10237-77-1

Basic information

• Product Name: 3-HYDROXYPENTANOIC ACID
• Synonyms: 3-HYDROXYPENTANOIC ACID;3-Hydroxyvaleric acid;beta-hydroxyvaleric acid;3-Hydroxypentanoic acid, 98 %;rac-3-Hydroxypentanoic Acid;Pentanoicacid,3-hydroxy-
• CAS NO: 10237-77-1
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.13
• Mol File: 10237-77-1.mol

Chemical Properties

• Boiling Point: 253.3°Cat760mmHg
• Flash Point: 121.2°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0.00285mmHg at 25°C
• Refractive Index: 1.458
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-HYDROXYPENTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXYPENTANOIC ACID(10237-77-1)
• EPA Substance Registry System: 3-HYDROXYPENTANOIC ACID(10237-77-1)

Safety Data

• Hazardous Substances Data: 10237-77-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-HYDROXYPENTANOIC ACID is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique structure allows it to be a key component in the synthesis of drugs targeting specific medical conditions.
Used in Fine Chemical Industry:
3-HYDROXYPENTANOIC ACID is used as a synthetic intermediate for the production of fine chemicals. Its versatility in chemical reactions makes it an essential building block for creating specialty chemicals with specific applications in various markets.
Used in Diagnostics:
3-HYDROXYPENTANOIC ACID is used as a biomarker in the diagnosis of methylmalonic acidosis, a metabolic disorder. Its presence in the urine of affected patients helps in the identification and monitoring of the condition.

InChI:InChI=1/C5H10O3/c1-2-4(6)3-5(7)8/h4,6H,2-3H2,1H3,(H,7,8)

Upstream product

• 54074-85-0 ethyl-3-hydroxypentanoate 
• 141-82-2 malonic acid 
• 123-38-6 propionaldehyde 
• 94953-76-1 lithium α-lithioacetate 
• 15687-27-1 ibuprofen 
• 546-68-9 titanium(IV) isopropylate 
• 124-38-9 carbon dioxide 
• 5336-08-3 D-Ribono-1,4-lactone 
• 34371-14-7 2-deoxy-D-ribonolactone 
• 89448-49-7 3,5-O-Benzylidene-2-O-<(methylthio)thiocarbonyl>-D-ribonic Acid γ-Lactone 
• 89448-50-0 3,5-O-Benzylidene-2-deoxy-D-ribonic Acid γ-Lactone 
• 78138-89-3 2-Bromo-2-deoxy-D-arabinono-γ-lactone 
• 20603-44-5 3,5-O-Benzylidene-D-ribonic Acid γ-Lactone 
• 13991-37-2 trans-2-pentenoic acid 

Downstream Products

• 124-38-9 carbon dioxide 
• 7732-18-5 water 
• 802294-64-0 propionic acid 
• 10191-25-0 3-oxo-valeric acid 
• 626-98-2 pent-2-enoic acid 
• 5204-64-8 3-pentenoic acid 

Relevant articles and documents

Abnormal metabolites of isoleucine in a patient with propionyl-CoA carboxylase deficiency

A number of previously unrecognized abnormal metabolites have been identified and quantitated in the urine of a patient with an inherited deficiency of propionyl CoA carboxylase. These included the isoleucine metabolites 2 methyl 3 hydroxybutyric acid and 2 methylacetoacetic acid. The isomers 3 hydroxyvaleric acid and 3 oxovaleric acid were found, which may be products of the condensation of propionyl CoA with acetyl CoA catalyzed by 3 oxoacyl CoA thiolases. Following a load of isoleucine, 2 methylbutyrylglycine was identified. This metabolite has not previously been observed in man.

Photolysis and photocatalysis of ibuprofen in aqueous medium: Characterization of by-products via liquid chromatography coupled to high-resolution mass spectrometry and assessment of their toxicities against Artemia Salina

The degradation of the pharmaceutical compound ibuprofen (IBP) in aqueous solution induced by direct photolysis (UV-A and UV-C radiation) and photocatalysis (TiO2/UV-A and TiO2/UV-C systems) was evaluated. Initially, we observed that whereas photocatalysis (both systems) and direct photolysis with UV-C radiation were able to cause an almost complete removal of IBP, the mineralization rates achieved for all the photodegradation processes were much smaller (the highest value being obtained for the TiO 2/UV-C system: 37.7%), even after an exposure time as long as 120 min. Chemical structures for the by-products formed under these oxidative conditions (11 of them were detected) were proposed based on the data from liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) analyses. Taking into account these results, an unprecedented route for the photodegradation of IBP could thus be proposed. Moreover, a fortunate result was achieved herein: tests against Artemia salina showed that the degradation products had no higher ecotoxicities than IBP, which possibly indicates that the photocatalytic (TiO2/UV-A and TiO2/UV-C systems) and photolytic (UV-C radiation) processes can be conveniently employed to deplete IBP in aqueous media. Copyright

A study of the reaction of n-BuLi with Ti(Oi-Pr)4 as a method to generate titanacyclopropane and titanacyclopropene species

The use of the combination of reagents Ti(Oi-Pr)4/n-BuLi, introduced by the group of J.J. Eisch in 2001, has only found a few applications so far, with sometimes conflicting observations. This article describes a study aimed at clarifying the nature, the stability and the reactivity of the active organometallic species involved. Reactions with CO2 and other trapping reagents reveal that it is generated within a few minutes at 0 C in THF, where it can be considered to be stable for 30 min. Most of our results are consistent with the expected titanacyclopropane nature of this reagent but some observations suggest that the chemistry at play may be more complicated.

PHA E and PHA C components of poly(hydroxy fatty acid) synthase from thiocapsa pfennigii

PCT No. PCT/DE95/01279 Sec. 371 Date Jul. 3, 1997 Sec. 102(e) Date Jul. 3, 1997 PCT Filed Sep. 15, 1995 PCT Pub. No. WO96/08566 PCT Pub. Date Mar. 21, 1996The present invention relates to a process for the production of poly (hydroxy fatty acids) as well as recombinant bacterial strains for carrying out the process. In addition, new poly(hydroxy fatty acids) and new substrates for the production of conventional and new poly(hydroxy fatty acids) are described. Moreover, the invention also relates to a DNA fragment, which codes for a PhaE and a PhaC component of the poly(hydroxy fatty acid) synthase from Thiocapsa pfennigii, as well as the corresponding poly (hydroxy fatty acid) synthase protein.

Process for production of N-acyl-α-amino acids

A process for the production of an N-acyl-α-amino acid represented by the general formula STR1 wherein R1, R2, R3 and R4, independently from each other, represent a hydrogen atom, an alkyl or cycloalkyl group which may be substituted, or an aryl or heteroaromatic group selected from the group consisting of furyl, pyrrolyl, pyridinyl, thienyl and indolyl which may be substituted, which comprises reacting an oxirane represented by the general formula STR2 wherein R1 and R2 are as defined above, an amide compound represented by the general formula wherein R3 and R4 are as defined above, and carbon monoxide in the presence of hydrogen, a cobalt-containing catalyst, and a promoter composed of a compound containing a metal selected from Groups I, II, III and IV of the periodic table.