912259-10-0

Basic information

• Product Name: 6,7-dihydro-1H-indazol-4(5H)-one
• Synonyms: 6,7-dihydro-1H-indazol-4(5H)-one;2,5,6,7-Tetrahydro-4H-indazol-4-one;6,7-dihydro-2H-indazol-4(5H)-one
• CAS NO: 912259-10-0
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15122
• Mol File: 912259-10-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 229-231℃
• Appearance: /
• Density: 1.305±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 6,7-dihydro-1H-indazol-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dihydro-1H-indazol-4(5H)-one(912259-10-0)
• EPA Substance Registry System: 6,7-dihydro-1H-indazol-4(5H)-one(912259-10-0)

Safety Data

• Hazardous Substances Data: 912259-10-0(Hazardous Substances Data)

Usage

General Description

6,7-dihydro-1H-indazol-4(5H)-one is a chemical compound with the molecular formula C8H8N2O. It is a bicyclic compound that contains an indazole ring and a ketone functional group. The compound has potential pharmaceutical applications, as it exhibits antitumor and antiproliferative activities. It also shows potential as an anti-inflammatory and analgesic agent. 6,7-dihydro-1H-indazol-4(5H)-one has been studied for its ability to inhibit the growth of cancer cells and for its potential use in the treatment of cancer. Its unique structure and therapeutic potential make it an interesting compound for further research and development.

Upstream product

• 64-18-6 formic acid 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 
• 504-02-9 1,3-cylohexanedione 
• 85302-07-4 2-(dimethylaminomethylene)cyclohexane-1,3-dione 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 586353-04-0 2-triphenylmethyl-6,7-dihydro-2H-indazole-4(5H)-one 
• 955406-75-4 tert-butyl 4-oxo-4,5,6,7-tetrahydro-1H-indazole-1-carboxylate 
• 955406-76-5 4-oxo-4,5,6,7-tetrahydro-indazole-2-carboxylic acid tert-butyl ester 
• 1314139-86-0 5-bromo-2-trityl-2,5,6,7-tetrahydro-indazol-4-one 
• 1314139-87-1 5-bromo-2-(4-methoxy-benzyl)-2,5,6,7-tetrahydro-indazol-4-one 
• 1314140-30-1 2-(4-methoxy-benzyl)-2,5,6,7-tetrahydro-indazol-4-one 
• 1027617-67-9 2-methyl-4,5,6,7-tetrahydro-2H-indazol-4-one 
• 1027617-69-1 C₁₄H₁₄N₂O 
• 115310-16-2 1,5,6,7-tetrahydro-1-(phenylmethyl)indazol-4-one 
• 1203661-45-3 1-(3-trifluoromethylphenyl)-1,5,6,7-tetrahydroindazol-4-one 

Relevant articles and documents

Design, synthesis and biological evaluation of selective histone deacetylase 6 (HDAC6) inhibitors bearing benzoindazole or pyrazoloindazole scaffold as surface recognition motif

A series of compounds were designed and synthesized based on the compound 11i bearing phenylpyrazole scaffold with histone deacetylase 6 (HDAC6) inhibitory activity. Most of the compounds showed considerable inhibitory activity against HDAC6 and compound

Mercaptan compound having HDAC6 (histone deacetylase 6) inhibitory activity and application thereof

The invention belongs to the technical field of medicines and relates to a mercaptan compound having an anti-tumor activity, in particular to a mercaptan compound containing a 6(7)-substituted-N-(6-decylhexyl)-pyrazolo[3,4-e] indazole-3-formamide fragment

AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.