107752-93-2

Basic information

• Product Name: ethyl 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate
• Synonyms: ethyl 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate
• CAS NO: 107752-93-2
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.40092
• Mol File: 107752-93-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate(107752-93-2)
• EPA Substance Registry System: ethyl 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate(107752-93-2)

Safety Data

• Hazardous Substances Data: 107752-93-2(Hazardous Substances Data)

Upstream product

• 2025-40-3 ethyl benzylidenecyanoacetate 
• 126-81-8 dimedone 
• 2169-69-9 ethyl (E)-2-cyano-3-phenyl-2-propenoate 
• 31771-33-2 2-phenyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine 
• 3471-13-4 dimedone 
• 105-56-6 ethyl 2-cyanoacetate 
• 100-52-7 benzaldehyde 
• 105-34-0 methyl 2-cyanoacetate 

Downstream Products

• 1360189-13-4 ethyl 2-(4-methoxybenzamido)-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate 
• 1360189-10-1 ethyl 2-(4-bromobenzamido)-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate 
• 1360189-09-8 ethyl 2-benzamido-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate 
• 1360189-08-7 ethyl 2-acetamido-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate 
• 1227407-84-2 2,8,8-trimethyl-5-phenyl-5,7,8,9-tetrahydro-4H,6H-chromeno[2,3-d][1,3]oxazine-4,6-dione 
• 1227407-89-7 ethyl 2-(diacetylamino)-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate 

Relevant articles and documents

Diammonium hydrogen phosphate: An efficient and versatile catalyst for the one-pot synthesis of tetrahydrobenzo[b]pyran derivatives in aqueous media

Diammonium hydrogen phosphate was used as a mild, efficient, neutral, and cheap catalyst for the synthesis of various 4H-benzo[b]pyran derivatives via a one-pot, three-component condensation of aromatic aldehydes, active methylene compounds, and dimedone in aqueous media. Copyright Taylor & Francis Group, LLC.

Ag3[PMo12O40]: An efficient and green catalyst for the synthesis of highly functionalized pyran-annulated heterocycles via multicomponent reaction

A facile, efficient and eco-friendly catalytic protocol was developed for the synthesis of medicinally important pyran-annulated heterocycles via multicomponent reaction (MCR). Cyclocondensation of differently substituted aromatic aldehydes, malononitrile

(S)-proline as a neutral and efficient catalyst for the one-pot synthesis of tetrahydrobenzo[b]pyran derivatives in aqueous media

(S)-Proline has been used as a mild, efficient and neutral catalyst for synthesis of various 4H-benzo[b]pyran derivatives via a one-pot three-component condensation of aromatic aldehydes, active methylene compounds, and dimedone in aqueous media. This method offers the advantages of proceeding and neutral and mild conditions, giving high to excellent yields of the products and simple workup. Georg Thieme Verlag Stuttgart.

Sodium bromide catalysed one-pot synthesis of tetrahydrobenzo[b]pyrans via a three-component cyclocondensation under microwave irradiation and solvent free conditions

Sodium bromide catalysed three-component cyclocondensation of aryl aldehydes, alkyl nitriles and dimedone proceeds under microwave irradiation in solvent free conditions to give highly functionalised tetrahydrobenzo[b]pyrans in excellent yields.

One-pot synthesis of 2-amino-4-aryl-3-carbalkoxy-7,7-dimethyl-5,6,7,8- tetrahydrobenzo[b]pyran derivatives catalyzed by KF/basic Al2O 3 under ultrasound irradiation

Synthesis of 2-amino-4-aryl-3-carbalkoxy-7,7-dimethyl-5-oxo-5,6,7,8- tertrahydrobenzo[b]pyran derivatives was carried out in 81-98% yields by one-pot condensation of aromatic aldehydes with cyanoacetic esters and 5,5-dimethyl-1,3-cyclohexanedione catalyze

A convenient synthesis of 2-amino-5,6,7,8,-tetrahydro-5-oxo-4-aryl-7,7-dimethyl-4H-benzo-[b]- pyran-3-ethylcarboxylates under microwave irradiation

A series of 2-amino-5,6,7,8-tetrahydro-5-oxo-4-aryl-7,7-dimethyl-4H-benzo-[b] -pyran-3-ethylcarboxylates were synthesized by reaction of β-cyano-β-carbothoxy styrene and 5,5-dimethyl-1,3-cyclo-hexanedione under microwave irradiation without catalyst and s

Synthesis and characterization of guanine-functionalized mesoporous silica [SBA-16-G]: a metal-free and recyclable heterogeneous solid base catalyst for synthesis of pyran-annulated heterocyclic compounds

Abstract: The synthesis of a new solid base catalyst, i.e., guanine-functionalized mesoporous silica [SBA-16-G], is described. The synthesized catalyst has been fully characterized by FTIR, solid state 13C NMR, TGA, XRD, BET, FESEM, EDAX, CHNS elemental analysis, CO2-TPD, and TEM techniques. The surface area and the basicity of the synthesised [SBA-16-G] were found to be 524?m2/g and 3.230?mmol/g, respectively, based on BET and CO2-TPD analysis. The catalytic activity of the synthesized catalyst has been explored in the synthesis of a series of biologically and pharmaceutically active pyran-annulated heterocyclic compounds from a one-pot three-component reaction of an aromatic aldehyde, malononitrile/ethyl cyanoacetate, and a C–H activated acidic compound, in the presence of a catalytic amount (10?wt%) of [SBA-16-G]. The catalyst is metal-free, easy to synthesize and to isolate from the reaction mixture, and recycled up to four times without significant loss of catalytic activity. Graphical abstract: [Figure not available: see fulltext.].

Uncatalyzed reactions in aqueous media: Three-component, one-pot, clean synthesis of tetrahydrobenzo[b]pyran derivatives

The synthesis of various tetrahydrobenzo[b]pyran derivatives has been carried out by means of an uncatalyzed, three-component, one-pot clean condensation of aromatic aldehydes, reactive methylene compounds, and dimidone in aqueous medium. Simple workup, and mild and neutral conditions that give quantitative yields of products in pure form, are the attractive features of this method. CSIRO 2007.

1,4-Diazabicyclo[2.2.2]octane as an efficient catalyst for a clean, one-pot synthesis of tetrahydrobenzo[b]pyran derivatives via multicomponent reaction in aqueous media

1,4-Diazabicyclo[2.2.2]octane (DABCO) has been used as a mild and efficient catalyst for the synthesis of various tetrahydrobenzo[b]pyran derivatives via a one-pot, three component condensation of aromatic aldehydes, dimedone, and active methylene compounds. This method provides several advantages: a simple workup procedure, environmental friendliness, neutral conditions, and good yields. In addition, water or 50% aqueous ethanol was chosen as a green solvent. Taylor & Francis Group, LLC.

A convenient synthesis of 5-oxo-5,6,7,8-tetrahydro-4H-benzo-[b]-pyran derivatives catalyzed by KF-alumina

A series of 5-oxo-5,6,7,8-tetrahydro-4H-benzo-[b]-pyran derivatives were prepared by the reaction of arylmethylidenemalononitriles or 2-cyano-3-aryl-1-acrylate with 5,5-dimethyl-1,3-cyclohexanedione (dimedone) in DMF at room temperature catalyzed by KF-al