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Cas Database |
| Name |
4-Acryloylmorpholine |
EINECS | 418-140-1 |
| CAS No. | 5117-12-4 | Density | 1.122 |
| PSA | 29.54000 | LogP | -0.03090 |
| Solubility | 1000g/L at 20℃ | Melting Point |
-35 ºC |
| Formula | C7H11 N O2 | Boiling Point | 296.8 °C at 760 mmHg |
| Molecular Weight | 141.17 | Flash Point | >110 ºC |
| Transport Information | N/A | Appearance | N/A |
| Safety | S23;S26;S36/37/39 | Risk Codes | R22;R41;R43;R48/22 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
Morpholine,4-(1-oxo-2-propenyl)- (9CI); Morpholine, 4-acryloyl- (6CI,7CI,8CI);1-(Morpholin-4-yl)propenone; 4-Acryloylmorpholine; A-MO; ACMO;Acryloylmorpholine; Kayarad RM 1001; MA 1; MA 1 (amide); N-Acryloylmorpholine;NK Ester A-MO; NSC 162221 |
Article Data | 56 |
4-Acryloylmorpholine Synthetic route
- 5117-12-4
N-Acryloylmorpholine
| Conditions | Yield |
|---|---|
| With 10H-phenothiazine; sodium methylate In glycerol at 200℃; Pyrolysis; | 97% |
- 27097-66-1
(+/-)-2-hydroxy-1-morpholinopropan-1-one
- 5117-12-4
N-Acryloylmorpholine
| Conditions | Yield |
|---|---|
| With sulfuric acid; acetic anhydride at 550℃; Temperature; | 96.1% |
- 860248-52-8
4-(3-methoxy-propionyl)-morpholine
- 5117-12-4
N-Acryloylmorpholine
| Conditions | Yield |
|---|---|
| With sodium methylate; 4-methoxy-phenol at 200℃; Pyrolysis; | 96% |
| With lithium phosphate at 390℃; Pyrolysis; |
- 3773-84-0
β-morpholinyl-N,N-morpholinylpropionic acid amide
- 108-24-7
acetic anhydride
A
- 1696-20-4
4-acetylmorpholine
B
- 5117-12-4
N-Acryloylmorpholine
| Conditions | Yield |
|---|---|
| Stage #1: β-morpholinyl-N,N-morpholinylpropionic acid amide; acetic anhydride In toluene at 20 - 80℃; for 2h; Inert atmosphere; Stage #2: With 2,6-di-tert-butyl-4-methyl-phenol; N-ethyl-N,N-diisopropylamine for 18h; Reagent/catalyst; Temperature; Reflux; | A 84% B 95% |
- 5117-12-4
N-Acryloylmorpholine
| Conditions | Yield |
|---|---|
| Stage #1: 3-(diethylamino)-1-morpholinopropan-1-one With acetic anhydride In toluene at 20 - 80℃; for 2h; Inert atmosphere; Stage #2: With 2,6-di-tert-butyl-4-methyl-phenol; triethylamine Reflux; | 94% |
| With 4-methoxy-phenol | 11.8 g |
| Conditions | Yield |
|---|---|
| With 10H-phenothiazine; sulfuric acid for 2h; Reagent/catalyst; Heating; | 93.12% |
- 5117-12-4
N-Acryloylmorpholine
| Conditions | Yield |
|---|---|
| With 10H-phenothiazine; sodium methylate; 4-methoxy-phenol In glycerol at 160℃; Pyrolysis; | 92% |
| Conditions | Yield |
|---|---|
| With sodium ethanolate In ethanol at 78℃; for 5h; Temperature; | 91.5% |
- 30668-14-5
1-morpholinopropane-1-one
- 5117-12-4
N-Acryloylmorpholine
| Conditions | Yield |
|---|---|
| With potassium tert-butylate; oxygen; palladium diacetate In dimethyl sulfoxide at 90 - 120℃; under 760.051 Torr; for 36h; Reagent/catalyst; Temperature; | 90% |
| Conditions | Yield |
|---|---|
| With triethylamine at 0 - 3℃; for 2h; Reagent/catalyst; Temperature; | 89.95% |
4-Acryloylmorpholine Chemical Properties
The molecular structure of 2-Propen-1-one,1-(4-morpholinyl)- (CAS NO.5117-12-4) is
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IUPAC Name: 1-Morpholin-4-ylprop-2-en-1-one
Canonical SMILES: C=CC(=O)N1CCOCC1
Molecular Formula: C7H11 N O2
Molecular Weight: 141.17
Density: 1.074 g/cm3
Melting Point: -35 ºC
Boiling Point: 296.8 °C at 760 mmHg
Flash Point: 133.3 °C
Freely Rotating Bonds: 1
Polar Surface Area: 29.54 Å2
Index of Refraction: 1.477
Molar Refractivity: 37.18 cm3
Molar Volume: 131.4 cm3
Polarizability: 14.74× 10-24 cm3
Surface Tension: 35.9 dyne/cm
Enthalpy of Vaporization: 53.66 kJ/mol
Vapour Pressure: 0.00141 mmHg at 25°C
The Cas Register Number of 2-Propen-1-one,1-(4-morpholinyl)- is 5117-12-4. The chemical synonyms of 2-Propen-1-one,1-(4-morpholinyl)- (CAS NO.5117-12-4) are Acryloyl morpholine;4-Acryloylmorpholine ; N-Acryloylmorpholine ; 4-(1-Oxo-2-propenyl)-Morpholine ; N-Acrolylmorpholine ; N-Acrylylmorpholine ; 4-Acryloylmorpholine,98+% ; Morpholine, 4-(1-oxo-2-propenyl)- . Its product categories are Acrylate ; Acrylic Monomers ; Monomers .
4-Acryloylmorpholine Uses
2-Propen-1-one,1-(4-morpholinyl)- (CAS NO.5117-12-4) isused as pharmaceutical intermediate.
4-Acryloylmorpholine Safety Profile
Hazard Codes: 
Xn
Risk Statements: 22-41-43-48/22
R22: Harmful if swallowed.
R41: Risk of serious damage to the eyes.
R43: May cause sensitization by skin contact.
R48/22: Harmful: danger of serious damage to health by prolonged exposure if swallowed.
Safety Statements: 23-26-36/37/39
S23: Do not breathe vapour.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 2
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