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2-(1,3-thiazol-2-yl)acetonitrile is a chemical compound characterized by the molecular formula C5H4N2S. It presents as a white to light yellow solid and is recognized for its role in the synthesis of pharmaceuticals and agrochemicals. 2-(1,3-thiazol-2-yl)acetonitrile also serves as an intermediate in the production of dyes and in the manufacturing of polymers. Due to its hazardous nature, it is crucial to handle 2-(1,3-thiazol-2-yl)acetonitrile with care to prevent skin and eye irritation, and to avoid its harmful effects if ingested or inhaled.

101010-74-6

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101010-74-6 Usage

Uses

Used in Pharmaceutical Industry:
2-(1,3-thiazol-2-yl)acetonitrile is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of a wide range of medicinal compounds with potential applications in treating different diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(1,3-thiazol-2-yl)acetonitrile is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its involvement in the synthesis of these compounds helps in the development of effective solutions for crop protection and management of agricultural pests.
Used in Dye Production:
2-(1,3-thiazol-2-yl)acetonitrile is employed as an intermediate in the manufacturing process of dyes. Its chemical properties enable the creation of a diverse array of dyes with various color characteristics, which can be used in different industries, such as textiles, plastics, and printing inks.
Used in Polymer Manufacturing:
In the polymer industry, 2-(1,3-thiazol-2-yl)acetonitrile serves as a crucial intermediate in the synthesis of specific types of polymers. Its incorporation into the polymerization process can lead to the development of polymers with unique properties, such as enhanced stability, durability, or specific functional characteristics.
It is essential to adhere to proper safety measures during the storage and handling of 2-(1,3-thiazol-2-yl)acetonitrile to minimize the risk of skin and eye irritation, as well as to prevent potential harm from ingestion or inhalation.

Check Digit Verification of cas no

The CAS Registry Mumber 101010-74-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,0,1 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 101010-74:
(8*1)+(7*0)+(6*1)+(5*0)+(4*1)+(3*0)+(2*7)+(1*4)=36
36 % 10 = 6
So 101010-74-6 is a valid CAS Registry Number.

101010-74-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(1,3-thiazol-2-yl)acetonitrile

1.2 Other means of identification

Product number -
Other names thiazolylacetonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101010-74-6 SDS

101010-74-6Relevant articles and documents

Aryl imidazole derivative and application thereof

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Paragraph 0286-0289, (2021/06/23)

The invention relates to an aryl imidazole derivative and application thereof. The aryl imidazole derivative is a compound shown as a formula (I) in the description or pharmaceutically acceptable salt thereof. The invention also discloses application of the aryl imidazole derivative in preparation of drugs for treating cancers. The invention further discloses application of the aryl imidazole derivative in preparation of drugs for treating diseases caused by EGFR mutation.

CRYSTAL OF COMPOUND HAVING JAK-INHIBITING ACTIVITY

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Paragraph 0173, (2019/02/24)

An object of the present invention is to provide a compound with an excellent JAK1 inhibitory activity. The compound of the invention has JAK1 inhibitory activity, and thus, immunosuppressive effect, anti-inflammatory effect, anti-proliferative effect and so on, and is useful in the treatment of the diseases, for example, rheumatoid arthritis, inflammatory bowel disease, psoriasis, vasculitis, bronchial asthma, chronic obstructive pulmonary disease, eosinophilic sinusitis and nasal polyp.

INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF

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Paragraph 00542, (2018/07/05)

The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

PYRAZOLOTHIAZOLE COMPOUND AND MEDICINE

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Paragraph 0119, (2017/07/31)

The invention provides a pyrazolothiazole compound of the formula [I], or a pharmaceutically acceptable salt thereof: The compound of the invention has JAK1 inhibitory activity, and thus, immunosuppressive effect, anti-inflammatory effect and anti-proliferative effect, and is useful in the treatment of the diseases, for example, rheumatoid arthritis, inflammatory bowel disease, psoriasis and vasculitis, bronchial asthma, chronic obstructive pulmonary disease and eosinophilic sinusitis, nasal polyp.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

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Paragraph 0174 - 0175, (2014/05/24)

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

Discovery of novel quinolinone adenosine A2B antagonists

McGuinness, Brian F.,Ho, Koc-Kan,Stauffer, Tara M.,Rokosz, Laura L.,Mannava, Neelima,Kultgen, Steven G.,Saionz, Kurt,Klon, Anthony,Chen, Weiqing,Desai, Hema,Rogers, W. Lynn,Webb, Maria,Yin, Juxing,Jiang, Yan,Li, Tailong,Yan, Hao,Jing, Konghua,Zhang, Shengting,Majumdar, Kanak Kanti,Srivastava, Vikash,Saha, Samiran

scheme or table, p. 7414 - 7420 (2011/02/23)

A novel series of quinolinone-based adenosine A2B receptor antagonists was identified via high throughput screening of an encoded combinatorial compound collection. Synthesis and assay of a series of analogs highlighted essential structural features of the initial hit. Optimization resulted in an A2B antagonist (2i) which exhibited potent activity in a cAMP accumulation assay (5.1 nM) and an IL-8 release assay (0.4 nM).

Reactions of 2-Halothiazoles with Ketone Enolates and Nitrile Carbanions

Dillender, Samuel C.,Greenwood, Thomas D.,Hendi, Mukta S.,Wolfe, James F.

, p. 1184 - 1188 (2007/10/02)

Photostimulated reactions of 2-chlorothiazole (1a), 2-chloro-4-methylthiazole (1b), and 2-chloro-5-methylthiazole (1c) with pinacolone potassium enolate (2a) in liquid NH3 lead to formation of mono- and bis-2-thiazolyl ketones 3a-c and 4a-c via the SRN1 mechanism.A similar reaction with 2-bromothiazole (1d) gave 3a but no 4a.Reaction of 1a with 2a in the dark, or with the potassium enolate of diisopropyl ketone (2b) under near-UV irradiation or in the dark, does not result in chloride displacement.Instead, carbinols 5a-b, derived from initial ionization of H5 of 1a followed by aldol-type condensation of the resulting carbanion (11) with neutral ketone, are produced in good yields.Carbanion 11 can also be produced in synthetically useful concentrations by metalation of 1a with KNH2, n-BuLi, and LDA, with the latter base being most effective.Carbanions derived from acetonitrile, propionitrile, and phenylacetonitrile react smoothly with 1a in liquid NH3 to give the corresponding monosubstitution products resulting from chloride displacement.However, these reactions appear to proceed by an addition-elimination (SNAr) mechanism rather than an SRN1 process.

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