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3-Bromo-1-propanol

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Name

3-Bromo-1-propanol

EINECS 210-986-6
CAS No. 627-18-9 Density 1.566 g/cm3
PSA 20.23000 LogP 0.76370
Solubility 167 g/L (20 °C) in water Melting Point N/A
Formula C3H7BrO Boiling Point 175.3 °C at 760 mmHg
Molecular Weight 138.992 Flash Point 93.9 °C
Transport Information N/A Appearance colourless liquid
Safety 26-39-37/39 Risk Codes 22-41-36/37/38
Molecular Structure Molecular Structure of 627-18-9 (3-Bromo-1-propanol) Hazard Symbols HarmfulXn, IrritantXi
Synonyms

1-Propanol, 3-bromo-;3-Bromopropan-1-ol;3-Hydroxypropyl bromide;1-Propanol,3-bromo-;4-01-00-01446 (Beilstein Handbook Reference);Trimethylene bromohydrin;4-amino uracil;

Article Data 39

3-Bromo-1-propanol Synthetic route

potassium (3-bromopropyl)trifluoroborate

627-18-9

1-bromo-3-propanol

Conditions
ConditionsYield
With Oxone; water In acetone at 20℃; for 0.0333333h;98%
33821-94-2

3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide

627-18-9

1-bromo-3-propanol

Conditions
ConditionsYield
With silica-supported NaHSO4 In methanol at 20℃; for 0.25h;93%
504-63-2

trimethyleneglycol

627-18-9

1-bromo-3-propanol

Conditions
ConditionsYield
With hydrogen bromide In benzene for 20h; Heating;90%
With hydrogen bromide In water; benzene for 28h; Heating;79%
With tetrabutylammomium bromide; hydrogen bromide In water for 0.0833333h; Microwave irradiation;75%
89031-84-5

3-(tert-butyldimethylsilyloxy)propyl bromide

627-18-9

1-bromo-3-propanol

Conditions
ConditionsYield
With Selectfluor In acetonitrile at 150℃; for 0.0833333h; Microwave irradiation;83%
With methanol; trimethylsilyl bromide at 20℃; for 0.0833333h; chemoselective reaction;83%
3395-91-3

Methyl 3-bromopropionate

627-18-9

1-bromo-3-propanol

Conditions
ConditionsYield
With zinc(II) tetrahydroborate In tetrahydrofuran at 67℃; for 2h;79%
503-30-0

trimethylene oxide

627-18-9

1-bromo-3-propanol

Conditions
ConditionsYield
With dimethylboron bromide; triethylamine In dichloromethane at 0℃; for 2h;78%
With sodium bromide at 50℃; for 18h; Green chemistry;29%
With diethyl ether; magnesium bromide zuletzt in Benzol bei Siedetemperatur;
590-92-1

3-Bromopropionic acid

627-18-9

1-bromo-3-propanol

Conditions
ConditionsYield
With zinc(II) tetrahydroborate In tetrahydrofuran for 6h; Heating;75%
503-30-0

trimethylene oxide

925-90-6

ethylmagnesium bromide

A

71-41-0

pentan-1-ol

B

627-18-9

1-bromo-3-propanol

Conditions
ConditionsYield
With diethyl ether
503-30-0

trimethylene oxide

ethylmagnesium bromide

A

71-41-0

pentan-1-ol

B

627-18-9

1-bromo-3-propanol

4176-55-0

2-oxo-1,3,2-dioxathiane

60-29-7

diethyl ether

phenylmagnesium bromide

A

92-52-4

biphenyl

B

945-51-7

1,1'-sulfinylbisbenzene

C

627-18-9

1-bromo-3-propanol

3-Bromo-1-propanol Chemical Properties

Product Name: 3-Bromo-1-propanol (CAS NO.627-18-9)

Molecular Formula: C3H7BrO
Molar mass:138.99108 g/mol
Density: 1.566 g/cm3                                
Flash Point: 93.9 °C                 
Boiling Point: 175.3 °C at 760 mmHg              
Index of Refraction:1.48 
Vapour Pressure: 0.357 mmHg at 25°C        
Water solubility: 167 g/L (20°C)
Storage temp: 2-8°C
Appearance: colourless liquid
XLogP3-AA: 0.7
H-Bond Donor: 1
H-Bond Acceptor: 1
Structure Descriptors of 3-Bromo-1-propanol (CAS NO.627-18-9):
  IUPAC Name: 3-bromopropan-1-ol
  Canonical SMILES: C(CO)CBr
  InChI: InChI=1S/C3H7BrO/c4-2-1-3-5/h5H,1-3H2 
  InChIKey: RQFUZUMFPRMVDX-UHFFFAOYSA-N
Product Categories: Aliphatics; Halides; omega-Bromoalkanols; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides

3-Bromo-1-propanol Uses

 3-Bromo-1-propanol (CAS NO.627-18-9) can be used as a raw material in organic synthesis ,and is an important chemical intermediate.

3-Bromo-1-propanol Toxicity Data With Reference

1.    

mmo-sat 177 µg/plate

    MUREAV    Mutation Research. 57 (1978),381.

3-Bromo-1-propanol Safety Profile

Mutation data reported. When heated to decomposition it emits toxic fumes of Br. See also BROMIDES.
Hazard Codes:Xn,Xi
Risk Statements:
22:  Harmful if swallowed 
36:  Irritating to the eyes
37:  Irritating to the respiratory system
38:  Irritating to the skin
41:  In case of fire and/or explosion do not breathe fumes
Safety Statements:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37:  Wear suitable gloves
39:  Wear eye/face protection

3-Bromo-1-propanol Specification

 3-Bromo-1-propanol , its CAS NO. is 627-18-9, the synonyms are 3-Bromopropan-1-ol ; 3-Hydroxypropyl bromide ; Trimethylene bromohydrin ; 1-Propanol, 3-bromo- ; 1-Bromo-3-propanol .

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