106447-44-3Relevant articles and documents
A refining method of Cefprozil (by machine translation)
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Paragraph 0020; 0033; 0035, (2018/05/30)
The invention relates to a kind of Cefprozil refining method, including Cefprozil crude synthesis and Cefprozil refining, wherein the refining comprises: 1) will Cefprozil crude product in adding ethanol, stirring, dilute hydrochloric acid aqueous solution to adjust the pH to 2.0 - 2.2, stirring, dissolving crude product, filtering, to obtain the Cefprozil salt of the crude solution; 2) the above-mentioned solution adds by drops to 4% sodium bicarbonate solution, adjusting the pH to 4.6 - 5.0, cooling, thermal insulation mixing, filtering, washing, and a ground line, to get the solid; 3) step 2) the resulting solid dissolved in water, adding activated carbon, heating to 30 - 35 °C, fully stirring, after filtering the filtrate, the filtrate is cooled to 0 - 5 °C, added to the mixed solvent, crystallization, control the temperature and the stirring speed brilliantly 1.5 h, filtering, washing, and a ground line, vacuum drying, spore propylene pure product. The present invention provides a refined method has the simple conditions, cis-isomer content high, high purity and the like. (by machine translation)
Synthetic method of cefprozil
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Paragraph 0020; 0029; 0031; 0033; 0039; 0045; 0051, (2018/05/30)
The invention relates to a synthetic method of cefprozil. The synthetic method comprises the following steps: iodination reaction and Wittig reaction are performed on 7-ACA as a starting material after silylation protection, and a compound 2 is generated; a compound 1, namely, the target product cefprozil is generated from the compound 2 and methyl D-(-)-4-hydroxy-phenylglycinate under catalysis of AlMe3. The conversion rate is high, the process is simple, the cis-isomer content is high, and the synthetic method is suitable for large-scale industrial production.
A 7 - amino - 3 - propylene - 1 - yl - 3 - cephem - 4 - carboxylic acid synthesizing method
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Paragraph 0039; 0040; 0044; 0045; 0049; 0050; 0054; 0055, (2017/07/04)
The invention relates to a synthesis method of high-purity 7-amino-3-propylene-1-yl-3-cephem-4-carboxylic acid. The method takes deacetylated-7-aminocephalosporanic acid (D-7-ACA) as a starting raw material, and the starting raw material is reacted with ethyltriphenyl phosphonium bromide through oxidization to generate the 7-amino-3-propylene-1-yl-3-cephem-4-carboxylic acid. The synthesis method has a simple process, low cost and high product yield; the purity is more than 99% and the synthesis method is suitable for industrial production.
PROCESSES FOR THE PREPARATION OF CEPHEM DERIVATIVES
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Page/Page column 18, (2008/06/13)
Provided is a process for preparing a compound of formula 1 or its salt, which includes reacting a compound of formula 2 with a compound of formula 3 in the presence of a base.
PROCESSES FOR THE PREPARATION OF CEPHALOSPORIN DERIVATIVES
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Page/Page column 7-8, (2008/06/13)
Provided is a process for preparing a compound of formula 1 or its salt. The process includes reacting a compound of formula 4 with acetaldehyde in a mixed solvent including water, isopropanol, and methylenechloride in a volume ratio of 1:3-6:11-14 in the
PROCESS FOR THE PREPARATION OF (Z)-ISOMER ENRICHED 7-AMINO-3-PROPEN-1-YL-3-CEPHEM-4- CARBOXYLIC ACID
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Page 12, (2010/02/06)
The invention relates to a process for enrichment of the (Z)-isomer amount in a mixture of the (Z)- and (E)- isomers of 7-amino-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid.