- mCPBA-mediated dioxygenation of unactivated alkenes for the synthesis of 5-imino-2-tetrahydrofuranyl methanol derivatives
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A mCPBA-mediated, metal-free, intramolecular dioxygenation reaction of unactivated alkenes is reported. In the presence of m-chlorobenzoic peracid, different unsaturated amide substrates could be cyclized via epoxide intermediates, producing the corresponding 5-imino-2-tetrahydrofuranyl methanol products in up to 94% yield at room temperature.
- Deng, Xiaojun,Zhang, Luwen,Liu, Huixia,Bai, Yu,He, Wei
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supporting information
(2020/11/24)
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- 4-substituted or unsubstituted tetrahydropyran-4-carboxylic acid or its ester compound compd.
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A process for producing a 4-(un)substituted tetrahydropyran-4-carboxylic acid compound or an ester compound thereof which are represented by the formula (1): (1) (wherein R represents hydrogen or a hydrocarbon group; R represents hydrogen or an optionally substituted hydrocarbon group; and R represents hydrogen or a hydrocarbon group), characterized by reacting a 4-(un)substituted 4-cyanotetrahydropyran compound represented by the formula (2): (2) (wherein R and R are the same as defined above) with water or an alcohol which are represented by the formula (3): ROH (3) (wherein R is the same as defined above) in the presence of an acid or base.
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- BIPHENYL COMPOUNDS AND USES THEREOF
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The present invention relates to biphenyl compounds and uses thereof in medicine. Specifically, the present invention relates to a compound of Formula (I), or a stereoisomer, a geometric isomer, a tautomer, a mesomer, a racemate, an enantiomer, a diastereoisomer, an N-oxide, a hydrate, a solvate, a metabolite, a hydrolysate, a pharmaceutically acceptable salt or a prodrug thereof. The compound disclosed herein is used as a therapeutic agent particularly a GPR40 agonist for treating diabetes and metabolic disease in a patient.
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Paragraph 00324
(2015/05/19)
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- AMINOPYRIMIDINONES AS INTERLEUKIN RECEPTOR-ASSOCIATED KINASE INHIBITORS
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This invention relates to aminopyrimidinone compounds of Formula (I) that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment or prevention of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.
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Page/Page column 184; 185
(2013/05/22)
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- Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
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This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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- Preparation of tetrahydropyran-4-carboxylic acid and esters thereof
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A process for the preparation of tetrahydropyran-4-carboxylic acid and esters thereof of the general formula I STR1 in which R1 denotes hydrogen, C1 -C6 alkyl, C5 -C8 cycloalkyl, or aryl by the reaction of a dihydro-2(3H)furanone of the general formula II STR2 in which R2 denotes hydrogen, C1 -C6 alkyl, or --CO--R3 and R3 denotes hydrogen or C1 -C6 alkyl, with water or an alcohol of the general formula III in which R1 has the aforementioned meaning, at temperatures ranging from 200° to 350° C. in the presence of a heterogenous acid catalyst, in which use is made of a fixed heterogenous acid catalyst.
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- Twisted Si=N bonds: Matrix isolation of bridgehead silanimines
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We report the IR and UV-vis spectra of three bridgehead silanimines, 1-sila-2-azabicyclo[3.2.2]non-1(2)-ene, 1-sila-2-azabicyclo[3.2.1]oct-1(2)-ene, and 1-sila-2-azabicyclo[2.2.2]oct-1(2)-ene, prepared in matrix isolation by UV irradiation of bridgehead s
- Radziszewski, Juliusz G.,Kaszynski, Piotr,Littmann, Dieter,Balaji,Hess Jr.,Michl, Josef
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p. 8401 - 8408
(2007/10/02)
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