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Cas Database

Name	2-Hydroxynicotinic acid	EINECS	210-198-2
CAS No.	609-71-2	Density	1.451 g/cm³
PSA	70.42000	LogP	0.48540
Solubility	N/A	Melting Point	258-261 °C(lit.)
Formula	C₆H₅NO₃	Boiling Point	436 °C at 760 mmHg
Molecular Weight	139.111	Flash Point	217.5 °C
Transport Information	N/A	Appearance	white to light yellow powder
Safety	26-36-37/39	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	1,2-Dihydro-2-oxonicotinic acid;2-Hydroxy-3-pyridinecarboxylic acid;2-Hydroxy-3-Pyridine Carboxylic acid;2-oxo-1H-pyridine-3-carboxylic acid;2-oxo-1H-pyridine-3-carboxylate;1,2-Dihydro-2-oxo-3-pyridinecarboxylic acid;	Article Data	47

2-Hydroxynicotinic acid Synthetic route

: 2942-59-8
2-chloronicotinic acid

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
With hydrogenchloride; water for 6h; Heating;	92%
With copper(I) oxide; 2-pyridinealdoxime; cesium hydroxide; tetrabutylammomium bromide In water at 110℃; for 48h; Inert atmosphere;	63%
Heating;
With sodium hydroxide In ethanol; water

: 13466-43-8
3-bromo-pyridin-2-ol

: 124-38-9
carbon dioxide

: 609-71-2
2-hydroxy-3-carboxypyridine

Conditions

Conditions	Yield
Stage #1: 3-bromo-pyridin-2-ol With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.5h; Stage #3: carbon dioxide In tetrahydrofuran; hexane at -20℃; for 0.5h;	79%

: 2398-81-4
Nicotinic acid N-oxide

: 108-24-7
acetic anhydride

A: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

B: 609-71-2
2-hydroxy-3-carboxypyridine

C: 111068-01-0
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide

Conditions

Conditions	Yield
for 6h; Heating;	A 1.5% B 5.4% C 62%

: 2398-81-4
Nicotinic acid N-oxide

A: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

B: 609-71-2
2-hydroxy-3-carboxypyridine

C: 111068-01-0
3-acetoxy-4-aza-3-methyl-1(3H)-isobenzofuranone 4-oxide

Conditions

Conditions	Yield
With acetic anhydride for 6h; Heating;	A 1.5% B 5.4% C 62%

: 2942-59-8
2-chloronicotinic acid

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 5345-47-1
2-aminopyridin-3-carboxylic acid

Conditions

Conditions	Yield
With ammonium hydroxide at 155℃; for 20h;	A n/a B 60%

: 83164-33-4
N-(2,4-difluorophenyl)-2-(3-trifluoromethylphenoxy)-3-pyridinecarboxamide

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 98-17-9
3-Trifluoromethylphenol

C: 367-25-9
2,4-difluorophenylamine

D: 130191-66-1
N-(2,4-Difluorophenyl)-2-hydroxy-3-pyridinecarboxamide

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water for 48h; Heating;	A 57% B n/a C n/a D 28%
With hydrogenchloride; acetic acid In water for 48h; Product distribution; Mechanism; Heating;	A 57% B n/a C n/a D 28%

: 2398-81-4
Nicotinic acid N-oxide

: 123-62-6
propionic acid anhydride

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 6-hydroxynicotinic acid

C: 115147-79-0
5-aza-3-methyl-4-propionyloxyisocoumarin

D: 4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone 4-oxide

Conditions

Conditions	Yield
at 125℃; for 6h;	A n/a B n/a C 12.9% D 54.2%

...Expand

: 2398-81-4
Nicotinic acid N-oxide

: 123-62-6
propionic acid anhydride

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 6-hydroxynicotinic acid

C: 115147-79-0
5-aza-3-methyl-4-propionyloxyisocoumarin

D: 115147-80-3
4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone

Conditions

Conditions	Yield
at 160℃; for 4h; Yield given. Further byproducts given;	A n/a B n/a C 39.8% D 16.4%

...Expand

: 2398-81-4
Nicotinic acid N-oxide

: 123-62-6
propionic acid anhydride

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 6-hydroxynicotinic acid

C: 115147-79-0
5-aza-3-methyl-4-propionyloxyisocoumarin

D: 115147-80-3
4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone

E: 4-aza-3-ethyl-3-propionyloxy-1(3H)-isobenzofuranone 4-oxide

F: 115147-81-4
4-aza-3-ethyl-3,5-dipropionyloxy-1(3H)-isobenzofuranone

Conditions

Conditions	Yield
at 160℃; for 4h; Product distribution; Mechanism; various temperatures and times;	A n/a B n/a C 39.8% D 16.4% E 8.3% F 2.1%

...Expand

: 504-29-0
2-aminopyridine

: 2942-59-8
2-chloronicotinic acid

A: 609-71-2
2-hydroxy-3-carboxypyridine

B: 99973-09-8
2-hydroxy-nicotinic acid-[2]pyridylamide

C: 109255-91-6
2-(2-hydroxy-nicotinoylimino)-2H-[1,2']bipyridyl-3'-carboxylic acid

Conditions

Conditions	Yield
at 180 - 185℃;

2-Hydroxynicotinic acid Chemical Properties

Molecular Structure of 2-Hydroxynicotinic acid (CAS NO. 609-71-2):

IUPAC Name: 2-Oxo-1H-pyridine-3-carboxylic acid
Molecular Formula: C₆H₅NO₃
Molecular Weight: 139.108800 g/mol
Index of Refraction: 1.579
Molar Refractivity: 31.84 cm³
Molar Volume: 95.8 cm³
Surface Tension: 61 dyne/cm
Density: 1.451 g/cm³
Flash Point: 217.5 °C
Enthalpy of Vaporization: 75.92 kJ/mol
Boiling Point: 436 °C at 760 mmHg
Vapour Pressure: 8.03E-09 mmHg at 25 °C
Melting Point: 258-261 °C(lit.)
BRN: 119028
EINECS: 210-198-2
Product Categories: blocks;Carboxes;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Organic acids;CHIRAL CHEMICALS

2-Hydroxynicotinic acid Safety Profile

Safety Information of 2-Hydroxynicotinic acid (CAS NO. 609-71-2):
Hazard Codes: Xi
Hazard Note: Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing
S37/39:Wear suitable gloves and eye/face protection
WGK Germany: 3
HazardClass: IRRITANT

2-Hydroxynicotinic acid Specification

2-Hydroxynicotinic acid with cas registry number of 609-71-2 is also called NSC 226152 ; 1,2-Dihydro-2-oxo-3-pyridinecarboxylic acid ; 1,2-Dihydro-2-oxonicotinic acid .

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