105738-24-7

Basic information

• Product Name: CHLORO-ACETIC ACID 4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER
• Synonyms: OTAVA-BB BB0115090583;AURORA 23329;CHLORO-ACETIC ACID 4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER;AKOS BC-3023;4-methyl-2-oxo-2H-chromen-7-yl chloroacetate;acetic acid, chloro-, 4-methyl-2-oxo-2H-1-benzopyran-7-yl;(4-methyl-2-oxo-chromen-7-yl) 2-chloroacetate;(4-methyl-2-oxochromen-7-yl) 2-chloroacetate
• CAS NO: 105738-24-7
• Molecular Formula: C₁₂H₉ClO₄
• Molecular Weight: 252.65
• Mol File: 105738-24-7.mol

Chemical Properties

• Boiling Point: 404.8°C at 760 mmHg
• Flash Point: 175.6°C
• Appearance: /
• Density: 1.372g/cm³
• Vapor Pressure: 9.21E-07mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: CHLORO-ACETIC ACID 4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: CHLORO-ACETIC ACID 4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER(105738-24-7)
• EPA Substance Registry System: CHLORO-ACETIC ACID 4-METHYL-2-OXO-2H-CHROMEN-7-YL ESTER(105738-24-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 105738-24-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H9ClO4/c1-7-4-11(14)17-10-5-8(2-3-9(7)10)16-12(15)6-13/h2-5H,6H2,1H3

Upstream product

• 108-46-3 recorcinol 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 182115-37-3 2-oxo-2H-chromen-7-yl chloroethanoate 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 182115-42-0 dihydrofuro[2,3-h]coumarin-9-one 
• 93353-47-0 4-methyldihydrofuro[2,3-h]coumarin-9-one 
• 50690-12-5 2-chloro-1-(2,4,6-trimethyl-phenyl)-ethanone 
• 2623-45-2 2-chloro-1-(2,4-dimethyl-phenyl)-ethanone 
• 397874-72-5 9-hydroxy-4-methyl-furo[2,3-h]chromen-2-one 

Relevant articles and documents

A fluorescent chemosensor for relay recognition of Fe3+ and PO43? in aqueous solution and its applications

A novel fluorescent probe XDS based on 4-methylumbelliferone and 2-picolylamine platforms has been designed and synthesized, which behaves fast relay recognition of Fe3+ and PO43? via a fluorescence “on?off?on” response signal. Probe XDS exhibited very high sensitivity and unique selectivity for Fe3+ over other common metal ions, and the detection limit of was 3.2 × 10?7 M. Moreover, the addition of the PO43? ions could cause the recovery of fluorescence. This relay recognition feature of probe XDS has potential applications in the determination of trace amount of Fe3+ and PO43? in environmental systems. Interestingly, fluorescence imaging experiments demonstrated that the probe XDS can also be used to monitoring the intracellular Fe3+ in RAMOS cells.

Benzocoumarin chalcone neuraminidase inhibitor and preparation method and application thereof

The invention relates to the technical field of biological medicines. The invention relates to a benzocoumarin chalcone neuraminidase inhibitor and a preparation method and application thereof, and the inhibitor has a structure shown as a formula I. The compound is novel in structure, and experiments show that the compound has good neuraminidase inhibition activity and is expected to be used for preparing medicines for inhibiting neuraminidase activity.

Coumarin-based relay responsive fluorescent molecular probe and preparation method and application thereof

The invention relates to a coumarin-based relay responsive fluorescent molecular probe and a preparation method and an application thereof and belongs to the technical field of fluorescent chemical sensing materials. The preparation method comprises the following steps of: by taking 4-methylum-belliferyl as a fluorescent group, substituting hydroxyl hydrogen on a site C-7 on 4-methylum-belliferyl by chloroacetyl chloride to form an intermediate compound R; and then performing a substituting reaction on the compound R and 2-methyl pyridinamine as well to combine to prepare the fluorescent molecular probe material. The fluorescent molecular probe prepared by the method has strong blue fluorescent emission. Charge distribution of the probe molecular structure is changed in the presence of Fe. The blue fluorescence is quenched. After further adding phosphate anions, the fluorescence of the probe is recovered by means of the supplementary effect of metal ions and negative charges, so that the relay identifying detection on Fe3 and phosphate anions in a same system is realized, detection and recognition under 100% water soluble condition are realized, and change of the fluorescent signal is macroscopic.

Synthesis and convenient functionalisation of pyridazinofurocoumarins: Nitrogenated isosters of potent DNA inhibitors

Pyridazino[3,4-h]psoralens and pyridazino[3,4-j]angelicins are prepared in good yield from resorcinols through a direct, easy and generally applicable synthetic route. The key step in this route is the inverse electron-demand Diels-Alder reaction between linear or angular furocoumarins and 3,6-bis(methoxycarbonyl)-1,2,4,5-tetrazine to give the dicarboxymethylated tetracycles. The ester group in the peri position with respect to the oxygen in the furan ring can be regioselectively transformed to give primary or secondary amides. Similarly, the two ester groups in the tetracycle can be transformed in a high-efficiency process to give bis-amides that can be either symmetrical (from the same amine) or unsymmetrical (from two different amines).

Intermolecular character of the Fris rearrangement in the series of acyloxycoumarins

In the study of the Fris rearrangement in the series of 7-and 4-acyloxycoumarins we obtained certain data indicating intermolecular character of the rearrangement. The Fris rearrangement of a mixture of 7-benzoyloxy-4-metylcoumarin and 7-acetoxycoumarin results in formation of four reaction products in approximately equal molar ratio. Also, four products were obtained in the Fris rearrangement of 7-and 4-acyloxycoumarins in the presence of hydroxycoumarins. The Fris rearrangement of acyloxycoumarins in the presence of m-xylene at acylcoumarin-m-xylene ratio of 1:6 leads to the corresponding hydroxycoumarins and acylated m-xylenes. Intermediate formation of acylium ions was also detected by evolution of carbon monooxide at the Fris rearrangement of 7-pyvaloyloxy-and 7-isobutyryloxy-4-methylcoumarins. A product of intermolecular migration, 3-acetyl-4-hydoxy-6-methylcoumarin, was discovered also in the rearrangement of 4-acetoxycoumarin in the presence of 4-hydoxy-6-methylcoumarin catalyzed by phosphorus oxychloride.