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| CAS No.: | 1393-62-0 |
|---|---|
| Name: | Abrin |
| Molecular Structure: | |
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| Formula: | N/A |
| Molecular Weight: | 0 |
| Synonyms: | Abrin;Toxalbumin |
| Safety: | A deadly poison to humans by ingestion. Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits acrid fumes and irritating smoke. See also RICIN. Note: Do not confuse with abrine. |
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Chemistry
Water solubility: Dissolved in water
Form: Powder,mist,pellet
Color: Yellowish-white(Powdered)
Stable: Stable substance
Uses
Abrin (1393-62-0), which has some potential medical uses(such as in treatment to kill cancer cells) is not known to have been weaponised.The rosary pea is sometimes used as a herbal remedy and, which is the source of abrin, is common to many tropical areas throughout the world.Its seeds have been used to make beaded jewelry, which can lead to abrin poisoning if the seeds are chewed and swallowed. The outer shell of the seed protects the contents from the stomachs of most mammals.
Toxicity Data With Reference
| 1. | dni-mus-ast 50 µg/kg | TOXIA6 Toxicon. 11 (1973),379. | ||
| 2. | orl-hmn LDLo:7 µg/kg | MEIEDD Merck Index. 10 (1983),1. | ||
| 3. | orl-rat LDLo:300 mg/kg | AMIHAB AMA Archives of Industrial Health. 12 (1955),468. | ||
| 4. | orl-mus LD50:6638 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 21 (1971),888. | ||
| 5. | ipr-mus LD50:20 µg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds. 8 (1)(1982),107. | ||
| 6. | ivn-mus LD50:20 µg/kg | MEIEDD Merck Index. 10 (1983),1. | ||
| 7. | orl-rbt LDLo:21 mg/kg | AMIHAB AMA Archives of Industrial Health. 12 (1955),468. | ||
| 8. | orl-gpg LD50:299 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 21 (1971),888. |
Safety Profile
A deadly poison to humans by ingestion. Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits acrid fumes and irritating smoke. See also RICIN. Note: Do not confuse with abrine.
Specification
Abrin (1393-62-0),similar to ricin (a toxin that is found in the seeds of the castor oil plant), can last for a long time in the environment despite extreme conditions such as very hot or very cold temperatures.It is a natural poison that is found in the seeds of a plant called the rosary pea or jequirity pea.Abrin (1393-62-0) works by inhibiting cell protein synthesis and penetrating the cells of the body. By attaching to a carbohydrate chain on the cell surface, its molecule anchors itself to the cell and is subsequently engulfed and enters the inner parts of the cell where it reacts with a ribosomal subunit and interferes with the normal protein synthesis process of the cell. Without these proteins, cells cannot survive. This is harmful to the human body and may be fatal.
Within a few hours of inhaling significant amounts of Abrin (1393-62-0), the likely symptoms would be respiratory distress, nausea, cough, fever, and tightness in the chest. Heavy sweating may follow as well as pulmonary edema.And it would make breathing even more difficult, and also the skin might turn blue. Excess fluid in the lungs would be diagnosed by x-ray or by listening to the chest with a stethoscope. Finally, respiratory failure and low blood pressure may occur and at last leading to death.In the powder or mist form can cause redness and pain of the skin and the eyes. Death could take place within 36 to 72 hours of exposure, depending on the route of exposure and the dose received.
There is no antidote exists for abrin , so the most important factor is avoiding abrin exposure in the first place.The most important factor is getting the abrin off or out of the body as quickly as possible.And the types of supportive medical care would depend on several factors.