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| CAS No.: | 110-91-8 |
|---|---|
| Name: | Morpholine |
| Molecular Structure: | |
|
|
|
| Formula: | C4H9NO |
| Molecular Weight: | 87.1216 |
| Synonyms: | Diethylenimide oxide;Drewamine;BASF 238;1-Oxa-4-azacyclohexane;Tetrahydro-2H-1,4-oxazine;Morpholine (4-oxazine);Tetrahydro-p-oxazine;Diethyleneimide oxide;Diethylene oximide;Tetrahydro-1,4-oxazine;2H-1,4-Oxazine, tetrahydro-;Morpholine hydrochloride;p-Isoxazine, tetrahydro-;Diethylene imidoxide;Tetrahydro-1, 4-isoxazine;1-oxa-4-azoniacyclohexane;4H-1,4-Oxazine, tetrahydro-; |
| EINECS: | 203-815-1 |
| Density: | 0.931 g/cm3 |
| Melting Point: | -5 °C |
| Boiling Point: | 128.9 °C at 760 mmHg |
| Flash Point: | 35.6 °C |
| Solubility: | miscible with water. |
| Appearance: | aqueous solution with a fishlike odor |
| Hazard Symbols: |
 C
|
| Risk Codes: | 10-20/21/22-34 |
| Safety: | 23-36-45 |
| Transport Information: | UN 2054 8/PG 1 |
| PSA: | 21.26000 |
| LogP: | -0.06500 |
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| Conditions | Yield |
|---|---|
| In xylene for 6h; Heating; | A n/a B 100% |
| under 0.075006 Torr; Pyrolysis; |
| Conditions | Yield |
|---|---|
| With diethylamine; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine In water for 0.166667h; Ambient temperature; | A 98% B 2% |
| With formic acid; triphenylphosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In tetrahydrofuran at 30℃; for 3h; | A 16 % Chromat. B 84 % Chromat. |
| Conditions | Yield |
|---|---|
| With methylamine | A 98% B n/a |
- 4837-31-4
4-Phenylsulfanyl-morpholine
- 691-96-3
diisopropyl phosphite
A
- 110-91-8
morpholine
B
- 15267-38-6
thiophosphoric acid O,O'-diisopropyl ester S-phenyl ester
| Conditions | Yield |
|---|---|
| A n/a B 96% |
- 114406-39-2
prop-2-yn-1-yl morpholine-4-carboxylate
- 110-91-8
morpholine
| Conditions | Yield |
|---|---|
| With benzyltriethylammonium tetrathiomolybdate In acetonitrile at 20℃; for 2.5h; | 95% |
| With potassium tetrachloroplatinate(II) In d(4)-methanol; water-d2 at 20℃; for 14h; Reagent/catalyst; |
| Conditions | Yield |
|---|---|
| With Ru-MACHO; potassium tert-butylate; hydrogen In tetrahydrofuran at 140℃; under 38002.6 Torr; for 2.5h; Catalytic behavior; Temperature; Glovebox; Autoclave; Cooling with ice; | 95% |
| With [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amide](carbonyl)(hydride)iron(II); hydrogen In tetrahydrofuran at 100℃; under 22801.5 Torr; for 4h; Catalytic behavior; |
- 437-81-0
2,6-difluorobenzaldehyde
- 2365-48-2
Methyl thioglycolate
- 95-15-8
Benzo[b]thiophene
A
- 110-91-8
morpholine
| Conditions | Yield |
|---|---|
| With triethylamine In NaH; dimethyl sulfoxide; acetonitrile | A 93% B n/a |
- 112918-83-9
4-(9-fluorenylmethoxycarbonyl)morpholine
- 110-91-8
morpholine
| Conditions | Yield |
|---|---|
| With triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate In neat (no solvent) at 25℃; for 0.0666667h; Green chemistry; | 93% |
| Conditions | Yield |
|---|---|
| With 1,3,5-trichloro-2,4,6-triazine; potassium carbonate In chloroform at 0 - 20℃; | 92% |
| Conditions | Yield |
|---|---|
| With magnesium; acetic acid In methanol at 20℃; | 92% |
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- 141-32-2Butyl acrylate
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- 104987-11-3Tacrolimus
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- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- Total:37 Page 1 of 1 1
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Chemistry
Molecular structure of Morpholine (CAS NO.110-91-8) is:
Product Name: Morpholine
CAS Registry Number: 110-91-8
IUPAC Name: morpholine
Molecular Weight: 87.12036 [g/mol]
Molecular Formula: C4H9NO
XLogP3: -0.9
H-Bond Donor: 1
H-Bond Acceptor: 2
EINECS: 203-815-1
Melting Point: -5 °C
Refractive index: n20/D 1.454(lit.)
Storage temp.: Store at R.T.
Water Solubility: MISCIBLE
Sensitive: Hygroscopic
Surface Tension: 29.2 dyne/cm
Density: 0.931 g/cm3
Flash Point: 35.6 °C
Enthalpy of Vaporization: 36.66 kJ/mol
Boiling Point: 128.9 °C at 760 mmHg
Vapour Pressure: 10.4 mmHg at 25°C
Product Categories: Organic Chemicals;BasesChemical Synthesis;Organic Bases;Supported Reagents;Supported Synthesis;Synthetic Reagents
Uses
Morpholine (CAS NO.110-91-8) is a common additive because its volatility is about the same as water. Morpholine is often used in conjunction with low concentrations of hydrazine or ammonia to provide a comprehensive all-volatile treatment chemistry for corrosion protection for the steam systems of such plants.
Production
Morpholine (CAS NO.110-91-8) may be produced by the dehydration of diethanolamine with sulfuric acid.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | oral | 100mg/kg (100mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE | Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 236, 1939. |
| mammal (species unspecified) | LC50 | inhalation | 12000mg/m3 (12000mg/m3) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975. | |
| mammal (species unspecified) | LD50 | oral | 1220mg/kg (1220mg/kg) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975. | |
| mouse | LC50 | inhalation | 1320mg/m3/2H (1320mg/m3) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 8, Pg. 60, 1966. |
| mouse | LD50 | intraperitoneal | 413mg/kg (413mg/kg) | Cancer Vol. 2, Pg. 1055, 1949. | |
| mouse | LD50 | oral | 525mg/kg (525mg/kg) | BEHAVIORAL: SLEEP BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Biomedica Biochimica Acta. Vol. 44, Pg. 795, 1985. |
| mouse | LD50 | subcutaneous | 458mg/kg (458mg/kg) | United States Patent Document. Vol. #4576951, | |
| rabbit | LD50 | skin | 500uL/kg (0.5mL/kg) | AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954. | |
| rat | LC50 | inhalation | 8000ppm/8H (8000ppm) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 85, 1974. | |
| rat | LD50 | oral | 1450mg/kg (1450mg/kg) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 25, 1968. | |
| rat | LDLo | unreported | 1600mg/kg (1600mg/kg) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 662, 1969. |
Safety Profile
Moderately toxic by ingestion, inhalation, skin contact, and intraperitoneal routes. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Can cause kidney damage. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid. A very dangerous fire hazard when exposed to flame, heat, or oxidizers; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. Mixtures with nitromethane are explosive. May ignite spontaneously in contact with cellulose nitrate of high surface area. When heated to decomposition it emits highly toxic fumes of NOx.
Hazard Codes: 
C
Risk Statements: 10-20/21/22-34
R10:Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
Safety Statements: 23-36-45
S23:Do not breathe vapour.
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2054 8/PG 1
WGK Germany: 3
RTECS: QD6475000
HazardClass: 8
PackingGroup: I
Specification
Morpholine , its cas register number is 110-91-8. It also can be called Tetrahydro-1,4-oxazine ; 1-Oxa-4-azacyclohexane ; 2H-1,4-Oxazine, tetrahydro- ; 4H-1,4-Oxazine, tetrahydro- ; Diethylene imidoxide ; Diethylene oximide ; Tetrahydro-1,4-isoxazine ; Tetrahydro-1,4-oxazine ; Tetrahydro-p-oxazine ; p-Isoxazine, tetrahydro- .It is a aqueous solution with a fishlike odor.It is highly flammable and water soluble.It dissolved in water neutralizes acids in exothermic reactions to form salts plus water. It may cause toxic effects if inhaled or ingested/swallowed. Morpholine decomposes reasonably slowly in the absence of oxygen even at the high temperatures and pressures in these steam systems.
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