CAS No.110-91-8,Morpholine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	110-91-8
Name:	Morpholine
Article Data:	311
Cas Database

Formula:	C₄H₉NO
Molecular Weight:	87.1216
Synonyms:	Diethylenimide oxide;Drewamine;BASF 238;1-Oxa-4-azacyclohexane;Tetrahydro-2H-1,4-oxazine;Morpholine (4-oxazine);Tetrahydro-p-oxazine;Diethyleneimide oxide;Diethylene oximide;Tetrahydro-1,4-oxazine;2H-1,4-Oxazine, tetrahydro-;Morpholine hydrochloride;p-Isoxazine, tetrahydro-;Diethylene imidoxide;Tetrahydro-1, 4-isoxazine;1-oxa-4-azoniacyclohexane;4H-1,4-Oxazine, tetrahydro-;
EINECS:	203-815-1
Density:	0.931 g/cm³
Melting Point:	-5 °C
Boiling Point:	128.9 °C at 760 mmHg
Flash Point:	35.6 °C
Solubility:	miscible with water.
Appearance:	aqueous solution with a fishlike odor
Hazard Symbols:	C
Risk Codes:	10-20/21/22-34
Safety:	23-36-45
Transport Information:	UN 2054 8/PG 1
PSA:	21.26000
LogP:	-0.06500

Synthetic route

: (1S,2S,5R,6R,7S,8S)-1,6-Dimethyl-8-morpholin-4-yl-3,4-diaza-tricyclo[3.2.1.02,7]oct-3-ene-2,5-dicarboxylic acid dimethyl ester

A: 110-91-8
morpholine

B: 2166-25-8
dimethyl 4-methylpyridazine-3,6-dicarboxylate

Conditions

Conditions	Yield
In xylene for 6h; Heating;	A n/a B 100%
under 0.075006 Torr; Pyrolysis;

: 25070-77-3
allyl morpholine-1-carboxylate

A: 110-91-8
morpholine

B: 696-57-1
N-allylmorpholine

Conditions

Conditions	Yield
With diethylamine; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine In water for 0.166667h; Ambient temperature;	A 98% B 2%
With formic acid; triphenylphosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In tetrahydrofuran at 30℃; for 3h;	A 16 % Chromat. B 84 % Chromat.

: 111-46-6
diethylene glycol

A: 110-91-8
morpholine

B: 109-02-4
4-methyl-morpholine

Conditions

Conditions	Yield
With methylamine	A 98% B n/a

: 4837-31-4
4-Phenylsulfanyl-morpholine

: 691-96-3
diisopropyl phosphite

A: 110-91-8
morpholine

B: 15267-38-6
thiophosphoric acid O,O'-diisopropyl ester S-phenyl ester

Conditions

Conditions	Yield
	A n/a B 96%

...Expand

: 114406-39-2
prop-2-yn-1-yl morpholine-4-carboxylate

: 110-91-8
morpholine

Conditions

Conditions	Yield
With benzyltriethylammonium tetrathiomolybdate In acetonitrile at 20℃; for 2.5h;	95%
With potassium tetrachloroplatinate(II) In d(4)-methanol; water-d2 at 20℃; for 14h; Reagent/catalyst;

: 4394-85-8
4-morpholinecarboxaldehyde

: 110-91-8
morpholine

Conditions

Conditions	Yield
With Ru-MACHO; potassium tert-butylate; hydrogen In tetrahydrofuran at 140℃; under 38002.6 Torr; for 2.5h; Catalytic behavior; Temperature; Glovebox; Autoclave; Cooling with ice;	95%
With [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amide](carbonyl)(hydride)iron(II); hydrogen In tetrahydrofuran at 100℃; under 22801.5 Torr; for 4h; Catalytic behavior;

: 437-81-0
2,6-difluorobenzaldehyde

: 2365-48-2
Methyl thioglycolate

: 95-15-8
Benzo[b]thiophene

A: 110-91-8
morpholine

B 2-(1-Morpholino)-6-fluorobenzaldehyde: 2-(1-Morpholino)-6-fluorobenzaldehyde

Conditions

Conditions	Yield
With triethylamine In NaH; dimethyl sulfoxide; acetonitrile	A 93% B n/a

...Expand

: 112918-83-9
4-(9-fluorenylmethoxycarbonyl)morpholine

: 110-91-8
morpholine

Conditions

Conditions	Yield
With triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate In neat (no solvent) at 25℃; for 0.0666667h; Green chemistry;	93%

: 7529-22-8
4-methylmorpholine N-oxide

: 110-91-8
morpholine

Conditions

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine; potassium carbonate In chloroform at 0 - 20℃;	92%

: 779-53-3
4-morpholinylacetophenone

: 110-91-8
morpholine

Conditions

Conditions	Yield
With magnesium; acetic acid In methanol at 20℃;	92%

Raw Materials

519-73-3

Downstream Products

949-01-9

71-36-3

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Chemistry

Molecular structure of Morpholine (CAS NO.110-91-8) is:

Product Name: Morpholine
CAS Registry Number: 110-91-8
IUPAC Name: morpholine
Molecular Weight: 87.12036 [g/mol]
Molecular Formula: C₄H₉NO
XLogP3: -0.9
H-Bond Donor: 1
H-Bond Acceptor: 2
EINECS: 203-815-1
Melting Point: -5 °C
Refractive index: n20/D 1.454(lit.)
Storage temp.: Store at R.T.
Water Solubility: MISCIBLE
Sensitive: Hygroscopic
Surface Tension: 29.2 dyne/cm
Density: 0.931 g/cm³
Flash Point: 35.6 °C
Enthalpy of Vaporization: 36.66 kJ/mol
Boiling Point: 128.9 °C at 760 mmHg
Vapour Pressure: 10.4 mmHg at 25°C
Product Categories: Organic Chemicals;BasesChemical Synthesis;Organic Bases;Supported Reagents;Supported Synthesis;Synthetic Reagents

Uses

Morpholine (CAS NO.110-91-8) is a common additive because its volatility is about the same as water. Morpholine is often used in conjunction with low concentrations of hydrazine or ammonia to provide a comprehensive all-volatile treatment chemistry for corrosion protection for the steam systems of such plants.

Production

Morpholine (CAS NO.110-91-8) may be produced by the dehydration of diethanolamine with sulfuric acid.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	oral	100mg/kg (100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 236, 1939.
mammal (species unspecified)	LC50	inhalation	12000mg/m³ (12000mg/m³)		Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mammal (species unspecified)	LD50	oral	1220mg/kg (1220mg/kg)		Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mouse	LC50	inhalation	1320mg/m³/2H (1320mg/m³)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 8, Pg. 60, 1966.
mouse	LD50	intraperitoneal	413mg/kg (413mg/kg)		Cancer Vol. 2, Pg. 1055, 1949.
mouse	LD50	oral	525mg/kg (525mg/kg)	BEHAVIORAL: SLEEP BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Biomedica Biochimica Acta. Vol. 44, Pg. 795, 1985.
mouse	LD50	subcutaneous	458mg/kg (458mg/kg)		United States Patent Document. Vol. #4576951,
rabbit	LD50	skin	500uL/kg (0.5mL/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rat	LC50	inhalation	8000ppm/8H (8000ppm)		Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 85, 1974.
rat	LD50	oral	1450mg/kg (1450mg/kg)		Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 25, 1968.
rat	LDLo	unreported	1600mg/kg (1600mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 662, 1969.

Safety Profile

Moderately toxic by ingestion, inhalation, skin contact, and intraperitoneal routes. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Can cause kidney damage. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid. A very dangerous fire hazard when exposed to flame, heat, or oxidizers; can react with oxidizing materials. To fight fire, use alcohol foam, CO₂, dry chemical. Mixtures with nitromethane are explosive. May ignite spontaneously in contact with cellulose nitrate of high surface area. When heated to decomposition it emits highly toxic fumes of NO_x.
Hazard Codes: Corrosive C
Risk Statements: 10-20/21/22-34
R10:Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
Safety Statements: 23-36-45
S23:Do not breathe vapour.
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2054 8/PG 1
WGK Germany: 3
RTECS: QD6475000
HazardClass: 8
PackingGroup: I

Specification

Morpholine , its cas register number is 110-91-8. It also can be called Tetrahydro-1,4-oxazine ; 1-Oxa-4-azacyclohexane ; 2H-1,4-Oxazine, tetrahydro- ; 4H-1,4-Oxazine, tetrahydro- ; Diethylene imidoxide ; Diethylene oximide ; Tetrahydro-1,4-isoxazine ; Tetrahydro-1,4-oxazine ; Tetrahydro-p-oxazine ; p-Isoxazine, tetrahydro- .It is a aqueous solution with a fishlike odor.It is highly flammable and water soluble.It dissolved in water neutralizes acids in exothermic reactions to form salts plus water. It may cause toxic effects if inhaled or ingested/swallowed. Morpholine decomposes reasonably slowly in the absence of oxygen even at the high temperatures and pressures in these steam systems.