108082-72-0Relevant articles and documents
Total synthesis of 4-epi-atpenin A5 as a potent nematode complex II inhibitor
Lee, Daiki,Kondo, Hiroki,Kuwayama, Yui,Takahashi, Kento,Arima, Shiho,Omura, Satoshi,Ohtawa, Masaki,Nagamitsu, Tohru
, p. 3178 - 3185 (2019)
It is clear that atpenins and their analogs are useful chemical tools for elucidation of complex II functionality and that they could act as lead compounds for the development of novel helminth complex II-specific inhibitors. Recently, we discovered 4-epi
METHOD FOR PRODUCING OXYPYRIDINE COMPOUND AND ATPENIN ANALOG
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Paragraph 0108-0111, (2019/08/06)
PROBLEM TO BE SOLVED: To provide a method for producing an oxypyridine compound at low cost and/or with high efficiency. SOLUTION: A method for producing a compound represented by formula (I) [R1, R2, R3 and R4
TDO2 INHIBITORS
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Paragraph 2208, (2017/07/14)
Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.
2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS
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Page/Page column 120, (2008/12/04)
Provided are compounds that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS
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Page/Page column 63-64; 66, (2010/11/30)
Compounds of the formula (I), wherein: -X=Y- is selected from -CR2=CR3- and -CR2=N-; R1 is selected from H, halo, NRR', NHC(=O)R, NHC(=O)NRR', NH2SO2R, and C(=O)NRR'; R2 and R3 (where present) are independently selected from H, optionally substituted C1-7 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, halo, amino, amido, hydroxy, ether, thio, thioether, acylamido, ureido and sulfonamino; R4 is an optionally substituted C5-20 aryl or C5-20 heteroaryl group; and R5 is selected from R5’, halo, NHR5’, C(=O)NHR5’, OR5’, SR5’, NHC(=O)R5’, NHC(=O)NHR5’, NHS(=O)R5’, wherein R5’ is H or C1-3 alkyl (optionally substituted by halo, NH2, OH, SH) are disclosed for use in therapy and for treating diseases ameliorated by inhibiting p38 MAP kinase.
8-Piperazinyl-2,3-dihydro-1,4-dioxinopyridine Derivatives: Synthesis and Interaction with 5-HT Serotonin Binding Sites
Joseph, Benoit,Benarab, Abdelhakim,Guillaumet, Gerald
, p. 1355 - 1360 (2007/10/02)
The synthesis of 8-piperazinyl-2,3-dihydro-1,4-dioxinopyridine derivatives (6a-c) are described.Their affinity and selectivity for 5-HT serotoninergic sites were evaluated.
Zwitterionic Analogues of Cimetidine as H2 Receptor Antagonists
Young, Rodney C.,Ganellin, C. Robin,Graham, Michael J.,Mitchell, Robert C.,Roantree, Michael L.,Tashma, Zev
, p. 1150 - 1156 (2007/10/02)
A series of analogues of the H2 receptor histamine antagonist cimetidine have been synthesized in which the dipolar cyanoguanidine group has been replaced by a number of zwitterionic moieties.Although none of the compounds is more effective tha
2-[2-Thiazolyl or 2-guanidino-4-thiazolyl methylthioethyl(or butyl)amino]-3-(hydroxy or carboxy)pyridines, compositions containing same and method of use
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, (2008/06/13)
This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal heterocyclic group. The compounds have histamine H2 -antagonist activity. A specific compound of this invention is 2-[2-(2-guanidino-4-thiazolylmethylthio)ethyl]amino pyridine 3-carboxylic acid.