10029-09-1

Basic information

• Product Name: cis-1,4-Bis(aminomethyl)cyclohexane
• Synonyms: cis-1,4-Bis(aminomethyl)cyclohexane;cis-1,4-Bis(aminomethyl)cyclohexane
• CAS NO: 10029-09-1
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Mol File: 10029-09-1.mol

Chemical Properties

• Melting Point: -9°C(lit.)
• Boiling Point: 76°C/0.9mmHg(lit.)
• Flash Point: 119.7°C
• Appearance: /
• Density: 0.912g/cm³
• Refractive Index: 1.4940-1.4980
• CAS DataBase Reference: cis-1,4-Bis(aminomethyl)cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: cis-1,4-Bis(aminomethyl)cyclohexane(10029-09-1)
• EPA Substance Registry System: cis-1,4-Bis(aminomethyl)cyclohexane(10029-09-1)

Safety Data

• RIDADR: 2922
• HazardClass: 8/6.1
• PackingGroup: II
• Hazardous Substances Data: 10029-09-1(Hazardous Substances Data)

Usage

Uses

Used in Coatings Industry:
cis-1,4-Bis(aminomethyl)cyclohexane is used as a curing agent for epoxy resins in the production of coatings. It provides excellent mechanical, thermal, and chemical resistance properties, making the coatings suitable for a wide range of applications.
Used in Adhesives Industry:
cis-1,4-Bis(aminomethyl)cyclohexane is used as a curing agent for epoxy resins in the production of adhesives. Its properties enhance the adhesive's performance, making it suitable for bonding various materials in different industries.
Used in Composites Industry:
cis-1,4-Bis(aminomethyl)cyclohexane is used as a curing agent for epoxy resins in the manufacturing of composites. It imparts superior mechanical and thermal properties to the composites, making them ideal for use in aerospace, automotive, and construction applications.
Used as a Hardener for Polyurethanes:
cis-1,4-Bis(aminomethyl)cyclohexane is used as a hardener for polyurethanes, improving their mechanical and thermal properties. This makes the polyurethane materials suitable for various applications, including foams, elastomers, and coatings.
Used as a Crosslinking Agent for Advanced Polymer Materials:
cis-1,4-Bis(aminomethyl)cyclohexane acts as a crosslinking agent for advanced polymer materials, enhancing their performance characteristics such as mechanical strength, thermal stability, and chemical resistance.
Used in Pharmaceutical Industry:
cis-1,4-Bis(aminomethyl)cyclohexane has been investigated for its potential use in pharmaceuticals due to its unique structure and reactivity. It may be utilized as a building block for the synthesis of various pharmaceutical compounds.
Used in Organic Synthesis:
cis-1,4-Bis(aminomethyl)cyclohexane serves as a building block for organic synthesis, enabling the development of new organic compounds with diverse applications in various industries.

InChI:InChI=1S/C8H18N2/c9-5-7-1-2-8(6-10)4-3-7/h7-8H,1-6,9-10H2/t7-,8+

Upstream product

• 70924-83-3 cis-1,4-bis-acetylaminomethyl-cyclohexane 
• 2549-93-1 1,4-bis-(aminomethyl)cyclohexane 
• 619-81-8 cyclohexane-1,4-dicarboxylic acid 
• 6550-85-2 trans-1,4-cyclohexanedicarbonitrile 
• 10534-13-1 cyclohexane-1,4-dicarbonitrile 
• 70925-16-5 cis-cyclohexane-dicarboxylic acid-(1.4)-diamide 
• 6550-96-5 cis-cyclohexane-1,4-dicarbonitrile 
• 14571-47-2 (1s,4s)-cyclohexane-1,4-dicarbonyl dichloride 
• 619-81-8 cis-cyclohexane-1,4-dicarboxylic acid 

Downstream Products

• 854444-57-8 C-(4-methylene-cyclohexyl)-methylamine 
• 2680-24-2 cis-1,4-bis-benzaminomethyl-cyclohexane 
• 55778-73-9 N,N'-(cis-1,4-cyclohexylenebismethyl)-bis[2-hydroxydecylamine] 
• 59801-67-1 4,4'-cyclohexane-1,4-diyldimethyl-bis-thiomorpholine 1,1,1',1'-tetraoxide 
• 28282-16-8 C₂₄H₃₀N₂O₄ 
• 3245-36-1 N.N'-Di-<2-brom-benzyl>-cyclohexan-cis-1.4-bis-methylamin 
• 1312812-80-8 tert-butyl {[cis-4-({[(2-phenylquinolin-4-yl)carbonyl]amino}methyl)cyclohexyl]methyl}carbamate 
• 28057-26-3 N.N'-Di--cyclohexan-cis-1.4-bis-methylamin 
• 35873-81-5 3,3'-cis-cyclohexane-1,4-diyldimethyl-bis-oxazolidin-2-one 
• 1170-57-6 N_.N'-Dicyclohexanoyl-cyclohexan-cis-1.4-bis-methylamin 
• 2680-29-7 N.N'-Di-<2-fluor-benzyl>-cyclohexan-cis-1.4-bis-methylamin 
• 3056-83-5 N_.N'-Dibenzyl-cyclohexan-cis-1.4-bis-methylamin 
• 3056-91-5 N.N'-Di-<2-chlor-benzyl>-cyclohexan-cis-1.4-bis-methylamin 
• 35873-56-4 N,N'-cis-cyclohexane-1,4-diyldimethyl-bis-carbamic acid bis-(2-chloro-ethyl) ester 

Relevant articles and documents

METHOD FOR PRODUCING TRANS-BIS(AMINOMETHYL)CYCLOHEXANE, METHOD FOR PRODUCING BIS(ISOCYANATOMETHYL)CYCLOHEXANE, BIS(ISOCYANATOMETHYL)CYCLOHEXANE, POLYISOCYANATE COMPOSITION, AND POLYURETHANE RESIN

A method for producing trans-bis(aminomethyl)cyclohexane includes a trans-isomerization step in which cis-dicyanocyclohexane is isomerized into trans-dicyanocyclohexane by heating dicyanocyclohexane containing cis-dicyanocyclohexane in the presence of a t

METHOD FOR PRODUCING TRANS-1,4-BIS(AMINOMETHYL)CYCLOHEXANE

A method for producing trans-1,4-bis(aminomethyl)cyclohexane includes a nuclear hydrogenation step of producing a hydrogenated terephthalic acid or terephthalic acid derivative by nuclear hydrogenation of a terephthalic acid or terephthalic acid derivative, the terephthalic acid or terephthalic acid derivative being at least one selected from the group consisting of terephthalic acid, terephthalic acid ester, and terephthalic acid amide; a cyanation step of treating the hydrogenated terephthalic acid or terephthalic acid derivative with ammonia, thereby producing 1,4-dicyanocyclohexane, and producing trans-1,4-dicyanocyclohexane from the obtained 1,4-dicyanocyclohexane; and an aminomethylation step of treating the trays-1,4-dicyanocyclohexane with hydrogen, thereby producing trans-1,4-bis(aminomethyl)cyclohexane. Metal oxide is used as a catalyst in the cyanation step, and the obtained trans-1,4-dicyanocyclohexane has a metal content of 3000 ppm or less.

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Optimization led to compounds 33 and 37, which exhibit potent inhibition of human ACC2, 10-fold selectivity over inhibition of human ACC1, good physical and in vitro ADME properties and good bioavailability. X-ray crystallography has shown this series binding in the CT-domain of ACC2 and revealed two key hydrogen bonding interactions. Both 33 and 37 lower levels of hepatic malonyl-CoA in vivo in obese Zucker rats.