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Name	4,6-Dichloropyrimidine	EINECS	214-770-2
CAS No.	1193-21-1	Density	1.493 g/cm³
PSA	25.78000	LogP	1.78340
Solubility	N/A	Melting Point	65-67 °C(lit.)
Formula	C₄H₂Cl₂N₂	Boiling Point	176 °C at 760 mmHg
Molecular Weight	148.979	Flash Point	105.1 °C
Transport Information	UN 3263 8/PG 2	Appearance	Yellow Solid
Safety	26-36/37/39-45-27	Risk Codes	34-20/21/22-36/37
Molecular Structure		Hazard Symbols	C
Synonyms	4,6-Dichloro Pyrimidine;Pyrimidine, 4,6-dichloro-;	Article Data	40

4,6-Dichloropyrimidine Synthetic route

: 104-90-5
5-ethyl-2-methyl-pyridine

: 1193-24-4
4,6-pyrimidinediol

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With trichlorophosphate	100%
With trichlorophosphate	98%

: 1193-24-4
4,6-pyrimidinediol

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With triethylamine; trichlorophosphate at 40 - 105℃; for 2h;	99.1%
With chlorine; magnesium chloride; phosphorus trichloride In trichlorophosphate at 66℃; under 750.075 Torr; for 3.5h; Reagent/catalyst; Temperature; Pressure; Solvent;	99.83%
With bis(trichloromethyl) carbonate; sulfuric acid In N,N-dimethyl-formamide; 1,2-dichloro-benzene at 80℃; for 4.2h; Temperature; Solvent; Industrial scale;	97%

: 2434-56-2
4,6-diaminopyrimidine

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
Stage #1: 4,6-diaminopyrimidine With hydrogenchloride; sodium nitrite In water at -5℃; for 2h; Stage #2: With hydrogenchloride; copper(l) chloride In water at 45℃; for 2h;	86.4%

: 75-44-5
phosgene

: 1193-24-4
4,6-pyrimidinediol

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With 2,3-Dimethylaniline In dichloromethane; water	80%
With N-ethyl-N,N-diisopropylamine In water; acetonitrile

: 89283-48-7
4-chloro-6-methylsulfanylpyrimidine

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With sulfuryl dichloride In dichloromethane; acetonitrile at 0℃; for 0.5h;	76%

: 75-44-5
phosgene

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 75-05-8
acetonitrile

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
at 20 - 140℃; under 982.607 - 20686.5 Torr; for 3h; the Parr Reactor (17328-33);	62.21%
at 105℃; under 5999.08 - 8378.02 Torr; for 3h;
With hydrogenchloride In chlorobenzene at 105℃; under 11739.6 Torr; for 23.5h;

: 25286-58-2
1H-pyrimidine-4,6-dione

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With pyridine; trichlorophosphate
With N,N-dimethyl-aniline; trichlorophosphate

: C6(2)H6*C4H2Cl2N2

A: 1193-21-1
4,6-dichloropyrimidine

B: 1076-43-3
benzene-d6

Conditions

Conditions	Yield
In tetrachloromethane at 34.9℃; Equilibrium constant;

: 60-35-5
acetamide

: 75-44-5
phosgene

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
In chlorobenzene at 75 - 105℃; under 4913.04 - 17583.5 Torr; for 1.66667 - 23.1667h;

: 75-44-5
phosgene

: 623-49-4
ethyl cyanoformate

: 75-05-8
acetonitrile

: 1193-21-1
4,6-dichloropyrimidine

Conditions

Conditions	Yield
With hydrogenchloride at 52 - 74℃;

4,6-Dichloropyrimidine Chemical Properties

IUPAC Name: 4,6-Dichloropyrimidine
Synonyms of 4,6-Dichloropyrimidine (CAS NO.1193-21-1): Pyrimidine, 4,6-dichloro-
CAS NO: 1193-21-1
Molecular Formula: C₄H₂Cl₂N₂
Molecular Weight: 148.98
Molecular Structure:
EINECS: 214-770-2
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 25.78 Å²
Index of Refraction: 1.559
Molar Refractivity: 32.22 cm³
Molar Volume: 99.7 cm³
Surface Tension: 51.5 dyne/cm
Density: 1.493 g/cm³
Flash Point: 105.1 °C
Enthalpy of Vaporization: 39.54 kJ/mol
Boiling Point: 176 °C at 760 mmHg
Vapour Pressure: 1.5 mmHg at 25°C
Melting Point: 65-67 °C(lit.)
Appearance:Yellow Solid
Product Categories of 4,6-Dichloropyrimidine (CAS NO.1193-21-1): PYRIMIDINE;FINE Chemical & INTERMEDIATES;Halides;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Pyrazines, Pyrimidines & Pyridazines;Nucleotides and Nucleosides;Pyrimidines;Bases & Related Reagents;Nucleotides;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks

4,6-Dichloropyrimidine Uses

4,6-Dichloropyrimidine (CAS NO.1193-21-1) is used as intermediate in the synthesis of pharmaceutical.

4,6-Dichloropyrimidine Safety Profile

Safety Information about 4,6-Dichloropyrimidine (CAS NO.1193-21-1):
Hazard Codes : C
The Risk Statements: 34-20/21/22-36/37
34: Causes burns
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37: Irritating to eyes and respiratory system
The Safety Statements: 26-36/37/39-45-27
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR:UN 3263 8/PG 2
F:19
WGK Germany:3
Hazard Note : Corrosive
HazardClass :8

4,6-Dichloropyrimidine Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use foam, dry chemical, or carbon dioxide.
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

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