60-29-7

   Alchemist Raymundus Lullus is credited with discovering the compound in 1275 AD, although there is no contemporary evidence of this. 
   Ethyl ether (CAS NO.60-29-7) was first synthesized in 1540 by Valerius Cordus, who called it "oil of sweet vitriol" (oleum dulcis vitrioli)—the name was because it was originally discovered by distilling a mixture of ethanol and sulfuric acid (then known as oil of vitriol)—and noted some of its medicinal properties. At about the same time, Theophrastus Bombastus von Hohenheim, better known as Paracelsus, discovered ether's analgesic properties. In 1730 ,August Siegmund Frobenius gave the name ether  to the substance  .

IARC Cancer Review: Animal No Adequate Data IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 93.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

OSHA PEL: TWA 400 ppm; STEL 500 ppm
ACGIH TLV: TWA 400 ppm; STEL 500 ppm
DFG MAK: 400 ppm (1200 mg/m³)
DOT Classification:  3; Label: Flammable Liquid

For occupational chemical analysis use NIOSH: Ethyl Ether, 1610.

The Ethyl ether with CAS registry number of 60-29-7 is also known as Diethyl ether. The IUPAC name is Ethoxyethane. It belongs to product categories of Refrigerants; Anhydrous Solvents; Synthetic Organic Chemistry; Chemistry. Its EINECS registry number is 200-467-2. In addition, the formula is C₄H₁₀O and the molecular weight is 74.12. This chemical is a colourless liquid and should be cool and dry place away from oxidizing agents.

Physical properties about Ethyl ether are: (1)ACD/LogP: 1.04; (2)ACD/LogD (pH 5.5): 1.041; (3)ACD/LogD (pH 7.4): 1.041; (4)ACD/BCF (pH 5.5): 3.638; (5)ACD/BCF (pH 7.4): 3.638; (6)ACD/KOC (pH 5.5): 87.722; (7)ACD/KOC (pH 7.4): 87.722; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 2; (10)Polar Surface Area: 9.23Ų; (11)Index of Refraction: 1.361; (12)Molar Refractivity: 22.326 cm³; (13)Molar Volume: 100.925 cm³; (14)Surface Tension: 19.09 dyne/cm; (15)Density: 0.734 g/cm³; (16)Enthalpy of Vaporization: 26.52 kJ/mol; (17)Boiling Point: 33.177 °C at 760 mmHg; (18)Vapour Pressure: 566.752 mmHg at 25 °C.

Preparation of Ethyl ether. Firstly, mix ethanol (95%) and concentrated sulfuric acid (98%) with ratio of 1:1 and heat the reaction mixture to 83 °C. Then pass into ethanol vapor and stir the mixture at 120-125 °C. After the reaction, gaseous product is washed through sodium hydroxide solution, saturated solution of sodium bisulfite and distilled water at atmospheric pressure. At last, product is obtained by collecting fraction of 33.5-34.5 °C.

Uses of Ethyl ether: it is important anesthetic in medicine. Besides, it is used as analytical reagent for nickel, potassium, magnesium and other analysis. What's more, it is used as solvent, cleaning agent and also used in medicine, electronic and other industries. For example, it is used to produce benzoic acid ethyl ester by reaction with benzoyl chloride. The reaction needs catalyst anhydrous cobalt(II) chloride and solvent acetonitrile at ambient temperature for 8 hours. The tield is about 49%.

When you are using this chemical, please be cautious about it. As a chemical, it is extremely flammable and may form explosive peroxides. What's more, it has danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. Besides, its repeated exposure may cause skin dryness or cracking vapours may cause drowsiness and dizziness. During using it, wear suitable protective clothing and gloves and do not empty into drains. Keep container in a well-ventilated place and away from sources of ignition. In case of accident or if you feel unwell seek medical advice immediately. It is necessary to take precautionary measures against static discharges.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: CCOCC
2. InChI: InChI=1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3
3. InChIKey: RTZKZFJDLAIYFH-UHFFFAOYSA-N

The toxicity data is as follows: