- 1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors
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Human neutrophil elastase (HNE) is a serine protease that is expressed in polymorphonuclear neutrophils. It has been recognized as an important therapeutic target for treating inflammatory diseases, especially related to the respiratory system, but also f
- Bartolucci, Gianluca,Cantini, Niccolo,Crocetti, Letizia,Giovannoni, Maria Paola,Guerrini, Gabriella,Pallecchi, Marco,Quinn, Mark T.,Schepetkin, Igor A.,Teodori, Elisabetta,Vergelli, Claudia
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supporting information
(2021/10/04)
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- AROMATIC COMPOUND PRODUCTION METHOD
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Provided is a method for producing an aromatic compound, which can produce a particular aromatic compound at high yield and can be industrially utilized. According to the invention, there is provided a method for producing an aromatic compound, including an aromatization reaction which includes reacting an oxime compound represented by Formula (1) with an acylating agent in the presence of a hydroquinone compound and a palladium compound, and thus obtaining an aromatic compound.
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Paragraph 0097-0100
(2018/08/20)
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- Pyrazolo[3,4-h]quinolines promising photosensitizing agents in the treatment of cancer
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A new series of pyrazolo[3,4-h]quinolines, heteroanalogues of angelicin was conveniently prepared with a broad substitution pattern. A large number of derivatives was obtained and the cellular photocytotoxicity was evaluated in vitro against 5 different h
- Spanò, Virginia,Parrino, Barbara,Carbone, Anna,Montalbano, Alessandra,Salvador, Alessia,Brun, Paola,Vedaldi, Daniela,Diana, Patrizia,Cirrincione, Girolamo,Barraja, Paola
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p. 334 - 351
(2015/09/01)
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- TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES
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The present invention provides tricyclic indoles and (4,5-dihydro) indoles of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring A represents a fused pyrazole, pyridine or pyrimidine, ----- means either simple or double carbon
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Page/Page column 58
(2008/12/06)
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- SYNTHESIS OF ANGULAR BENZODIPYRAZOLES AND RELATED SYSTEMS
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A series of benzodipyrazoles was prepared from cyclohexane-1,3-dione.Several related systems with different central rings were also prepared.In addition, benzodipyrazoles were synthesized from 1,4-cyclohexanedione monoethylene
- Peet, Norton P.,LeTourneau, Michael E.
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- Dipyrazoles and their use as bronchodilators
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A group of variously methyl-substituted[1,2-c:3,4-c']dipyrazoles, cyclohepta[1,2-c:3,4-c']dipyrazoles, and cyclopenta[1,2-c:3,4-c']dipyrazoles useful as bronchodilators are described herein. The compounds are prepared by reacting a 1,3-diketone with hydra
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