1093065-15-6

Basic information

• Product Name: 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine
• Synonyms: 7-ethoxy-5-[2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine; 1H-Pyrazolo[4,3-d]pyrimidine, 7-ethoxy-5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl] phenyl]-1-methyl-3-propyl-
• CAS NO: 1093065-15-6
• Molecular Formula: C₂₄H₃₄N₆O₄S
• Molecular Weight: 502.63000
• Mol File: 1093065-15-6.mol

Chemical Properties

• CAS DataBase Reference: 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine(1093065-15-6)
• EPA Substance Registry System: 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine(1093065-15-6)

Safety Data

• Hazardous Substances Data: 1093065-15-6(Hazardous Substances Data)

Upstream product

• 960009-35-2 2-hydroxy-5-(4-methylpiperazin-1-ylsulphonyl)benzoic acid 
• 139756-02-8 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 
• 960009-36-3 4-[2-hydroxy-5-(4-methylpiperazine-1-ylsulphonyl)benzamido]-1-methyl-3-n-propyl-1H-pyrazole-5-carboxamide 
• 64-67-5 diethyl sulfate 

Downstream Products

• 139755-83-2 viagra 

Relevant articles and documents

Synthesis of Sildenafil citrate and process related impurities

Synthesis of Sildenafil by the O-alkylation of 5-[2-hydroxy-5-(4- methylpiperazin-1-ylsulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H- pyrazolo-[4,3-d]pyrimidin-7-one 8 proved difficult because concomitant alkylation of the pyrimidine moity also occurred. The selective O-alkylation was carried by DCC assisted decarboxilative etherification of the carbonate 9.

INTERMEDIATES FOR PREPARATION OF AN INHIBITOR OF PHOSPHODIESTERASE TYPE 5

Boronic compounds of formula II and the process for their preparation, wherein Y1 and Y2 are selected from hydroxyl, (C1-C4)alcoxyl and phenoxyl optionally substituted with one or two radicals independently selected from (C1-C4)alkyl and (C1-C4)alcoxyl; or alternatively Y1 and Y2 together with the boron atom can form a cyclic system. Process for the preparation of Sildenafil by reaction of a intermediate of formula II with a intermediate of formula III, wherein X3 is a leaving group and R1 is selected from H and (C1-C4)alkyl.