104961-64-0

Basic information

• Product Name: 3-(pyridin-2-ylamino)propanoic acid
• Synonyms: 3-(pyridin-2-ylamino)propanoic acid;N-2-Pyridinyl-β-alanine;3-(2-Pyridinylamino)propionic acid;N-2-Pyridinyl-beta-alanine;3-Pyridine-2yl-Amino Propionic acid
• CAS NO: 104961-64-0
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.1772
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 104961-64-0.mol

Chemical Properties

• Melting Point: 139℃
• Boiling Point: 389.434°C at 760 mmHg
• Flash Point: 189.323°C
• Appearance: /
• Density: 1.280
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Methanol
• PKA: 4.21±0.10(Predicted)
• CAS DataBase Reference: 3-(pyridin-2-ylamino)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(pyridin-2-ylamino)propanoic acid(104961-64-0)
• EPA Substance Registry System: 3-(pyridin-2-ylamino)propanoic acid(104961-64-0)

Safety Data

• Hazardous Substances Data: 104961-64-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(pyridin-2-ylamino)propanoic acid is used as an intermediate in the synthesis of Dabigatran etexilate derivatives. Dabigatran etexilate is an oral direct thrombin inhibitor used for the prevention and treatment of various thromboembolic disorders.
Used in Preparation of E925620:
3-(pyridin-2-ylamino)propanoic acid is also used in the preparation of the acid form of E925620, which is a drug candidate with potential therapeutic applications.

InChI:InChI=1/C8H10N2O2/c11-8(12)4-6-10-7-3-1-2-5-9-7/h1-3,5H,4,6H2,(H,9,10)(H,11,12)

Upstream product

• 55364-85-7 methyl ester of N-(2-pyridyl)-β-alanine 
• 50342-32-0 3-(pyridin-2-ylamino)propanenitrile 
• 504-29-0 2-aminopyridine 
• 98594-22-0 3-[2]pyridylamino-propionaldehyde oxime 
• 142-08-5 2-hydroxypyridin 
• 107-95-9 3-amino propanoic acid 
• 141-32-2 acrylic acid n-butyl ester 
• 79-10-7 acrylic acid 

Downstream Products

• 19068-80-5 3-(pyridin-2-ylamino)propan-1-ol 
• 101935-20-0 N-[2]pyridyl-β-alanine amide 
• 103041-38-9 2-chloromethyl-1-methyl-1H-benzimidazole-5 ethyl acetate 
• 676515-33-6 2,3-dihydro-1,8-naphthyridin-4(1H)-one 

Relevant articles and documents

PYRANOPYRAZOLE AND PYRAZOLOPYRIDINE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: (I), (II) These compounds inhibit Coagulation Factor Xlla in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.

REACTION OF 2-AMINOPYRIDINES WITH α,β-UNSATURATED ACIDS

The reaction of 2-amino- and 2-amino-5-halopyridines with acrylic, methacrylic, and crotonic acids forms N-(2-pyridyl)- and N-(5-halo-2-pyridyl)-β-alanines and the betaines 2-amino-1-(2-carboxylatoethyl)pyridinium or 3,4-dihydropyridopyrimidin-2-ones, or their homologs.

Synthesis and characterization of lanthanon(III) chelates of ligands possessing N,N,O donors

Schiff bases derived from the condensation of α-pyridone with anthranilic acid and β-alanine and their lanthanon(III) chelates have been synthesised and characterised by physicochemical techniques.Potentiometric studies have been carried out by Irving-Rossotti method in 30percent (v/v) dioxane-water media (μ-0.01 M, 0.05 M and 0.10 M NaClO4) at 25 deg, 35 deg, and 45 deg. ΔG0, ΔH0 and ΔS0 of the metal chelates have been also evaluated.