100701-49-3Relevant articles and documents
ENANTIOSELECTIVE SYNTHESIS OF MONOFLUORINATED MALONIC ACID MONOESTERS WITH ENZYMES OF MICROBAL ORIGIN
Kitazume, Tomoya,Sato, Takehiko,Ishikawa, Nobuo
, p. 1811 - 1814 (1984)
The optically active (+)- and (-)-2-fluoro-2-substituted malonic acid monoesters useful as the practical chiral synthon were obtained by the microbial hydrolysis of the corresponding malonic acid diesters with esterases or cellulases.
7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders
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Page/Page column 49, (2016/05/02)
The present invention relates to compounds and compositions of Formula P useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The definitions of variables A, B, R2, R3, R4, Ra, Ra′, Rb, Rb′, Rc, Rd, Rd′, Re, and Re′ are provided in the disclosure. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
A novel class of ion displacement ligands as antagonists of the αiIbβ3 receptor that limit conformational reorganization of the receptor
Jiang, Jian-Kang,McCoy, Joshua G.,Shen, Min,LeClair, Christopher A.,Huang, Wenwei,Negri, Ana,Li, Jihong,Blue, Robert,Harrington, Amanda Weil,Naini, Sarasija,David III, George,Choi, Won-Seok,Volpi, Elisabetta,Fernandez, Joseph,Babayeva, Mariana,Nedelman, Mark A.,Filizola, Marta,Coller, Barry S.,Thomas, Craig J.
supporting information, p. 1148 - 1153 (2014/03/21)
A collection of αIIbβ3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure-activity relationships, binding modality, and pharmacokinetic and pharmacodynamic
ORGANIC COMPOUNDS
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Paragraph 0109, (2013/07/31)
The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to a drug-eluting stent comprising said compounds and methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE
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Paragraph 0117, (2014/01/08)
[Problems to be Solved by the Invention] To provide a drug having excellent antibacterial activity against Gram-positive bacteria and Gram-negative bacteria and also being excellent in terms of safety. [Means for Solving the Problems] A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom m represents an integer 0, 1, or 2, n represents an integer 0 or 1 Ar1 represents a bicyclic heterocyclic group represented by the following formula: wherein Aa represents a nitrogen atom or C-Ra, Ab represents a nitrogen atom or C-Rb, and Ac represents a nitrogen atom or C-Rc, Ra, Rb, and Rc independently represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, R1 and R2 independently represent a hydrogen atom, an alkoxy group containing 1 to 6 carbon atoms, a halogenoalkoxy group containing 1 to 6 carbon atoms, a halogen atom, or a cyano group, Ar2 represents a bicyclic heterocyclic group represented by the following formulae:
Synthesis of analogues of porphobilinogen
Leeper, Finian J.,Rock, Martin,Appleton, Diana
, p. 2633 - 2642 (2007/10/03)
Syntheses are described of several analogues of porphobilinogen intended as substrates and/or inhibitors of porphobilinogen deaminase (hydroxymethylbilane synthase). 2-Methylporphobilinogen 12 has been synthesised from α-methylpyrrole 6, whereas a phosphonate analogue 20 of porphobilinogen, 8,9-didehydroporphobilinogen 26 and 9-fluoroporphobilinogen 38 have all been made from the 1H-pyrrolo[2,3-c]pyridine 14. The best route to 38 avoids fluoroacrylate 28 because of loss of fluorine during reduction of the double bond.
Microbial Approach to the Practical Monofluorinated Chiral Synthons
Kitazume, Tomoya,Sato, Takehiko,Kabayashi, Tadashi,Lin, Jenq Tain
, p. 1003 - 1006 (2007/10/02)
The synthetic approach to (+)- and (-)-2-fluoro-2-substituted malonic acid monoesters, based on the enantiotopic specificity of lipases and/or cellulases, which catalyze the stereospecific hydrolysis of the ester group in monofluorinated malonic acid dies
