5 h / 80 °C
View Scheme

2-Fluoro-N-methylaniline Specification

The 2-Fluoro-N-methylaniline, with the CAS registry number 1978-38-7, is also known as N-Methyl-2-fluoroaniline. It belongs to the product categories of Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals. This chemical's molecular formula is C7H8FN and molecular weight is 125.14. What's more, its systematic name is 2-Fluoro-N-methylaniline. It is used as pharmaceutical intermediates. This chemical should be sealed and stored in a cool and dry place. Moreover, it should be ensured that the workshop is well ventilated or equipped with exhaust devices. It should be protected from oxides.

Physical properties of 2-Fluoro-N-methylaniline are: (1)ACD/LogP: 1.887; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.88; (4)ACD/LogD (pH 7.4): 1.89; (5)ACD/BCF (pH 5.5): 15.76; (6)ACD/BCF (pH 7.4): 15.98; (7)ACD/KOC (pH 5.5): 249.57; (8)ACD/KOC (pH 7.4): 253.04; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 12.03 Å2; (13)Index of Refraction: 1.547; (14)Molar Refractivity: 35.856 cm3; (15)Molar Volume: 113.099 cm3; (16)Polarizability: 14.214×10-24cm3; (17)Surface Tension: 34.1 dyne/cm; (18)Density: 1.106 g/cm3; (19)Flash Point: 62.857 °C; (20)Enthalpy of Vaporization: 41.659 kJ/mol; (21)Boiling Point: 180.323 °C at 760 mmHg; (22)Vapour Pressure: 0.9 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: Fc1ccccc1NC
(2)Std. InChI: InChI=1S/C7H8FN/c1-9-7-5-3-2-4-6(7)8/h2-5,9H,1H3
(3)Std. InChIKey: LDVAIJZDACHGML-UHFFFAOYSA-N 

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1978-38-7