10264-09-2

Basic information

• Product Name: N-butyl-2-phenylacetamide
• Synonyms: benzeneacetamide, N-butyl-; N-Butyl-2-phenylacetamide
• CAS NO: 10264-09-2
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.2695
• Mol File: 10264-09-2.mol

Chemical Properties

• Boiling Point: 363.4°C at 760 mmHg
• Flash Point: 217.3°C
• Density: 0.984g/cm³
• Vapor Pressure: 1.81E-05mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: N-butyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-butyl-2-phenylacetamide(10264-09-2)
• EPA Substance Registry System: N-butyl-2-phenylacetamide(10264-09-2)

Safety Data

• Hazardous Substances Data: 10264-09-2(Hazardous Substances Data)

Upstream product

• 101-97-3 Ethyl 2-phenylethanoate 
• 109-73-9 N-butylamine 
• 103-82-2 phenylacetic acid 
• 4254-93-7 tris-butylamino-borane 
• 937-39-3 2-phenylacetylhydrazine 
• 1666-13-3 diphenyl diselenide 
• 144809-66-5 1-<(N-Butyl-N-(phenylacetyl)carbamoyl)oxy>-2(1H)-pyridinethione 
• 109-65-9 1-bromo-butane 
• 103-81-1 Benzeneacetamide 
• 88410-05-3 (Z)-β-bromo-β-fluorostyrene 
• 7732-18-5 water 
• 103-80-0 phenylacetyl chloride 
• 51463-66-2 dimethyl (2-phenylacetyl)phosphonate 
• 13504-37-5 diethyl phenylacetylphosphonate 

Downstream Products

• 36910-81-3 N-Butyl-N-trimethylsilyl-phenylacetamid 
• 104515-37-9 2-Phenyl-pent-4-enoic acid butylamide 
• 29175-09-5 C₁₃H₁₆ClNO₂ 
• 144809-66-5 1-<(N-Butyl-N-(phenylacetyl)carbamoyl)oxy>-2(1H)-pyridinethione 
• 104515-39-1 3-Phenyl-5-phenylselanylmethyl-tetrahydro-furan-2-ol 
• 104515-38-0 Butyl-[3-phenyl-5-phenylselanylmethyl-dihydro-furan-(2E)-ylidene]-amine 
• 23068-45-3 N-Butyl-2-phenylethylamine 
• 1207269-20-2 3-benzyl-4-n-butyl-1-(4-trifluoromethyl)phenyl-1H-1,2,4-triazole-5(4H)-one 
• 1207269-21-3 3-(1'-bromo-benzyl)-4-n-butyl-1-(4-trifluoromethyl)phenyl-1H-1,2,4-triazole-5(4H)-one 
• 1207268-95-8 ethyl 2,2-dimethyl-2-(3-methyl-4-(1-(2-(4-n-butyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzylthio)-phenoxy)-acetate 
• 1207268-96-9 ethyl 2-(2,5-dimethyl-4-(1-(3-(4-n-butyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzylthio)-phenoxy)-acetate 
• 1207269-19-9 N-n-butyl-2-phenyl-N-(4-trifluoromethyl)phenylacetamide hydrazone 
• 5070-32-6 N-n-butyl-2-oxo-2-phenylacetamide 
• 60-12-8 2-phenylethanol 

Relevant articles and documents

Efficient procedure for the preparation of amides using polymer-bound reagents

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The Selective N-Monoalkylation of Amides with Alkyl Halides in the Presence of Alumina and KOH

The effects of alumina impregnated with KOH (KOH/Al2O3) and a mixture of alumina and powdered KOH (KOH+Al2O3) have been examined using the alkylation of benzamide under various conditions.In each case, alkylation occurs exclusively in the pores of the alumina, the extent depending upon the alumina-pore size.For both yield and selectivity for N-monoalkylation, KOH+Al2O3 is superior to KOH/Al2O3.Dioxane is the best of the solvents employed.It is proposed that, in dioxane, an enolate-like species, PhC(O-K+)=NR', exists as stable ion pair aggregates, which are true reactants in the pore.This method, using KOH/Al2O3 or KOH+Al2O3, has been applied to N-alkylation of the other amides, giving the N-monoalkylated products in substantial yields with extremely high selectivities. 2-Phenylacetamide is regioselectively N-monoalkylated in high yields.This regioselectivity is explained in terms of steric hindrance.

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