103577-65-7

Basic information

• Product Name: [4-(2,2,2-Trifluoro-ethoxy)-pyridin-2-yl]-methanol
• Synonyms: [4-(2,2,2-Trifluoro-ethoxy)-pyridin-2-yl]-methanol
• CAS NO: 103577-65-7
• Molecular Formula: C₈H₈F₃NO₂
• Molecular Weight: 207.15
• Mol File: 103577-65-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: [4-(2,2,2-Trifluoro-ethoxy)-pyridin-2-yl]-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(2,2,2-Trifluoro-ethoxy)-pyridin-2-yl]-methanol(103577-65-7)
• EPA Substance Registry System: [4-(2,2,2-Trifluoro-ethoxy)-pyridin-2-yl]-methanol(103577-65-7)

Safety Data

• Hazardous Substances Data: 103577-65-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
TFPM is used as a building block in organic synthesis for its ability to contribute to the formation of complex organic compounds, enhancing the diversity and functionality of synthesized products.
Used in Pharmaceutical Research:
In pharmaceutical research, TFPM is utilized as a ligand for metal catalysts, which is instrumental in facilitating various chemical reactions essential for the development of new pharmaceuticals.
Used in the Development of New Materials:
TFPM is employed in the development of new materials due to its unique properties that can be integrated into the design and synthesis of advanced materials with specific applications.
Used in the Production of Fine Chemicals:
TFPM is used in the production of fine chemicals, where its reactivity and structural features are leveraged to create high-quality specialty chemicals for various industries.
Used in Chemical Compound Preparation:
TFPM is used as a reagent in the preparation of various organic compounds, contributing to the synthesis of molecules with potential applications in different fields, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 98197-88-7 4-nitro-2-(hydroxymethyl)pyridine 
• 75-89-8 2,2,2-trifluoroethanol 
• 420-87-1 sodium 2,2,2-trifluoroethanolate 
• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 103577-58-8 2-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridine 1-oxide 

Relevant articles and documents

ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS

Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided.

2--1H-thienoimidazoles. A Novel Class of Gastric H+/K+-ATPase Inhibitors

2-thienoimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase.The isomers of the two possible thienoimidazole series were found to be potent inhibitors of gastric acid secretion in vitro and in vivo.Structure-activity relationships indicate that especially lipophilic alkoxy, benzyloxy, and phenoxy substituents with additional electron-demanding properties in the 4-position of the pyridine moiety combined with an unsubstituted thienoimidazole lead to highly active compounds with a favorable chemical stability.Various substitution patterns in the thienoimidazole moiety result in lower biological activity.The heptafluorobutyloxy derivative saviprazole (HOE 731, 5d) was selected for further development and is currently undergoing clinical evaluation.Comprehensive pharmacological studies indicate a pharmacodynamic profile different to omeprazole, the first H+/K+-ATPase blocker introduced on the market.