10374-28-4

Basic information

• Product Name: N,N-diethylcyclopropanecarboxaMide
• Synonyms: N,N-diethylcyclopropanecarboxaMide
• CAS NO: 10374-28-4
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.2108
• Mol File: 10374-28-4.mol

Chemical Properties

• Boiling Point: 224.1±7.0 °C(Predicted)
• Appearance: /
• Density: 0.999±0.06 g/cm3(Predicted)
• PKA: -0.47±0.20(Predicted)
• CAS DataBase Reference: N,N-diethylcyclopropanecarboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethylcyclopropanecarboxaMide(10374-28-4)
• EPA Substance Registry System: N,N-diethylcyclopropanecarboxaMide(10374-28-4)

Safety Data

• Hazardous Substances Data: 10374-28-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N,N-diethylcyclopropanecarboxamide is used as a base structure for the synthesis of complex compounds, which can be further utilized in the development of pharmaceutical products. Its cyclic nature allows for the creation of diverse molecules with potential therapeutic applications.
Used in Chemical Synthesis:
N,N-diethylcyclopropanecarboxamide is used as a starting material or intermediate in the synthesis of other complex organic compounds. Its unique structure enables the formation of various chemical bonds, making it a versatile component in the production of specialty chemicals.
Used in Research and Development:
N,N-diethylcyclopropanecarboxamide is employed as a research compound in academic and industrial laboratories. Its properties and reactivity are studied to understand its potential applications and to develop new synthetic methods for creating novel compounds.
It is important to handle N,N-diethylcyclopropanecarboxamide with care due to its chemical characteristics, ensuring safety and proper utilization in the intended applications.

Upstream product

• 109-89-7 diethylamine 
• 1759-53-1 cyclopropanecarboxylic acid 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 54947-39-6 cyclopropanecarboxylic acid n-butyl ester 

Downstream Products

• 467426-68-2 (±)-(cis)-2-iodocyclopropyl-N,N-diethylcarboxamide 
• 5617-96-9 N-(cyclopropylmethyl)-N-ethylethanamine 
• 2759-52-6 N-phenylcyclopropanecarboxamide 
• 150322-73-9 1-cyclopropyl-2-(2-fluorophenyl)ethanone 
• 467426-60-4 1-methyl-cyclopropanecarboxylic acid diethylamide 

Relevant articles and documents

Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids

Cardiolipin (CL) is a phospholipid located in both the eukaryotic mitochondrial inner membrane and the bacterial cell membrane. Some bacterial CLs are known to contain cyclopropane moieties in their acyl chains. Although the CLs are thought to be involved in the innate immune response, there have been few attempts at chemical synthesis of the CLs, and detailed studies of their biological activities are scarce. Thus, we have developed a synthetic route to CLs containing chiral cyclopropane moieties.

Process development on an efficient new convergent formal synthesis of MIV-150

Starting from a known linear route and a proposed convergent route, we have successfully developed a new hybrid convergent route to MIV-150 that takes advantage of the robust chemistry for the preparation of a fluoroketal and the stereospecific Negishi coupling of an iodocyclopropane moiety to a benzene ring. Stereoselective β- and cis-iodination chemistry was developed for the preparation of an enantiomerically pure iodocyclopropanecarboxylate. Following the Negishi coupling, proven chemistry from the linear route was incorporated, thus ensuring a similar high-purity profile for the final active pharmaceutical ingredient (API). In addition, we have prepared and evaluated a series of basic inorganic and organic MIV-150 salts that have drastically increased water solubility over the parent compound.

Ni-Al Bimetallic Catalyzed Enantioselective Cycloaddition of Cyclopropyl Carboxamide with Alkyne

A Ni-Al bimetallic catalyzed enantioselective cycloaddition reaction of cyclopropyl carboxamides with alkynes has been developed. A series of cyclopentenyl carboxamides were obtained in up to 99% yield and 94% ee. The bifunctional-ligand-enabled bimetallic catalysis proved to be an efficient strategy for the C-C bond cleavage of unreactive cyclopropanes.

PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATES

The invention relates to a process for the preparation of cyclopropyl benzyl ketone compounds of formula (II) wherein R1 represents fluorine or chlorine atom or C1-4 alkoxy group, by the reaction of a Grignard reagent, obtained from the reaction of compound of formula (V), wherein X represents chlorine or fluorine atom, with the compound of formula (IV), wherein R2 represents C1-4 alkyl group, having a straight or branched chain. The process can be applied preferably on industrial scale. Compound of formula (II), wherein R represents a fluorine atom in position 2 is an intermediate of the preparation process of prasugrel, which is a platelet inhibitor used in the therapy.