10169-50-3

Basic information

• Product Name: 5-Bromo-2-hydroxy-3-nitrobenzoic acid
• Synonyms: 5-Bromo-2-hydroxy-3-nitrobenzoic acid;C.I.10300;Salicyl Yellow A
• CAS NO: 10169-50-3
• Molecular Formula: C₇H₄BrNO₅
• Molecular Weight: 262.01
• Product Categories: Aromatic Building Blocks
• Mol File: 10169-50-3.mol

Chemical Properties

• Boiling Point: 346.6°C at 760 mmHg
• Flash Point: 163.4°C
• Appearance: /
• Density: 2.04g/cm³
• Vapor Pressure: 2.15E-05mmHg at 25°C
• Refractive Index: 1.693
• PKA: 1.62±0.20(Predicted)
• CAS DataBase Reference: 5-Bromo-2-hydroxy-3-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-hydroxy-3-nitrobenzoic acid(10169-50-3)
• EPA Substance Registry System: 5-Bromo-2-hydroxy-3-nitrobenzoic acid(10169-50-3)

Safety Data

• Hazardous Substances Data: 10169-50-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H4BrNO5/c8-3-1-4(7(11)12)6(10)5(2-3)9(13)14/h1-2,10H,(H,11,12)

Upstream product

• 89-55-4 5-bromosalicyclic acid 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 79427-99-9 sodium 3,5-dibromo-2-hydroxybenzoate 

Downstream Products

• 7693-52-9 4-bromo-2-nitrophenol 
• 124-38-9 carbon dioxide 
• 570-23-0 3-aminosalicylic acid 
• 773136-20-2 5-bromo-2-hydroxy-3-nitrobenzoic acid ethyl ester 
• 1440809-20-0 2-[3-(5-bromo-2-dimethylcarbamoylsulfanyl-3-nitrobenzyl)-2-oxo-2,3-dihydrobenzoimidazol-1-ylmethyl]pentanoic acid ethyl ester 
• 1090904-01-0 C₁₀H₁₁BrN₂O₄S 
• 1090904-00-9 5-bromo-2-dimethylcarbamoylsulfanyl-3-nitrobenzoic acid ethyl ester 
• 1090903-99-3 5-bromo-2-dimethylthiocarbamoyloxy-3-nitrobenzoic acid ethyl ester 

Relevant articles and documents

Rearrangements during nitrosodecarboxylation of isomeric dibromohydroxybenzoic acids

The reaction of 3,5-dibromo-4-hydroxybenzoic acid, its sodium salt, and also sodium 3,5-dibromo-2-hydroxybenzoate with NaNO2 in a glacial acetic acid at room temperature led to the formation of a mixture of dibromonitrophenol resulting from nitrosodecarboxylation accompanied by a rearrangement processes and followed by oxidation of the arising nitrosophenols.

Small-molecules that covalently react with a human prolyl hydroxylase-towards activity modulation and substrate capture

We describe covalently binding modulators of the activity of human prolyl hydroxylase domain 2 (PHD2) and studies towards a strategy for photocapture of PHD2 substrates. Reversible active site binding of electrophile bearing compounds enables susbsequent covalent reaction with a lysine residue (K408) in the flexible C-terminal region of PHD2 to give a modified protein that retains catalytic activity.

3-process for the preparation of amino-salicylic acid

The invention relates to a novel preparation method of 3-aminosalicylic acid. The novel preparation method is characterized in that a salicylic acid compound I as an initial raw material having a general formula shown in the description and a nitration agent undergo a reaction to produce a 3-nitrosalicylic acid compound II having a general formula shown in the description, and the 3-nitrosalicylic acid compound II undergoes nitryl catalytic hydrogenation reduction and dehalogenation hydrogenolysis reactions in the presence of an effective dose of a catalyst and hydrogen donors so that 3-aminosalicylic acid is produced.

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Chymase plays an important and diverse role in the homeostasis of a number of cardiovascular processes. Herein, we describe the identification of potent, selective chymase inhibitors, developed using fragment-based, structure-guided linking and optimizati