110963-29-6

Basic information

• Product Name: 3-AMINO-1H-INDOLE-2-CARBOHYDRAZIDE
• Synonyms: 3-AMINO-1H-INDOLE-2-CARBOHYDRAZIDE;3-aminoindol-2-carbohydrazide
• CAS NO: 110963-29-6
• Molecular Formula: C₉H₁₀N₄O
• Molecular Weight: 190.2
• Product Categories: Indole
• Mol File: 110963-29-6.mol

Chemical Properties

• Melting Point: 197-199°C
• Appearance: /
• Density: 1.444 g/cm³
• Refractive Index: 1.78
• PKA: 13.71±0.30(Predicted)
• CAS DataBase Reference: 3-AMINO-1H-INDOLE-2-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-1H-INDOLE-2-CARBOHYDRAZIDE(110963-29-6)
• EPA Substance Registry System: 3-AMINO-1H-INDOLE-2-CARBOHYDRAZIDE(110963-29-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 110963-29-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-1H-indole-2-carbohydrazide is used as a key intermediate in the synthesis of pharmaceuticals for its anti-tumor, antibacterial, and anti-inflammatory properties. It contributes to the development of new drugs that can target a wide range of diseases and conditions.
Used in Organic Chemistry:
3-Amino-1H-indole-2-carbohydrazide is used as a reagent in organic chemistry for its ability to react with various compounds, facilitating the synthesis of complex organic molecules.
Used in Dye and Pigment Production:
3-Amino-1H-indole-2-carbohydrazide is used in the production of dyes and pigments due to its chemical properties that allow for the creation of a wide range of colors.
Used in Research and Development:
3-Amino-1H-indole-2-carbohydrazide is used as a research compound for exploring its potential applications in the medical and pharmaceutical industries, as well as for understanding its biological activities and mechanisms of action.

InChI:InChI=1/C9H10N4O/c10-7-5-3-1-2-4-6(5)12-8(7)9(14)13-11/h1-4,12H,10-11H2,(H,13,14)

Upstream product

• 87223-77-6 ethyl 3-amino-1H-indole-2-carboxylate 
• 110963-25-2 ethyl 3-(benzoylamino)-1H-indole-2-carboxylate 

Downstream Products

• 143604-05-1 3-Amino-1H-indole-2-carboxylic acid [1-(4-trifluoromethyl-phenyl)-meth-(E)-ylidene]-hydrazide 
• 143603-99-0 3-Amino-1H-indole-2-carboxylic acid [1-(4-benzyloxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 143604-02-8 3-Amino-1H-indole-2-carboxylic acid [1-(4-phenoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 143603-93-4 3-{[1-(4-Phenoxy-phenyl)-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid [1-(4-phenoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 143604-04-0 3-Amino-indole-2-carboxylic acid (4-methylbenzylidene)-hydrazide 
• 143603-96-7 3-{[1-p-Tolyl-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid [1-p-tolyl-meth-(E)-ylidene]-hydrazide 
• 135086-86-1 2-(4-Chlorobenzylidene)-1-(3-aminoindole)-2-carbohydrazine 
• 143603-91-2 3-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 135086-85-0 2-(4-Nitrobenzylidene)-1-(3-aminoindole)-2-carbohydrazine 
• 143603-87-6 3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 135086-89-4 2-(4-Acetamidobenzylidene)-1-(3-aminoindole)-2-carbohydrazine 
• 143603-94-5 N-[4-({(E)-2-[1-(4-Acetylamino-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-1H-indol-3-ylimino}-methyl)-phenyl]-acetamide 
• 135086-88-3 2-(3,4,5-Trimethoxybenzylidene)-1-(3-aminoindole)-2-carbohydrazine 
• 143603-90-1 3-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid [1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide 

Relevant articles and documents

Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs thereof, represented by the general Formula I: wherein X, Ar1, R2-R6 and R12 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

New indole and triazino[5,4-b]indol-4-one derivatives: Synthesis and studies as inotropics and inhibitors of blood platelet aggregation

New triazino[5,4b]indol-4-one derivatives carrying amino groups in position 3 were synthetized and tested as inotropic agents and inhibitors of platelet aggregation 2h, 2p, 5p, and 6g are the most active as inotropic agents. Compounds were tested as inhib